NANOG reporter cell lines generated by gene targeting in human embryonic stem cells
Research output: Contribution to journal › Journal article › Research › peer-review
Pluripotency and self-renewal of human embryonic stem cells (hESCs) is mediated by a complex interplay between extra- and intracellular signaling pathways, which regulate the expression of pluripotency-specific transcription factors. The homeodomain transcription factor NANOG plays a central role in maintaining hESC pluripotency, but the precise role and regulation of NANOG are not well defined.
| Original language | English |
|---|---|
| Journal | P L o S One |
| Volume | 5 |
| Issue number | 9 |
| ISSN | 1932-6203 |
| DOIs | |
| Publication status | Published - 2010 |
- Cell Line, Embryonic Stem Cells, Gene Expression Regulation, Gene Targeting, Genes, Reporter, Homeodomain Proteins, Humans
Research areas
ID: 46463268