Muscle and liver glycogen, protein, and triglyceride in the rat: effect of exercise and of the sympatho-adrenal system
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Muscle and liver glycogen, protein, and triglyceride in the rat : effect of exercise and of the sympatho-adrenal system. / Richter, Erik A.; Sonne, Bente; Joensen Mikines, Kari; Ploug, Thorkil; Galbo, Henrik.
In: European Journal of Applied Physiology and Occupational Physiology, Vol. 52, No. 3, 1984, p. 346-350.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Muscle and liver glycogen, protein, and triglyceride in the rat
T2 - effect of exercise and of the sympatho-adrenal system
AU - Richter, Erik A.
AU - Sonne, Bente
AU - Joensen Mikines, Kari
AU - Ploug, Thorkil
AU - Galbo, Henrik
PY - 1984
Y1 - 1984
N2 - We have previously found that during exercise net muscle glycogen breakdown is impaired in adrenodemedullated rats, as compared with controls. The present study was carried out to elucidate whether, in rats with deficiencies of the sympatho-adrenal system, diminished exercise-induced glycogenolysis in skeletal muscle was accompanied by increased breakdown of triglyceride and/or protein. Thus, the effect of exhausting swimming and of running on concentrations of glycogen, protein, and triglyceride in skeletal muscle and liver were studied in rats with and without deficiencies of the sympatho-adrenal system. In control rats, both swimming and running decreased the concentration of glycogen in fast-twitch red and slow-twitch red muscle whereas concentrations of protein and triglyceride did not decrease. In the liver, swimming depleted glycogen stores but protein and triglyceride concentrations did not decrease. In exercising rats, muscle glycogen breakdown was impaired by adrenodemedullation and restored by infusion of epinephrine. However, impaired glycogen breakdown during exercise was not accompanied by a significant net breakdown of protein or triglyceride. Surgical sympathectomy of the muscles did not influence muscle substrate concentrations. The results indicate that when glycogenolysis in exercising muscle is impeded by adrenodemedullation no compensatory increase in breakdown of triglyceride and protein in muscle or liver takes place. Thus, indirect evidence suggests that, in exercising adrenodemedullated rats, fatty acids from adipose tissue were burnt instead of muscle glycogen.
AB - We have previously found that during exercise net muscle glycogen breakdown is impaired in adrenodemedullated rats, as compared with controls. The present study was carried out to elucidate whether, in rats with deficiencies of the sympatho-adrenal system, diminished exercise-induced glycogenolysis in skeletal muscle was accompanied by increased breakdown of triglyceride and/or protein. Thus, the effect of exhausting swimming and of running on concentrations of glycogen, protein, and triglyceride in skeletal muscle and liver were studied in rats with and without deficiencies of the sympatho-adrenal system. In control rats, both swimming and running decreased the concentration of glycogen in fast-twitch red and slow-twitch red muscle whereas concentrations of protein and triglyceride did not decrease. In the liver, swimming depleted glycogen stores but protein and triglyceride concentrations did not decrease. In exercising rats, muscle glycogen breakdown was impaired by adrenodemedullation and restored by infusion of epinephrine. However, impaired glycogen breakdown during exercise was not accompanied by a significant net breakdown of protein or triglyceride. Surgical sympathectomy of the muscles did not influence muscle substrate concentrations. The results indicate that when glycogenolysis in exercising muscle is impeded by adrenodemedullation no compensatory increase in breakdown of triglyceride and protein in muscle or liver takes place. Thus, indirect evidence suggests that, in exercising adrenodemedullated rats, fatty acids from adipose tissue were burnt instead of muscle glycogen.
KW - Adrenal Medulla
KW - Animals
KW - Glycogen
KW - Liver Glycogen
KW - Male
KW - Muscle Proteins
KW - Muscles
KW - Physical Exertion
KW - Rats
KW - Rats, Inbred Strains
KW - Running
KW - Swimming
KW - Sympathetic Nervous System
KW - Triglycerides
U2 - 10.1007/BF01015225
DO - 10.1007/BF01015225
M3 - Journal article
C2 - 6539692
VL - 52
SP - 346
EP - 350
JO - European Journal of Applied Physiology and Occupational Physiology
JF - European Journal of Applied Physiology and Occupational Physiology
SN - 0301-5548
IS - 3
ER -
ID: 123666611