Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 5: Lincosamides: lincomycin
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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 5: Lincosamides: lincomycin. / EFSA Panel on Biological Hazards (BIOHAZ); Koutsoumanis, Konstantinos; Allende, Ana; Alvarez-Ordóñez, Avelino; Bolton, Declan; Bover-Cid, Sara; Chemaly, Marianne; Davies, Robert; De Cesare, Alessandra; Herman, Lieve; Hilbert, Friederike; Lindqvist, Roland; Nauta, Maarten; Ru, Giuseppe; Simmons, Marion; Skandamis, Panagiotis; Suffredini, Elisabetta; Andersson, Dan I; Bampidis, Vasileios; Bengtsson-Palme, Johan; Bouchard, Damien; Ferran, Aude; Kouba, Maryline; López Puente, Secundino; López-Alonso, Marta; Nielsen, Søren Saxmose; Pechová, Alena; Petkova, Mariana; Girault, Sebastien; Broglia, Alessandro; Guerra, Beatriz; Innocenti, Matteo Lorenzo; Liébana, Ernesto; López-Gálvez, Gloria; Manini, Paola; Stella, Pietro; Peixe, Luisa.
In: EFSA Journal, Vol. 19, No. 10, e06856, 26.10.2021, p. 1-22.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 5: Lincosamides: lincomycin
AU - EFSA Panel on Biological Hazards (BIOHAZ), null
AU - Koutsoumanis, Konstantinos
AU - Allende, Ana
AU - Alvarez-Ordóñez, Avelino
AU - Bolton, Declan
AU - Bover-Cid, Sara
AU - Chemaly, Marianne
AU - Davies, Robert
AU - De Cesare, Alessandra
AU - Herman, Lieve
AU - Hilbert, Friederike
AU - Lindqvist, Roland
AU - Nauta, Maarten
AU - Ru, Giuseppe
AU - Simmons, Marion
AU - Skandamis, Panagiotis
AU - Suffredini, Elisabetta
AU - Andersson, Dan I
AU - Bampidis, Vasileios
AU - Bengtsson-Palme, Johan
AU - Bouchard, Damien
AU - Ferran, Aude
AU - Kouba, Maryline
AU - López Puente, Secundino
AU - López-Alonso, Marta
AU - Nielsen, Søren Saxmose
AU - Pechová, Alena
AU - Petkova, Mariana
AU - Girault, Sebastien
AU - Broglia, Alessandro
AU - Guerra, Beatriz
AU - Innocenti, Matteo Lorenzo
AU - Liébana, Ernesto
AU - López-Gálvez, Gloria
AU - Manini, Paola
AU - Stella, Pietro
AU - Peixe, Luisa
PY - 2021/10/26
Y1 - 2021/10/26
N2 - Abstract The specific concentrations of lincomycin in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of lincomycin in feed that showed to have an effect on growth promotion/increased yield were reported. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for lincomycin.
AB - Abstract The specific concentrations of lincomycin in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of lincomycin in feed that showed to have an effect on growth promotion/increased yield were reported. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for lincomycin.
KW - lincomycin
KW - antimicrobial resistance
KW - sub-inhibitory concentration
KW - Feed Antimicrobial Resistance Selection Concentration (FARSC)
KW - growth promotion
KW - yield increase
KW - food-producing animals
U2 - 10.2903/j.efsa.2021.6856
DO - 10.2903/j.efsa.2021.6856
M3 - Journal article
C2 - 34729085
VL - 19
SP - 1
EP - 22
JO - E F S A Journal
JF - E F S A Journal
SN - 1831-4732
IS - 10
M1 - e06856
ER -
ID: 282611039