Mendelian randomisation study of smoking exposure in relation to breast cancer risk

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Mendelian randomisation study of smoking exposure in relation to breast cancer risk. / Park, Hanla A.; Neumeyer, Sonja; Michailidou, Kyriaki; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Augustinsson, Annelie; Baten, Adinda; Beane Freeman, Laura E.; Becher, Heiko; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bogdanova, Natalia V.; Bojesen, Stig E.; Brauch, Hiltrud; Brenner, Hermann; Brucker, Sara Y.; Burwinkel, Barbara; Campa, Daniele; Canzian, Federico; Castelao, Jose E.; Chanock, Stephen J.; Chenevix-Trench, Georgia; Clarke, Christine L.; Børresen-Dale, Anne Lise; Grenaker Alnæs, Grethe I.; Sahlberg, Kristine K.; Ottestad, Lars; Kåresen, Rolf; Schlichting, Ellen; Holmen, Marit Muri; Sauer, Toril; Haakensen, Vilde; Engebråten, Olav; Naume, Bjørn; Fosså, Alexander; Kiserud, Cecile E.; Reinertsen, Kristin V.; Riis, Margit; Flyger, Henrik; Nordestgaard, Børge G.; Scott, Christopher; NBCS Collaborators; ABCTB Investigators; kConFab Investigators.

In: British Journal of Cancer, Vol. 125, 2021, p. 1135–1145.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Park, HA, Neumeyer, S, Michailidou, K, Bolla, MK, Wang, Q, Dennis, J, Ahearn, TU, Andrulis, IL, Anton-Culver, H, Antonenkova, NN, Arndt, V, Aronson, KJ, Augustinsson, A, Baten, A, Beane Freeman, LE, Becher, H, Beckmann, MW, Behrens, S, Benitez, J, Bermisheva, M, Bogdanova, NV, Bojesen, SE, Brauch, H, Brenner, H, Brucker, SY, Burwinkel, B, Campa, D, Canzian, F, Castelao, JE, Chanock, SJ, Chenevix-Trench, G, Clarke, CL, Børresen-Dale, AL, Grenaker Alnæs, GI, Sahlberg, KK, Ottestad, L, Kåresen, R, Schlichting, E, Holmen, MM, Sauer, T, Haakensen, V, Engebråten, O, Naume, B, Fosså, A, Kiserud, CE, Reinertsen, KV, Riis, M, Flyger, H, Nordestgaard, BG, Scott, C, NBCS Collaborators, ABCTB Investigators & kConFab Investigators 2021, 'Mendelian randomisation study of smoking exposure in relation to breast cancer risk', British Journal of Cancer, vol. 125, pp. 1135–1145. https://doi.org/10.1038/s41416-021-01432-8

APA

Park, H. A., Neumeyer, S., Michailidou, K., Bolla, M. K., Wang, Q., Dennis, J., Ahearn, T. U., Andrulis, I. L., Anton-Culver, H., Antonenkova, N. N., Arndt, V., Aronson, K. J., Augustinsson, A., Baten, A., Beane Freeman, L. E., Becher, H., Beckmann, M. W., Behrens, S., Benitez, J., ... kConFab Investigators (2021). Mendelian randomisation study of smoking exposure in relation to breast cancer risk. British Journal of Cancer, 125, 1135–1145. https://doi.org/10.1038/s41416-021-01432-8

Vancouver

Park HA, Neumeyer S, Michailidou K, Bolla MK, Wang Q, Dennis J et al. Mendelian randomisation study of smoking exposure in relation to breast cancer risk. British Journal of Cancer. 2021;125:1135–1145. https://doi.org/10.1038/s41416-021-01432-8

Author

Park, Hanla A. ; Neumeyer, Sonja ; Michailidou, Kyriaki ; Bolla, Manjeet K. ; Wang, Qin ; Dennis, Joe ; Ahearn, Thomas U. ; Andrulis, Irene L. ; Anton-Culver, Hoda ; Antonenkova, Natalia N. ; Arndt, Volker ; Aronson, Kristan J. ; Augustinsson, Annelie ; Baten, Adinda ; Beane Freeman, Laura E. ; Becher, Heiko ; Beckmann, Matthias W. ; Behrens, Sabine ; Benitez, Javier ; Bermisheva, Marina ; Bogdanova, Natalia V. ; Bojesen, Stig E. ; Brauch, Hiltrud ; Brenner, Hermann ; Brucker, Sara Y. ; Burwinkel, Barbara ; Campa, Daniele ; Canzian, Federico ; Castelao, Jose E. ; Chanock, Stephen J. ; Chenevix-Trench, Georgia ; Clarke, Christine L. ; Børresen-Dale, Anne Lise ; Grenaker Alnæs, Grethe I. ; Sahlberg, Kristine K. ; Ottestad, Lars ; Kåresen, Rolf ; Schlichting, Ellen ; Holmen, Marit Muri ; Sauer, Toril ; Haakensen, Vilde ; Engebråten, Olav ; Naume, Bjørn ; Fosså, Alexander ; Kiserud, Cecile E. ; Reinertsen, Kristin V. ; Riis, Margit ; Flyger, Henrik ; Nordestgaard, Børge G. ; Scott, Christopher ; NBCS Collaborators ; ABCTB Investigators ; kConFab Investigators. / Mendelian randomisation study of smoking exposure in relation to breast cancer risk. In: British Journal of Cancer. 2021 ; Vol. 125. pp. 1135–1145.

Bibtex

@article{d2d3cabadbbd4ca1a74f2cba164a2a4c,
title = "Mendelian randomisation study of smoking exposure in relation to breast cancer risk",
abstract = "Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07–1.30, P = 0.11 × 10–2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78–1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.",
author = "Park, {Hanla A.} and Sonja Neumeyer and Kyriaki Michailidou and Bolla, {Manjeet K.} and Qin Wang and Joe Dennis and Ahearn, {Thomas U.} and Andrulis, {Irene L.} and Hoda Anton-Culver and Antonenkova, {Natalia N.} and Volker Arndt and Aronson, {Kristan J.} and Annelie Augustinsson and Adinda Baten and {Beane Freeman}, {Laura E.} and Heiko Becher and Beckmann, {Matthias W.} and Sabine Behrens and Javier Benitez and Marina Bermisheva and Bogdanova, {Natalia V.} and Bojesen, {Stig E.} and Hiltrud Brauch and Hermann Brenner and Brucker, {Sara Y.} and Barbara Burwinkel and Daniele Campa and Federico Canzian and Castelao, {Jose E.} and Chanock, {Stephen J.} and Georgia Chenevix-Trench and Clarke, {Christine L.} and B{\o}rresen-Dale, {Anne Lise} and {Grenaker Aln{\ae}s}, {Grethe I.} and Sahlberg, {Kristine K.} and Lars Ottestad and Rolf K{\aa}resen and Ellen Schlichting and Holmen, {Marit Muri} and Toril Sauer and Vilde Haakensen and Olav Engebr{\aa}ten and Bj{\o}rn Naume and Alexander Foss{\aa} and Kiserud, {Cecile E.} and Reinertsen, {Kristin V.} and Margit Riis and Henrik Flyger and Nordestgaard, {B{\o}rge G.} and Christopher Scott and {NBCS Collaborators} and {ABCTB Investigators} and {kConFab Investigators}",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
doi = "10.1038/s41416-021-01432-8",
language = "English",
volume = "125",
pages = "1135–1145",
journal = "The British journal of cancer. Supplement",
issn = "0007-0920",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Mendelian randomisation study of smoking exposure in relation to breast cancer risk

AU - Park, Hanla A.

AU - Neumeyer, Sonja

AU - Michailidou, Kyriaki

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Dennis, Joe

AU - Ahearn, Thomas U.

AU - Andrulis, Irene L.

AU - Anton-Culver, Hoda

AU - Antonenkova, Natalia N.

AU - Arndt, Volker

AU - Aronson, Kristan J.

AU - Augustinsson, Annelie

AU - Baten, Adinda

AU - Beane Freeman, Laura E.

AU - Becher, Heiko

AU - Beckmann, Matthias W.

AU - Behrens, Sabine

AU - Benitez, Javier

AU - Bermisheva, Marina

AU - Bogdanova, Natalia V.

AU - Bojesen, Stig E.

AU - Brauch, Hiltrud

AU - Brenner, Hermann

AU - Brucker, Sara Y.

AU - Burwinkel, Barbara

AU - Campa, Daniele

AU - Canzian, Federico

AU - Castelao, Jose E.

AU - Chanock, Stephen J.

AU - Chenevix-Trench, Georgia

AU - Clarke, Christine L.

AU - Børresen-Dale, Anne Lise

AU - Grenaker Alnæs, Grethe I.

AU - Sahlberg, Kristine K.

AU - Ottestad, Lars

AU - Kåresen, Rolf

AU - Schlichting, Ellen

AU - Holmen, Marit Muri

AU - Sauer, Toril

AU - Haakensen, Vilde

AU - Engebråten, Olav

AU - Naume, Bjørn

AU - Fosså, Alexander

AU - Kiserud, Cecile E.

AU - Reinertsen, Kristin V.

AU - Riis, Margit

AU - Flyger, Henrik

AU - Nordestgaard, Børge G.

AU - Scott, Christopher

AU - NBCS Collaborators

AU - ABCTB Investigators

AU - kConFab Investigators

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2021

Y1 - 2021

N2 - Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07–1.30, P = 0.11 × 10–2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78–1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.

AB - Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results: Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07–1.30, P = 0.11 × 10–2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78–1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion: Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.

U2 - 10.1038/s41416-021-01432-8

DO - 10.1038/s41416-021-01432-8

M3 - Journal article

C2 - 34341517

AN - SCOPUS:85112658433

VL - 125

SP - 1135

EP - 1145

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

SN - 0007-0920

ER -

ID: 277226520