miRandola 2017: a curated knowledge base of non-invasive biomarkers

Research output: Contribution to journalJournal articleResearchpeer-review


  • Francesco Russo
  • Sebastiano Di Bella
  • Federica Vannini
  • Gabriele Berti
  • Flavia Scoyni
  • Helen V Cook
  • Alberto Santos
  • Giovanni Nigita
  • Vincenzo Bonnici
  • Alessandro Laganà
  • Filippo Geraci
  • Alfredo Pulvirenti
  • Rosalba Giugno
  • Federico De Masi
  • Kirstine Belling
  • Jensen, Lars Juhl
  • Brunak, Søren
  • Marco Pellegrini
  • Alfredo Ferro

miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases. Data are manually curated from 314 articles that describe miRNAs, long non-coding RNAs and circular RNAs. Fourteen organisms are now included in the database, and associations of ncRNAs with 25 drugs, 47 sample types and 197 diseases. miRandola also classifies extracellular RNAs based on their extracellular form: Argonaute2 protein, exosome, microvesicle, microparticle, membrane vesicle, high density lipoprotein and circulating. We also implemented a new web interface to improve the user experience.

Original languageEnglish
JournalNucleic Acids Research
Issue numberD1
Pages (from-to)D354-D359
Number of pages6
Publication statusPublished - 1 Jan 2018

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