No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia. / Nyegaard, Mette; Demontis, Ditte; Thestrup, Britta Boserup; Hedemand, Anne; Sørensen, Karina Meden; Hansen, Thomas; Werge, Thomas; Hougaard, David Michael; Yolken, Robert H; Mortensen, Preben Bo; Mors, Ole; Børglum, Anders.

In: Psychiatric Genetics, Vol. 22, No. 3, 06.2012, p. 146-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nyegaard, M, Demontis, D, Thestrup, BB, Hedemand, A, Sørensen, KM, Hansen, T, Werge, T, Hougaard, DM, Yolken, RH, Mortensen, PB, Mors, O & Børglum, A 2012, 'No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia', Psychiatric Genetics, vol. 22, no. 3, pp. 146-8. https://doi.org/10.1097/YPG.0b013e328353953c

APA

Nyegaard, M., Demontis, D., Thestrup, B. B., Hedemand, A., Sørensen, K. M., Hansen, T., Werge, T., Hougaard, D. M., Yolken, R. H., Mortensen, P. B., Mors, O., & Børglum, A. (2012). No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia. Psychiatric Genetics, 22(3), 146-8. https://doi.org/10.1097/YPG.0b013e328353953c

Vancouver

Nyegaard M, Demontis D, Thestrup BB, Hedemand A, Sørensen KM, Hansen T et al. No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia. Psychiatric Genetics. 2012 Jun;22(3):146-8. https://doi.org/10.1097/YPG.0b013e328353953c

Author

Nyegaard, Mette ; Demontis, Ditte ; Thestrup, Britta Boserup ; Hedemand, Anne ; Sørensen, Karina Meden ; Hansen, Thomas ; Werge, Thomas ; Hougaard, David Michael ; Yolken, Robert H ; Mortensen, Preben Bo ; Mors, Ole ; Børglum, Anders. / No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia. In: Psychiatric Genetics. 2012 ; Vol. 22, No. 3. pp. 146-8.

Bibtex

@article{b303f65ade9646828b425a446b1106bf,
title = "No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia",
abstract = "The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.",
author = "Mette Nyegaard and Ditte Demontis and Thestrup, {Britta Boserup} and Anne Hedemand and S{\o}rensen, {Karina Meden} and Thomas Hansen and Thomas Werge and Hougaard, {David Michael} and Yolken, {Robert H} and Mortensen, {Preben Bo} and Ole Mors and Anders B{\o}rglum",
year = "2012",
month = jun,
doi = "10.1097/YPG.0b013e328353953c",
language = "English",
volume = "22",
pages = "146--8",
journal = "Psychiatric Genetics",
issn = "0955-8829",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia

AU - Nyegaard, Mette

AU - Demontis, Ditte

AU - Thestrup, Britta Boserup

AU - Hedemand, Anne

AU - Sørensen, Karina Meden

AU - Hansen, Thomas

AU - Werge, Thomas

AU - Hougaard, David Michael

AU - Yolken, Robert H

AU - Mortensen, Preben Bo

AU - Mors, Ole

AU - Børglum, Anders

PY - 2012/6

Y1 - 2012/6

N2 - The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.

AB - The human endogenous retrovirus HERV-K18 is located within intron 1 of CD48 on chromosome 1q and is still active in the human genome. Genetic variation in HERV-K18 single-nucleotide polymorphisms (SNPs) has previously been associated with an increased risk of schizophrenia (SZ) and with type 2 diabetes (T2D) among individuals with SZ. Here, we present a replication study of association of two SNPs in HERV-K18 and 19 tagSNPs in CD48 with (a) SZ and (b) T2D in patients with SZ in two Danish samples (total number of cases=750 and controls=1214). No association was found with SZ or with T2D among individuals with SZ for any of the investigated SNPs. However, one HERV-K18 SNP showed a tendency toward an association with T2D in younger SZ patients, in agreement with previous findings, but due to a very low sample size, this result needs to be further investigated.

U2 - 10.1097/YPG.0b013e328353953c

DO - 10.1097/YPG.0b013e328353953c

M3 - Journal article

C2 - 22495247

VL - 22

SP - 146

EP - 148

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 3

ER -

ID: 48611319