Nedd8 processing enzymes in Schizosaccharomyces pombe
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Conjugation of the ubiquitin-like modifier Nedd8 to cullins is critical for the function of SCF-type ubiquitin ligases and thus facilitates ubiquitin conjugation and ultimately degradation of SCF substrates, including several cell cycle regulators. Like ubiquitin, Nedd8 is produced as a precursor that must first be processed before it becomes active. In Saccharomyces cerevisiae this is carried out exclusively by the enzyme Yuh1.
Original language | English |
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Journal | B M C Biochemistry |
Volume | 14 |
Issue number | 8 |
Pages (from-to) | 1-6 |
Number of pages | 6 |
ISSN | 1471-2091 |
DOIs | |
Publication status | Published - 2013 |
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ID: 47230163