Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men

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Standard

Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men. / Wang, Ping; Menheere, Paul P C A; Astrup, Arne; Andersen, Malene R; Baak, Marleen A van; Larsen, Thomas Meinert; Jebb, Susan; Kafatos, Anthony; Pfeiffer, Andreas F H; Martinez, J Alfredo; Handjieva-Darlenska, Teodora; Hlavaty, Petr; Viguerie, Nathalie; Langin, Dominique; Saris, Wim H M; Mariman, Edwin C M; on behalf of Diogenes consortium.

In: Obesity, Vol. 21, No. 10, 2013, p. 1997-2006.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wang, P, Menheere, PPCA, Astrup, A, Andersen, MR, Baak, MAV, Larsen, TM, Jebb, S, Kafatos, A, Pfeiffer, AFH, Martinez, JA, Handjieva-Darlenska, T, Hlavaty, P, Viguerie, N, Langin, D, Saris, WHM, Mariman, ECM & on behalf of Diogenes consortium 2013, 'Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men', Obesity, vol. 21, no. 10, pp. 1997-2006. https://doi.org/10.1002/oby.20311

APA

Wang, P., Menheere, P. P. C. A., Astrup, A., Andersen, M. R., Baak, M. A. V., Larsen, T. M., Jebb, S., Kafatos, A., Pfeiffer, A. F. H., Martinez, J. A., Handjieva-Darlenska, T., Hlavaty, P., Viguerie, N., Langin, D., Saris, W. H. M., Mariman, E. C. M., & on behalf of Diogenes consortium (2013). Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men. Obesity, 21(10), 1997-2006. https://doi.org/10.1002/oby.20311

Vancouver

Wang P, Menheere PPCA, Astrup A, Andersen MR, Baak MAV, Larsen TM et al. Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men. Obesity. 2013;21(10):1997-2006. https://doi.org/10.1002/oby.20311

Author

Wang, Ping ; Menheere, Paul P C A ; Astrup, Arne ; Andersen, Malene R ; Baak, Marleen A van ; Larsen, Thomas Meinert ; Jebb, Susan ; Kafatos, Anthony ; Pfeiffer, Andreas F H ; Martinez, J Alfredo ; Handjieva-Darlenska, Teodora ; Hlavaty, Petr ; Viguerie, Nathalie ; Langin, Dominique ; Saris, Wim H M ; Mariman, Edwin C M ; on behalf of Diogenes consortium. / Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men. In: Obesity. 2013 ; Vol. 21, No. 10. pp. 1997-2006.

Bibtex

@article{d3b490aab9c246acba9f19b8a8b3e2cf,
title = "Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men",
abstract = "OBJECTIVE: Weight loss helps reduce the symptoms of the metabolic syndrome (MetS) in the obese, but weight regain after active weight loss is common. We investigated the changes and predictive role of circulating adipokines and sex hormones for weight regain in men during dietary intervention, and also the effect of basal MetS status on weight regain. DESIGN AND METHODS: Twenty-four men who continued to lose weight (WL) and 24 men who regained weight (WR) during the 6-month follow-up period after weight loss were selected from the Diogenes Study. Their circulating concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), luteinizing hormone, prolactin, progesterone, total and free testosterone, and sex hormone-binding globulin (SHBG) were measured at baseline, after 8-week low-calorie diet-induced active weight loss, and after a subsequent 26-week ad libitum weight maintenance diet, and analyzed together with anthropometrical and physiological parameters. RESULTS AND CONCLUSIONS: Overweight and obese men with MetS at baseline had higher risk to regain weight (odds ratio=2.8, P=0.015). High baseline RBP4, and low total testosterone and low SHBG are predictors of weight loss regain (different between WR and WL with P=0.001, 0.038, 0.044, respectively), and may play roles in the link between MetS and weight loss regain.",
author = "Ping Wang and Menheere, {Paul P C A} and Arne Astrup and Andersen, {Malene R} and Baak, {Marleen A van} and Larsen, {Thomas Meinert} and Susan Jebb and Anthony Kafatos and Pfeiffer, {Andreas F H} and Martinez, {J Alfredo} and Teodora Handjieva-Darlenska and Petr Hlavaty and Nathalie Viguerie and Dominique Langin and Saris, {Wim H M} and Mariman, {Edwin C M} and {on behalf of Diogenes consortium}",
note = "CURIS 2013 NEXS 076",
year = "2013",
doi = "10.1002/oby.20311",
language = "English",
volume = "21",
pages = "1997--2006",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men

AU - Wang, Ping

AU - Menheere, Paul P C A

AU - Astrup, Arne

AU - Andersen, Malene R

AU - Baak, Marleen A van

AU - Larsen, Thomas Meinert

AU - Jebb, Susan

AU - Kafatos, Anthony

AU - Pfeiffer, Andreas F H

AU - Martinez, J Alfredo

AU - Handjieva-Darlenska, Teodora

AU - Hlavaty, Petr

AU - Viguerie, Nathalie

AU - Langin, Dominique

AU - Saris, Wim H M

AU - Mariman, Edwin C M

AU - on behalf of Diogenes consortium

N1 - CURIS 2013 NEXS 076

PY - 2013

Y1 - 2013

N2 - OBJECTIVE: Weight loss helps reduce the symptoms of the metabolic syndrome (MetS) in the obese, but weight regain after active weight loss is common. We investigated the changes and predictive role of circulating adipokines and sex hormones for weight regain in men during dietary intervention, and also the effect of basal MetS status on weight regain. DESIGN AND METHODS: Twenty-four men who continued to lose weight (WL) and 24 men who regained weight (WR) during the 6-month follow-up period after weight loss were selected from the Diogenes Study. Their circulating concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), luteinizing hormone, prolactin, progesterone, total and free testosterone, and sex hormone-binding globulin (SHBG) were measured at baseline, after 8-week low-calorie diet-induced active weight loss, and after a subsequent 26-week ad libitum weight maintenance diet, and analyzed together with anthropometrical and physiological parameters. RESULTS AND CONCLUSIONS: Overweight and obese men with MetS at baseline had higher risk to regain weight (odds ratio=2.8, P=0.015). High baseline RBP4, and low total testosterone and low SHBG are predictors of weight loss regain (different between WR and WL with P=0.001, 0.038, 0.044, respectively), and may play roles in the link between MetS and weight loss regain.

AB - OBJECTIVE: Weight loss helps reduce the symptoms of the metabolic syndrome (MetS) in the obese, but weight regain after active weight loss is common. We investigated the changes and predictive role of circulating adipokines and sex hormones for weight regain in men during dietary intervention, and also the effect of basal MetS status on weight regain. DESIGN AND METHODS: Twenty-four men who continued to lose weight (WL) and 24 men who regained weight (WR) during the 6-month follow-up period after weight loss were selected from the Diogenes Study. Their circulating concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), luteinizing hormone, prolactin, progesterone, total and free testosterone, and sex hormone-binding globulin (SHBG) were measured at baseline, after 8-week low-calorie diet-induced active weight loss, and after a subsequent 26-week ad libitum weight maintenance diet, and analyzed together with anthropometrical and physiological parameters. RESULTS AND CONCLUSIONS: Overweight and obese men with MetS at baseline had higher risk to regain weight (odds ratio=2.8, P=0.015). High baseline RBP4, and low total testosterone and low SHBG are predictors of weight loss regain (different between WR and WL with P=0.001, 0.038, 0.044, respectively), and may play roles in the link between MetS and weight loss regain.

U2 - 10.1002/oby.20311

DO - 10.1002/oby.20311

M3 - Journal article

C2 - 23408763

VL - 21

SP - 1997

EP - 2006

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 10

ER -

ID: 44853711