Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle

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Standard

Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle. / Zheng, Hong; Yde, Christian C; Clausen, Morten R; Kristensen, Mette Bredal; Lorenzen, Janne Kunchel; Astrup, Arne; Bertram, Hanne C.

In: Journal of Agricultural and Food Chemistry, Vol. 63, No. 10, 2015, p. 2830-2839.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zheng, H, Yde, CC, Clausen, MR, Kristensen, MB, Lorenzen, JK, Astrup, A & Bertram, HC 2015, 'Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle', Journal of Agricultural and Food Chemistry, vol. 63, no. 10, pp. 2830-2839. https://doi.org/10.1021/jf505878a

APA

Zheng, H., Yde, C. C., Clausen, M. R., Kristensen, M. B., Lorenzen, J. K., Astrup, A., & Bertram, H. C. (2015). Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle. Journal of Agricultural and Food Chemistry, 63(10), 2830-2839. https://doi.org/10.1021/jf505878a

Vancouver

Zheng H, Yde CC, Clausen MR, Kristensen MB, Lorenzen JK, Astrup A et al. Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle. Journal of Agricultural and Food Chemistry. 2015;63(10):2830-2839. https://doi.org/10.1021/jf505878a

Author

Zheng, Hong ; Yde, Christian C ; Clausen, Morten R ; Kristensen, Mette Bredal ; Lorenzen, Janne Kunchel ; Astrup, Arne ; Bertram, Hanne C. / Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle. In: Journal of Agricultural and Food Chemistry. 2015 ; Vol. 63, No. 10. pp. 2830-2839.

Bibtex

@article{4ce25a8bd2c144b6a20274940afe5871,
title = "Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle",
abstract = "An NMR-based metabolomics approach was used to investigate the differentiation between subjects consuming cheese or milk and to elucidate the potential link to an effect on the blood cholesterol level. Fifteen healthy young men participated in a full cross-over study where they consumed three iso-caloric diets with similar fat contents that were either i) high in milk, ii) high in cheese with equal amounts of dairy calcium, or iii) consisted of a control diet for 14 days. Urine and feces samples were collected and analyzed by NMR-based metabolomics. Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate and lipid. Compared with milk intake, cheese consumption significantly reduced urinary citrate, creatine and creatinine levels and significantly increased the microbial-related metabolites butyrate, hippurate and malonate. Correlation analyses indicated that microbial and lipid metabolism could be involved in the dairy-induced effects on blood cholesterol level.",
author = "Hong Zheng and Yde, {Christian C} and Clausen, {Morten R} and Kristensen, {Mette Bredal} and Lorenzen, {Janne Kunchel} and Arne Astrup and Bertram, {Hanne C}",
note = "CURIS 2015 NEXS 101",
year = "2015",
doi = "10.1021/jf505878a",
language = "English",
volume = "63",
pages = "2830--2839",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "10",

}

RIS

TY - JOUR

T1 - Metabolomics investigation to shed light on cheese as a possible piece in the French paradox puzzle

AU - Zheng, Hong

AU - Yde, Christian C

AU - Clausen, Morten R

AU - Kristensen, Mette Bredal

AU - Lorenzen, Janne Kunchel

AU - Astrup, Arne

AU - Bertram, Hanne C

N1 - CURIS 2015 NEXS 101

PY - 2015

Y1 - 2015

N2 - An NMR-based metabolomics approach was used to investigate the differentiation between subjects consuming cheese or milk and to elucidate the potential link to an effect on the blood cholesterol level. Fifteen healthy young men participated in a full cross-over study where they consumed three iso-caloric diets with similar fat contents that were either i) high in milk, ii) high in cheese with equal amounts of dairy calcium, or iii) consisted of a control diet for 14 days. Urine and feces samples were collected and analyzed by NMR-based metabolomics. Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate and lipid. Compared with milk intake, cheese consumption significantly reduced urinary citrate, creatine and creatinine levels and significantly increased the microbial-related metabolites butyrate, hippurate and malonate. Correlation analyses indicated that microbial and lipid metabolism could be involved in the dairy-induced effects on blood cholesterol level.

AB - An NMR-based metabolomics approach was used to investigate the differentiation between subjects consuming cheese or milk and to elucidate the potential link to an effect on the blood cholesterol level. Fifteen healthy young men participated in a full cross-over study where they consumed three iso-caloric diets with similar fat contents that were either i) high in milk, ii) high in cheese with equal amounts of dairy calcium, or iii) consisted of a control diet for 14 days. Urine and feces samples were collected and analyzed by NMR-based metabolomics. Cheese and milk consumption decreased urinary choline and TMAO levels and increased fecal excretion of acetate, propionate and lipid. Compared with milk intake, cheese consumption significantly reduced urinary citrate, creatine and creatinine levels and significantly increased the microbial-related metabolites butyrate, hippurate and malonate. Correlation analyses indicated that microbial and lipid metabolism could be involved in the dairy-induced effects on blood cholesterol level.

U2 - 10.1021/jf505878a

DO - 10.1021/jf505878a

M3 - Journal article

C2 - 25727903

VL - 63

SP - 2830

EP - 2839

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 10

ER -

ID: 132056970