Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations. / Lytzen, Rebekka; Vejlstrup, Niels; Bjerre, Jesper; Petersen, Olav Bjørn; Leenskjold, Stine; Dodd, James Keith; Jørgensen, Finn Stener; Søndergaard, Lars.

In: International Journal of Cardiology, Vol. 290, 2019, p. 93-99.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lytzen, R, Vejlstrup, N, Bjerre, J, Petersen, OB, Leenskjold, S, Dodd, JK, Jørgensen, FS & Søndergaard, L 2019, 'Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations', International Journal of Cardiology, vol. 290, pp. 93-99. https://doi.org/10.1016/j.ijcard.2019.05.017

APA

Lytzen, R., Vejlstrup, N., Bjerre, J., Petersen, O. B., Leenskjold, S., Dodd, J. K., Jørgensen, F. S., & Søndergaard, L. (2019). Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations. International Journal of Cardiology, 290, 93-99. https://doi.org/10.1016/j.ijcard.2019.05.017

Vancouver

Lytzen R, Vejlstrup N, Bjerre J, Petersen OB, Leenskjold S, Dodd JK et al. Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations. International Journal of Cardiology. 2019;290:93-99. https://doi.org/10.1016/j.ijcard.2019.05.017

Author

Lytzen, Rebekka ; Vejlstrup, Niels ; Bjerre, Jesper ; Petersen, Olav Bjørn ; Leenskjold, Stine ; Dodd, James Keith ; Jørgensen, Finn Stener ; Søndergaard, Lars. / Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations. In: International Journal of Cardiology. 2019 ; Vol. 290. pp. 93-99.

Bibtex

@article{a8d75f81836e42adaa36e29d5c21a437,

title = "Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations",

abstract = "BACKGROUND: Major congenital heart diseases (CHD) often demand intervention in the neonatal period. Prenatal diagnosis may improve mortality by eliminating the diagnostic delay; however, there is controversy concerning its true effect. We aimed to evaluate the effect of general prenatal screening on prognosis by comparing a period without general prenatal screening to a period with general prenatal screening.METHODS: We conducted a nationwide retrospective study including live born children and terminated fetuses diagnosed with major CHD. Prenatal screening was recommended only in high risk pregnancies between 1996 and 2004, whereas general prenatal screening was recommended between 2005 and 2013. We assessed the influence of general prenatal screening on all-cause mortality, cardiac death, preoperative and postoperative 30-day mortality and complication rate.RESULTS: 1-year mortality decreased over both periods, but the decrease was greater in the screening period (Odds ratio 0.92 (CI 0.83-1.00), p = 0.047). Prenatal detection of major CHD was associated with cardiac death in the period without general screening (Hazard Ratio 2.40 (CI 1.72-3.33), p < 0.001), whereas there was no significant association once general screening was implemented. Similarly, the association between prenatal diagnosis and pre- and postoperative mortality found in the period without general screening was insignificant after the implementation of general screening.CONCLUSION: Mortality in major CHD decreased throughout the study, especially in the period with general prenatal screening. However, comparing a prenatally diagnosed group with a postnatally diagnosed group is vulnerable to selection bias and proper interpretation is difficult.",

author = "Rebekka Lytzen and Niels Vejlstrup and Jesper Bjerre and Petersen, {Olav Bj{\o}rn} and Stine Leenskjold and Dodd, {James Keith} and J{\o}rgensen, {Finn Stener} and Lars S{\o}ndergaard",

year = "2019",

doi = "10.1016/j.ijcard.2019.05.017",

language = "English",

volume = "290",

pages = "93--99",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Mortality and morbidity of major congenital heart disease related to general prenatal screening for malformations

AU - Lytzen, Rebekka

AU - Vejlstrup, Niels

AU - Bjerre, Jesper

AU - Petersen, Olav Bjørn

AU - Leenskjold, Stine

AU - Dodd, James Keith

AU - Jørgensen, Finn Stener

AU - Søndergaard, Lars

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Major congenital heart diseases (CHD) often demand intervention in the neonatal period. Prenatal diagnosis may improve mortality by eliminating the diagnostic delay; however, there is controversy concerning its true effect. We aimed to evaluate the effect of general prenatal screening on prognosis by comparing a period without general prenatal screening to a period with general prenatal screening.METHODS: We conducted a nationwide retrospective study including live born children and terminated fetuses diagnosed with major CHD. Prenatal screening was recommended only in high risk pregnancies between 1996 and 2004, whereas general prenatal screening was recommended between 2005 and 2013. We assessed the influence of general prenatal screening on all-cause mortality, cardiac death, preoperative and postoperative 30-day mortality and complication rate.RESULTS: 1-year mortality decreased over both periods, but the decrease was greater in the screening period (Odds ratio 0.92 (CI 0.83-1.00), p = 0.047). Prenatal detection of major CHD was associated with cardiac death in the period without general screening (Hazard Ratio 2.40 (CI 1.72-3.33), p < 0.001), whereas there was no significant association once general screening was implemented. Similarly, the association between prenatal diagnosis and pre- and postoperative mortality found in the period without general screening was insignificant after the implementation of general screening.CONCLUSION: Mortality in major CHD decreased throughout the study, especially in the period with general prenatal screening. However, comparing a prenatally diagnosed group with a postnatally diagnosed group is vulnerable to selection bias and proper interpretation is difficult.

AB - BACKGROUND: Major congenital heart diseases (CHD) often demand intervention in the neonatal period. Prenatal diagnosis may improve mortality by eliminating the diagnostic delay; however, there is controversy concerning its true effect. We aimed to evaluate the effect of general prenatal screening on prognosis by comparing a period without general prenatal screening to a period with general prenatal screening.METHODS: We conducted a nationwide retrospective study including live born children and terminated fetuses diagnosed with major CHD. Prenatal screening was recommended only in high risk pregnancies between 1996 and 2004, whereas general prenatal screening was recommended between 2005 and 2013. We assessed the influence of general prenatal screening on all-cause mortality, cardiac death, preoperative and postoperative 30-day mortality and complication rate.RESULTS: 1-year mortality decreased over both periods, but the decrease was greater in the screening period (Odds ratio 0.92 (CI 0.83-1.00), p = 0.047). Prenatal detection of major CHD was associated with cardiac death in the period without general screening (Hazard Ratio 2.40 (CI 1.72-3.33), p < 0.001), whereas there was no significant association once general screening was implemented. Similarly, the association between prenatal diagnosis and pre- and postoperative mortality found in the period without general screening was insignificant after the implementation of general screening.CONCLUSION: Mortality in major CHD decreased throughout the study, especially in the period with general prenatal screening. However, comparing a prenatally diagnosed group with a postnatally diagnosed group is vulnerable to selection bias and proper interpretation is difficult.

U2 - 10.1016/j.ijcard.2019.05.017

DO - 10.1016/j.ijcard.2019.05.017

M3 - Journal article

C2 - 31130278

VL - 290

SP - 93

EP - 99

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -

ID: 226496818