Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients
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Homozygous carriage of a 14 base pair (bp) insertion in exon 8 of the HLA-G gene may be associated with low levels of soluble HLA-G and recurrent miscarriage (RM). We investigated the G14bp insertion(ins)/deletion(del) polymorphism in 339 women with unexplained RM and 125 control women. In all patients and patients with secondary RM after a firstborn boy, 19.2% and 23.9%, respectively, were G14bp ins/ins compared with 11.2% of controls (p
| Original language | English |
|---|---|
| Journal | Human Immunology |
| Volume | 73 |
| Issue number | 7 |
| Pages (from-to) | 699-705 |
| Number of pages | 7 |
| ISSN | 0198-8859 |
| DOIs | |
| Publication status | Published - Jul 2012 |
- Abortion, Habitual, Alleles, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, H-Y Antigen, HLA-G Antigens, Histocompatibility Antigens Class II, Homozygote, Humans, Immunity, Infant, Low Birth Weight, Infant, Newborn, Male, Mutagenesis, Insertional, Polymorphism, Genetic, Protein Binding
Research areas
ID: 47923510