Next-generation sequencing for antenatal prediction of KEL1 blood group status

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

Standard

Next-generation sequencing for antenatal prediction of KEL1 blood group status. / Rieneck, Klaus; Clausen, Frederik Banch; Dziegiel, Morten Hanefeld.

Molecular Typing of Blood Cell Antigens. Vol. 1310 Humana Press, 2015. p. 115-121 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

Harvard

Rieneck, K, Clausen, FB & Dziegiel, MH 2015, Next-generation sequencing for antenatal prediction of KEL1 blood group status. in Molecular Typing of Blood Cell Antigens. vol. 1310, Humana Press, Methods in Molecular Biology, pp. 115-121. https://doi.org/10.1007/978-1-4939-2690-9_10

APA

Rieneck, K., Clausen, F. B., & Dziegiel, M. H. (2015). Next-generation sequencing for antenatal prediction of KEL1 blood group status. In Molecular Typing of Blood Cell Antigens (Vol. 1310, pp. 115-121). Humana Press. Methods in Molecular Biology https://doi.org/10.1007/978-1-4939-2690-9_10

Vancouver

Rieneck K, Clausen FB, Dziegiel MH. Next-generation sequencing for antenatal prediction of KEL1 blood group status. In Molecular Typing of Blood Cell Antigens. Vol. 1310. Humana Press. 2015. p. 115-121. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-2690-9_10

Author

Rieneck, Klaus ; Clausen, Frederik Banch ; Dziegiel, Morten Hanefeld. / Next-generation sequencing for antenatal prediction of KEL1 blood group status. Molecular Typing of Blood Cell Antigens. Vol. 1310 Humana Press, 2015. pp. 115-121 (Methods in Molecular Biology).

Bibtex

@inbook{a1ec3b79f91d43638e936a9ea7c473a2,
title = "Next-generation sequencing for antenatal prediction of KEL1 blood group status",
abstract = "The KEL1 antigen can give rise to immunization of KEL2 mothers. Maternal antibodies can be transferred to the fetus and destroy fetal red blood cells and their stem cell precursors and give rise to serious fetal disease. It is important to be able to predict the fetal KEL status in order to intervene in those pregnancies where the fetus is at risk, and to ascertain when the fetus is not at risk. Technically it can be demanding to predict KEL1 status from a maternal blood sample. The KEL1 allele is based on a single SNP present in about 1–10 % of cell-free maternal DNA after gestation week 10. Here we describe our protocol for antenatal prediction of fetal KEL1 status by NGS analysis of maternal DNA on a MiSeq instrument.",
keywords = "Antenatal, DNA, KEL, NGS, Phenotype prediction",
author = "Klaus Rieneck and Clausen, {Frederik Banch} and Dziegiel, {Morten Hanefeld}",
year = "2015",
doi = "10.1007/978-1-4939-2690-9_10",
language = "English",
volume = "1310",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "115--121",
booktitle = "Molecular Typing of Blood Cell Antigens",
address = "United States",

}

RIS

TY - CHAP

T1 - Next-generation sequencing for antenatal prediction of KEL1 blood group status

AU - Rieneck, Klaus

AU - Clausen, Frederik Banch

AU - Dziegiel, Morten Hanefeld

PY - 2015

Y1 - 2015

N2 - The KEL1 antigen can give rise to immunization of KEL2 mothers. Maternal antibodies can be transferred to the fetus and destroy fetal red blood cells and their stem cell precursors and give rise to serious fetal disease. It is important to be able to predict the fetal KEL status in order to intervene in those pregnancies where the fetus is at risk, and to ascertain when the fetus is not at risk. Technically it can be demanding to predict KEL1 status from a maternal blood sample. The KEL1 allele is based on a single SNP present in about 1–10 % of cell-free maternal DNA after gestation week 10. Here we describe our protocol for antenatal prediction of fetal KEL1 status by NGS analysis of maternal DNA on a MiSeq instrument.

AB - The KEL1 antigen can give rise to immunization of KEL2 mothers. Maternal antibodies can be transferred to the fetus and destroy fetal red blood cells and their stem cell precursors and give rise to serious fetal disease. It is important to be able to predict the fetal KEL status in order to intervene in those pregnancies where the fetus is at risk, and to ascertain when the fetus is not at risk. Technically it can be demanding to predict KEL1 status from a maternal blood sample. The KEL1 allele is based on a single SNP present in about 1–10 % of cell-free maternal DNA after gestation week 10. Here we describe our protocol for antenatal prediction of fetal KEL1 status by NGS analysis of maternal DNA on a MiSeq instrument.

KW - Antenatal

KW - DNA

KW - KEL

KW - NGS

KW - Phenotype prediction

U2 - 10.1007/978-1-4939-2690-9_10

DO - 10.1007/978-1-4939-2690-9_10

M3 - Book chapter

C2 - 26024630

AN - SCOPUS:84930960112

VL - 1310

T3 - Methods in Molecular Biology

SP - 115

EP - 121

BT - Molecular Typing of Blood Cell Antigens

PB - Humana Press

ER -

ID: 228247351