No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy

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Standard

No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy. / Fjell, Anders M; Sørensen, Øystein; Wang, Yunpeng; Amlien, Inge K; Baaré, William F C; Bartrés-Faz, David; Bertram, Lars; Boraxbekk, Carl-Johan; Brandmaier, Andreas M; Demuth, Ilja; Drevon, Christian A; Ebmeier, Klaus P; Ghisletta, Paolo; Kievit, Rogier; Kühn, Simone; Madsen, Kathrine Skak; Mowinckel, Athanasia M; Nyberg, Lars; Sexton, Claire E; Solé-Padullés, Cristina; Vidal-Piñeiro, Didac; Wagner, Gerd; Watne, Leiv Otto; Walhovd, Kristine B.

In: Nature Human Behaviour, Vol. 7, No. 11, 11.2023, p. 2008-2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fjell, AM, Sørensen, Ø, Wang, Y, Amlien, IK, Baaré, WFC, Bartrés-Faz, D, Bertram, L, Boraxbekk, C-J, Brandmaier, AM, Demuth, I, Drevon, CA, Ebmeier, KP, Ghisletta, P, Kievit, R, Kühn, S, Madsen, KS, Mowinckel, AM, Nyberg, L, Sexton, CE, Solé-Padullés, C, Vidal-Piñeiro, D, Wagner, G, Watne, LO & Walhovd, KB 2023, 'No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy', Nature Human Behaviour, vol. 7, no. 11, pp. 2008-2022. https://doi.org/10.1038/s41562-023-01707-5

APA

Fjell, A. M., Sørensen, Ø., Wang, Y., Amlien, I. K., Baaré, W. F. C., Bartrés-Faz, D., Bertram, L., Boraxbekk, C-J., Brandmaier, A. M., Demuth, I., Drevon, C. A., Ebmeier, K. P., Ghisletta, P., Kievit, R., Kühn, S., Madsen, K. S., Mowinckel, A. M., Nyberg, L., Sexton, C. E., ... Walhovd, K. B. (2023). No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy. Nature Human Behaviour, 7(11), 2008-2022. https://doi.org/10.1038/s41562-023-01707-5

Vancouver

Fjell AM, Sørensen Ø, Wang Y, Amlien IK, Baaré WFC, Bartrés-Faz D et al. No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy. Nature Human Behaviour. 2023 Nov;7(11):2008-2022. https://doi.org/10.1038/s41562-023-01707-5

Author

Fjell, Anders M ; Sørensen, Øystein ; Wang, Yunpeng ; Amlien, Inge K ; Baaré, William F C ; Bartrés-Faz, David ; Bertram, Lars ; Boraxbekk, Carl-Johan ; Brandmaier, Andreas M ; Demuth, Ilja ; Drevon, Christian A ; Ebmeier, Klaus P ; Ghisletta, Paolo ; Kievit, Rogier ; Kühn, Simone ; Madsen, Kathrine Skak ; Mowinckel, Athanasia M ; Nyberg, Lars ; Sexton, Claire E ; Solé-Padullés, Cristina ; Vidal-Piñeiro, Didac ; Wagner, Gerd ; Watne, Leiv Otto ; Walhovd, Kristine B. / No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy. In: Nature Human Behaviour. 2023 ; Vol. 7, No. 11. pp. 2008-2022.

Bibtex

@article{7069f508ce944ecdb6f950fa79d626fa,

title = "No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy",

abstract = "Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for an association between sleep duration and brain atrophy. In contrast, cross-sectional analyses (51,295 observations) showed inverse U-shaped relationships, where a duration of 6.5 (95% confidence interval, (5.7, 7.3)) hours was associated with the thickest cortex and largest volumes relative to intracranial volume. This fits converging evidence from research on mortality, health and cognition that points to roughly seven hours being associated with good health. Genome-wide association analyses suggested that genes associated with longer sleep for below-average sleepers were linked to shorter sleep for above-average sleepers. Mendelian randomization did not yield evidence for causal impacts of sleep on brain structure. The combined results challenge the notion that habitual short sleep causes brain atrophy, suggesting that normal brains promote adequate sleep duration-which is shorter than current recommendations.",

keywords = "Adult, Humans, Sleep Duration, Cross-Sectional Studies, Genome-Wide Association Study, Brain/diagnostic imaging, Sleep Wake Disorders/diagnostic imaging, Atrophy",

author = "Fjell, {Anders M} and {\O}ystein S{\o}rensen and Yunpeng Wang and Amlien, {Inge K} and Baar{\'e}, {William F C} and David Bartr{\'e}s-Faz and Lars Bertram and Carl-Johan Boraxbekk and Brandmaier, {Andreas M} and Ilja Demuth and Drevon, {Christian A} and Ebmeier, {Klaus P} and Paolo Ghisletta and Rogier Kievit and Simone K{\"u}hn and Madsen, {Kathrine Skak} and Mowinckel, {Athanasia M} and Lars Nyberg and Sexton, {Claire E} and Cristina Sol{\'e}-Padull{\'e}s and Didac Vidal-Pi{\~n}eiro and Gerd Wagner and Watne, {Leiv Otto} and Walhovd, {Kristine B}",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = nov,

doi = "10.1038/s41562-023-01707-5",

language = "English",

volume = "7",

pages = "2008--2022",

journal = "Nature Human Behaviour",

issn = "2397-3374",

publisher = "Nature Publishing Group",

number = "11",

}

RIS

TY - JOUR

T1 - No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy

AU - Fjell, Anders M

AU - Sørensen, Øystein

AU - Wang, Yunpeng

AU - Amlien, Inge K

AU - Baaré, William F C

AU - Bartrés-Faz, David

AU - Bertram, Lars

AU - Boraxbekk, Carl-Johan

AU - Brandmaier, Andreas M

AU - Demuth, Ilja

AU - Drevon, Christian A

AU - Ebmeier, Klaus P

AU - Ghisletta, Paolo

AU - Kievit, Rogier

AU - Kühn, Simone

AU - Madsen, Kathrine Skak

AU - Mowinckel, Athanasia M

AU - Nyberg, Lars

AU - Sexton, Claire E

AU - Solé-Padullés, Cristina

AU - Vidal-Piñeiro, Didac

AU - Wagner, Gerd

AU - Watne, Leiv Otto

AU - Walhovd, Kristine B

PY - 2023/11

Y1 - 2023/11

N2 - Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for an association between sleep duration and brain atrophy. In contrast, cross-sectional analyses (51,295 observations) showed inverse U-shaped relationships, where a duration of 6.5 (95% confidence interval, (5.7, 7.3)) hours was associated with the thickest cortex and largest volumes relative to intracranial volume. This fits converging evidence from research on mortality, health and cognition that points to roughly seven hours being associated with good health. Genome-wide association analyses suggested that genes associated with longer sleep for below-average sleepers were linked to shorter sleep for above-average sleepers. Mendelian randomization did not yield evidence for causal impacts of sleep on brain structure. The combined results challenge the notion that habitual short sleep causes brain atrophy, suggesting that normal brains promote adequate sleep duration-which is shorter than current recommendations.

AB - Short sleep is held to cause poorer brain health, but is short sleep associated with higher rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy adults, we found no evidence for an association between sleep duration and brain atrophy. In contrast, cross-sectional analyses (51,295 observations) showed inverse U-shaped relationships, where a duration of 6.5 (95% confidence interval, (5.7, 7.3)) hours was associated with the thickest cortex and largest volumes relative to intracranial volume. This fits converging evidence from research on mortality, health and cognition that points to roughly seven hours being associated with good health. Genome-wide association analyses suggested that genes associated with longer sleep for below-average sleepers were linked to shorter sleep for above-average sleepers. Mendelian randomization did not yield evidence for causal impacts of sleep on brain structure. The combined results challenge the notion that habitual short sleep causes brain atrophy, suggesting that normal brains promote adequate sleep duration-which is shorter than current recommendations.

KW - Adult

KW - Humans

KW - Sleep Duration

KW - Cross-Sectional Studies

KW - Genome-Wide Association Study

KW - Brain/diagnostic imaging

KW - Sleep Wake Disorders/diagnostic imaging

KW - Atrophy

U2 - 10.1038/s41562-023-01707-5

DO - 10.1038/s41562-023-01707-5

M3 - Journal article

C2 - 37798367

VL - 7

SP - 2008

EP - 2022

JO - Nature Human Behaviour

JF - Nature Human Behaviour

SN - 2397-3374

IS - 11

ER -

ID: 375630303