Mesenchymal Stem Cell Therapy for the Treatment of Vocal Fold Scarring: A Systematic Review of Preclinical Studies
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Mesenchymal Stem Cell Therapy for the Treatment of Vocal Fold Scarring : A Systematic Review of Preclinical Studies. / Wingstrand, Vibe Lindeblad; Larsen, Christian Grønhøj; Jensen, David H; Bork, Kristian; Sebbesen, Lars; Balle, Jesper; Fischer-Nielsen, Anne; von Buchwald, Christian.
In: PLOS ONE, Vol. 11, No. 9, e0162349, 2016.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mesenchymal Stem Cell Therapy for the Treatment of Vocal Fold Scarring
T2 - A Systematic Review of Preclinical Studies
AU - Wingstrand, Vibe Lindeblad
AU - Larsen, Christian Grønhøj
AU - Jensen, David H
AU - Bork, Kristian
AU - Sebbesen, Lars
AU - Balle, Jesper
AU - Fischer-Nielsen, Anne
AU - von Buchwald, Christian
PY - 2016
Y1 - 2016
N2 - OBJECTIVES: Therapy with mesenchymal stem cells exhibits potential for the development of novel interventions for many diseases and injuries. The use of mesenchymal stem cells in regenerative therapy for vocal fold scarring exhibited promising results to reduce stiffness and enhance the biomechanical properties of injured vocal folds. This study evaluated the biomechanical effects of mesenchymal stem cell therapy for the treatment of vocal fold scarring.DATA SOURCES: PubMed, Embase, the Cochrane Library and Google Scholar were searched.METHODS: Controlled studies that assessed the biomechanical effects of mesenchymal stem cell therapy for the treatment of vocal fold scarring were included. Primary outcomes were viscoelastic properties and mucosal wave amplitude.RESULTS: Seven preclinical animal studies (n = 152 single vocal folds) were eligible for inclusion. Evaluation of viscoelastic parameters revealed a decreased dynamic viscosity (η') and elastic modulus (G'), i.e., decreased resistance and stiffness, in scarred vocal folds treated with mesenchymal stem cells compared to non-treated scarred vocal folds. Mucosal wave amplitude was increased in scarred vocal folds treated with mesenchymal stem cells vs. non-treated scarred vocal folds.CONCLUSION: The results from these studies suggest an increased regenerative effect of therapy with mesenchymal stem cells for scarred vocal folds and are encouraging for further clinical studies.
AB - OBJECTIVES: Therapy with mesenchymal stem cells exhibits potential for the development of novel interventions for many diseases and injuries. The use of mesenchymal stem cells in regenerative therapy for vocal fold scarring exhibited promising results to reduce stiffness and enhance the biomechanical properties of injured vocal folds. This study evaluated the biomechanical effects of mesenchymal stem cell therapy for the treatment of vocal fold scarring.DATA SOURCES: PubMed, Embase, the Cochrane Library and Google Scholar were searched.METHODS: Controlled studies that assessed the biomechanical effects of mesenchymal stem cell therapy for the treatment of vocal fold scarring were included. Primary outcomes were viscoelastic properties and mucosal wave amplitude.RESULTS: Seven preclinical animal studies (n = 152 single vocal folds) were eligible for inclusion. Evaluation of viscoelastic parameters revealed a decreased dynamic viscosity (η') and elastic modulus (G'), i.e., decreased resistance and stiffness, in scarred vocal folds treated with mesenchymal stem cells compared to non-treated scarred vocal folds. Mucosal wave amplitude was increased in scarred vocal folds treated with mesenchymal stem cells vs. non-treated scarred vocal folds.CONCLUSION: The results from these studies suggest an increased regenerative effect of therapy with mesenchymal stem cells for scarred vocal folds and are encouraging for further clinical studies.
U2 - 10.1371/journal.pone.0162349
DO - 10.1371/journal.pone.0162349
M3 - Journal article
C2 - 27631373
VL - 11
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
M1 - e0162349
ER -
ID: 177436810