Mutation of a bHLH transcription factor allowed almond domestication

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mutation of a bHLH transcription factor allowed almond domestication. / Sánchez-Pérez, R.; Pavan, S.; Mazzeo, R.; Moldovan, C.; Aiese Cigliano, R.; Del Cueto, J.; Ricciardi, F.; Lotti, C.; Ricciardi, L.; Dicenta, F.; López-Marqués, R. L.; Lindberg Møller, B.

In: Science, Vol. 364, No. 6445, 14.06.2019, p. 1095-1098.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sánchez-Pérez, R, Pavan, S, Mazzeo, R, Moldovan, C, Aiese Cigliano, R, Del Cueto, J, Ricciardi, F, Lotti, C, Ricciardi, L, Dicenta, F, López-Marqués, RL & Lindberg Møller, B 2019, 'Mutation of a bHLH transcription factor allowed almond domestication', Science, vol. 364, no. 6445, pp. 1095-1098. https://doi.org/10.1126/science.aav8197

APA

Sánchez-Pérez, R., Pavan, S., Mazzeo, R., Moldovan, C., Aiese Cigliano, R., Del Cueto, J., Ricciardi, F., Lotti, C., Ricciardi, L., Dicenta, F., López-Marqués, R. L., & Lindberg Møller, B. (2019). Mutation of a bHLH transcription factor allowed almond domestication. Science, 364(6445), 1095-1098. https://doi.org/10.1126/science.aav8197

Vancouver

Sánchez-Pérez R, Pavan S, Mazzeo R, Moldovan C, Aiese Cigliano R, Del Cueto J et al. Mutation of a bHLH transcription factor allowed almond domestication. Science. 2019 Jun 14;364(6445):1095-1098. https://doi.org/10.1126/science.aav8197

Author

Sánchez-Pérez, R. ; Pavan, S. ; Mazzeo, R. ; Moldovan, C. ; Aiese Cigliano, R. ; Del Cueto, J. ; Ricciardi, F. ; Lotti, C. ; Ricciardi, L. ; Dicenta, F. ; López-Marqués, R. L. ; Lindberg Møller, B. / Mutation of a bHLH transcription factor allowed almond domestication. In: Science. 2019 ; Vol. 364, No. 6445. pp. 1095-1098.

Bibtex

@article{3cb4d84d5cd649aba42adb8d5451d55a,
title = "Mutation of a bHLH transcription factor allowed almond domestication",
abstract = "Wild almond species accumulate the bitter and toxic cyanogenic diglucoside amygdalin. Almond domestication was enabled by the selection of genotypes harboring sweet kernels. We report the completion of the almond reference genome. Map-based cloning using an F1 population segregating for kernel taste led to the identification of a 46-kilobase gene cluster encoding five basic helix-loop-helix transcription factors, bHLH1 to bHLH5. Functional characterization demonstrated that bHLH2 controls transcription of the P450 monooxygenase–encoding genes PdCYP79D16 and PdCYP71AN24, which are involved in the amygdalin biosynthetic pathway. A nonsynonymous point mutation (Leu to Phe) in the dimerization domain of bHLH2 prevents transcription of the two cytochrome P450 genes, resulting in the sweet kernel trait.",
author = "R. S{\'a}nchez-P{\'e}rez and S. Pavan and R. Mazzeo and C. Moldovan and {Aiese Cigliano}, R. and {Del Cueto}, J. and F. Ricciardi and C. Lotti and L. Ricciardi and F. Dicenta and L{\'o}pez-Marqu{\'e}s, {R. L.} and {Lindberg M{\o}ller}, B.",
year = "2019",
month = jun,
day = "14",
doi = "10.1126/science.aav8197",
language = "English",
volume = "364",
pages = "1095--1098",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6445",

}

RIS

TY - JOUR

T1 - Mutation of a bHLH transcription factor allowed almond domestication

AU - Sánchez-Pérez, R.

AU - Pavan, S.

AU - Mazzeo, R.

AU - Moldovan, C.

AU - Aiese Cigliano, R.

AU - Del Cueto, J.

AU - Ricciardi, F.

AU - Lotti, C.

AU - Ricciardi, L.

AU - Dicenta, F.

AU - López-Marqués, R. L.

AU - Lindberg Møller, B.

PY - 2019/6/14

Y1 - 2019/6/14

N2 - Wild almond species accumulate the bitter and toxic cyanogenic diglucoside amygdalin. Almond domestication was enabled by the selection of genotypes harboring sweet kernels. We report the completion of the almond reference genome. Map-based cloning using an F1 population segregating for kernel taste led to the identification of a 46-kilobase gene cluster encoding five basic helix-loop-helix transcription factors, bHLH1 to bHLH5. Functional characterization demonstrated that bHLH2 controls transcription of the P450 monooxygenase–encoding genes PdCYP79D16 and PdCYP71AN24, which are involved in the amygdalin biosynthetic pathway. A nonsynonymous point mutation (Leu to Phe) in the dimerization domain of bHLH2 prevents transcription of the two cytochrome P450 genes, resulting in the sweet kernel trait.

AB - Wild almond species accumulate the bitter and toxic cyanogenic diglucoside amygdalin. Almond domestication was enabled by the selection of genotypes harboring sweet kernels. We report the completion of the almond reference genome. Map-based cloning using an F1 population segregating for kernel taste led to the identification of a 46-kilobase gene cluster encoding five basic helix-loop-helix transcription factors, bHLH1 to bHLH5. Functional characterization demonstrated that bHLH2 controls transcription of the P450 monooxygenase–encoding genes PdCYP79D16 and PdCYP71AN24, which are involved in the amygdalin biosynthetic pathway. A nonsynonymous point mutation (Leu to Phe) in the dimerization domain of bHLH2 prevents transcription of the two cytochrome P450 genes, resulting in the sweet kernel trait.

UR - http://www.scopus.com/inward/record.url?scp=85067619386&partnerID=8YFLogxK

U2 - 10.1126/science.aav8197

DO - 10.1126/science.aav8197

M3 - Journal article

C2 - 31197015

AN - SCOPUS:85067619386

VL - 364

SP - 1095

EP - 1098

JO - Science

JF - Science

SN - 0036-8075

IS - 6445

ER -

ID: 223678520