Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases

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Myeloperoxidase : Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases. / Davies, Michael J.

In: Pharmacology and Therapeutics, Vol. 218, 107685, 2021.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Davies, MJ 2021, 'Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases', Pharmacology and Therapeutics, vol. 218, 107685. https://doi.org/10.1016/j.pharmthera.2020.107685

APA

Davies, M. J. (2021). Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases. Pharmacology and Therapeutics, 218, [107685]. https://doi.org/10.1016/j.pharmthera.2020.107685

Vancouver

Davies MJ. Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases. Pharmacology and Therapeutics. 2021;218. 107685. https://doi.org/10.1016/j.pharmthera.2020.107685

Author

Davies, Michael J. / Myeloperoxidase : Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases. In: Pharmacology and Therapeutics. 2021 ; Vol. 218.

Bibtex

@article{e65a4895a42142cfaecc41d8a3c7f151,
title = "Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases",
abstract = "Heme peroxidases are a major source of reactive oxidants at sites of inflammation in biological systems. The formation of some of these oxidants (e.g. hypochlorous acid, HOCl) is important in the innate immune response of activated neutrophils and leukocytes to invading pathogens (e.g. bacteria, yeasts, fungi parasites), and responsible for the anti-microbial activity present in excreted fluids (e.g. hypothiocyanous acid, HOSCN, generated by lactoperoxidase). Other oxidants formed by heme peroxidase family members are important in tissue development (e.g. hypobromous acid, HOBr, formation by peroxidasin) and in the synthesis of thyroid hormones (hypoiodous acid, HOI, synthesized by thyroid peroxidase). However, inadvertent, misplaced or poorly-controlled production of these species can result in host tissue damage, and this underlies the strong association between high levels of some of these enzymes and multiple inflammatory pathologies. As a consequence, there is widespread interest in understanding the kinetics and mechanisms of biomolecule modification by these species, which differ dramatically in their actions, the nature of the products formed (as some of these are specific biomarkers of enzyme activity), and the biological consequences of these reactions in a wide range of diseases associated with acute or chronic inflammation. Increased knowledge of these processes, has allowed the development of a number of alternative and complementary strategies that allow modulation of oxidant formation and subsequent damage. This review discusses developments in these fields and the prospects for tailored inhibition of specific members of this enzyme family.",
keywords = "Enzyme inhibition, Hypochlorous acid, Inflammation, Myeloperoxidase, Oxidation, Protein modification",
author = "Davies, {Michael J.}",
year = "2021",
doi = "10.1016/j.pharmthera.2020.107685",
language = "English",
volume = "218",
journal = "Pharmacology & Therapeutics",
issn = "0163-7258",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Myeloperoxidase

T2 - Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases

AU - Davies, Michael J.

PY - 2021

Y1 - 2021

N2 - Heme peroxidases are a major source of reactive oxidants at sites of inflammation in biological systems. The formation of some of these oxidants (e.g. hypochlorous acid, HOCl) is important in the innate immune response of activated neutrophils and leukocytes to invading pathogens (e.g. bacteria, yeasts, fungi parasites), and responsible for the anti-microbial activity present in excreted fluids (e.g. hypothiocyanous acid, HOSCN, generated by lactoperoxidase). Other oxidants formed by heme peroxidase family members are important in tissue development (e.g. hypobromous acid, HOBr, formation by peroxidasin) and in the synthesis of thyroid hormones (hypoiodous acid, HOI, synthesized by thyroid peroxidase). However, inadvertent, misplaced or poorly-controlled production of these species can result in host tissue damage, and this underlies the strong association between high levels of some of these enzymes and multiple inflammatory pathologies. As a consequence, there is widespread interest in understanding the kinetics and mechanisms of biomolecule modification by these species, which differ dramatically in their actions, the nature of the products formed (as some of these are specific biomarkers of enzyme activity), and the biological consequences of these reactions in a wide range of diseases associated with acute or chronic inflammation. Increased knowledge of these processes, has allowed the development of a number of alternative and complementary strategies that allow modulation of oxidant formation and subsequent damage. This review discusses developments in these fields and the prospects for tailored inhibition of specific members of this enzyme family.

AB - Heme peroxidases are a major source of reactive oxidants at sites of inflammation in biological systems. The formation of some of these oxidants (e.g. hypochlorous acid, HOCl) is important in the innate immune response of activated neutrophils and leukocytes to invading pathogens (e.g. bacteria, yeasts, fungi parasites), and responsible for the anti-microbial activity present in excreted fluids (e.g. hypothiocyanous acid, HOSCN, generated by lactoperoxidase). Other oxidants formed by heme peroxidase family members are important in tissue development (e.g. hypobromous acid, HOBr, formation by peroxidasin) and in the synthesis of thyroid hormones (hypoiodous acid, HOI, synthesized by thyroid peroxidase). However, inadvertent, misplaced or poorly-controlled production of these species can result in host tissue damage, and this underlies the strong association between high levels of some of these enzymes and multiple inflammatory pathologies. As a consequence, there is widespread interest in understanding the kinetics and mechanisms of biomolecule modification by these species, which differ dramatically in their actions, the nature of the products formed (as some of these are specific biomarkers of enzyme activity), and the biological consequences of these reactions in a wide range of diseases associated with acute or chronic inflammation. Increased knowledge of these processes, has allowed the development of a number of alternative and complementary strategies that allow modulation of oxidant formation and subsequent damage. This review discusses developments in these fields and the prospects for tailored inhibition of specific members of this enzyme family.

KW - Enzyme inhibition

KW - Hypochlorous acid

KW - Inflammation

KW - Myeloperoxidase

KW - Oxidation

KW - Protein modification

UR - http://www.scopus.com/inward/record.url?scp=85091688689&partnerID=8YFLogxK

U2 - 10.1016/j.pharmthera.2020.107685

DO - 10.1016/j.pharmthera.2020.107685

M3 - Review

C2 - 32961264

AN - SCOPUS:85091688689

VL - 218

JO - Pharmacology & Therapeutics

JF - Pharmacology & Therapeutics

SN - 0163-7258

M1 - 107685

ER -

ID: 251307593