Meningioma–brain crosstalk: A scoping review
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Meningioma–brain crosstalk : A scoping review. / de Stricker Borch, Josefine; Haslund-Vinding, Jeppe; Vilhardt, Frederik; Maier, Andrea Daniela; Mathiesen, Tiit.
In: Cancers, Vol. 13, No. 17, 4267, 2021.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Meningioma–brain crosstalk
T2 - A scoping review
AU - de Stricker Borch, Josefine
AU - Haslund-Vinding, Jeppe
AU - Vilhardt, Frederik
AU - Maier, Andrea Daniela
AU - Mathiesen, Tiit
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Background: In recent years, it has become evident that the tumoral microenvironment (TME) plays a key role in the pathogenesis of various cancers. In meningiomas, however, the TME is poorly understood, and it is unknown if glia cells contribute to meningioma growth and behav-iour. Objective: This scoping review investigates if the literature describes and substantiates tu-mour–brain crosstalk in meningiomas and summarises the current evidence regarding the role of the brain parenchyma in the pathogenesis of meningiomas. Methods: We identified studies through the electronic database PubMed. Articles describing glia cells and cytokines/chemokines in menin-giomas were selected and reviewed. Results: Monocytes were detected as the most abundant infiltrating immune cells in meningiomas. Only brain-invasive meningiomas elicited a monocytic response at the tumour–brain interface. The expression of cytokines/chemokines in meningiomas has been studied to some extent, and some of them form autocrine loops in the tumour cells. Paracrine interactions between tumour cells and glia cells have not been explored. Conclusion: It is unknown to what extent meningiomas elicit an immune response in the brain parenchyma. We speculate that tumour–brain crosstalk might only be relevant in cases of invasive meningiomas that disrupt the pial–glial basement membrane.
AB - Background: In recent years, it has become evident that the tumoral microenvironment (TME) plays a key role in the pathogenesis of various cancers. In meningiomas, however, the TME is poorly understood, and it is unknown if glia cells contribute to meningioma growth and behav-iour. Objective: This scoping review investigates if the literature describes and substantiates tu-mour–brain crosstalk in meningiomas and summarises the current evidence regarding the role of the brain parenchyma in the pathogenesis of meningiomas. Methods: We identified studies through the electronic database PubMed. Articles describing glia cells and cytokines/chemokines in menin-giomas were selected and reviewed. Results: Monocytes were detected as the most abundant infiltrating immune cells in meningiomas. Only brain-invasive meningiomas elicited a monocytic response at the tumour–brain interface. The expression of cytokines/chemokines in meningiomas has been studied to some extent, and some of them form autocrine loops in the tumour cells. Paracrine interactions between tumour cells and glia cells have not been explored. Conclusion: It is unknown to what extent meningiomas elicit an immune response in the brain parenchyma. We speculate that tumour–brain crosstalk might only be relevant in cases of invasive meningiomas that disrupt the pial–glial basement membrane.
KW - Immune cells
KW - Inflammation
KW - Mac-rophage
KW - Meningioma
KW - Microglia
KW - Tumour microenvironment
U2 - 10.3390/cancers13174267
DO - 10.3390/cancers13174267
M3 - Review
C2 - 34503077
AN - SCOPUS:85113718772
VL - 13
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 17
M1 - 4267
ER -
ID: 279190520