Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: a systematic review and dose–response meta-analysis
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Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters : a systematic review and dose–response meta-analysis. / Saxov, Kristina Rantzau; Strandberg-Larsen, Katrine; Pristed, Sofie G.; Bruun, Niels Henrik; Kesmodel, Ulrik Schiøler.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 102, No. 7, 2023, p. 821-832.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters
T2 - a systematic review and dose–response meta-analysis
AU - Saxov, Kristina Rantzau
AU - Strandberg-Larsen, Katrine
AU - Pristed, Sofie G.
AU - Bruun, Niels Henrik
AU - Kesmodel, Ulrik Schiøler
N1 - Publisher Copyright: © 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).
PY - 2023
Y1 - 2023
N2 - Introduction: According to a precautionary principle, it is recommended that pregnant women and women trying to conceive abstain from alcohol consumption. In this dose–response meta-analysis, we aimed to examine the association between alcohol consumption and binge drinking and the risk of miscarriage in the first and second trimesters. Material and methods: The literature search was conducted in MEDLINE, Embase and the Cochrane Library in May 2022, without any language, geographic or time limitations. Cohort or case–control studies reporting dose-specific effects adjusting for maternal age and using separate risk assessments for first- and second-trimester miscarriages were included. Study quality was assessed using the Newcastle–Ottawa Scale. This study is registered with PROSPERO, registration number CRD42020221070. Results: A total of 2124 articles were identified. Five articles met the inclusion criteria. Adjusted data from 153 619 women were included in the first-trimester analysis and data from 458 154 women in the second-trimester analysis. In the first and second trimesters, the risk of miscarriage increased by 7% (odds ratio [OR] 1.07, 95% confidence interval [CI] 0.96–1.20) and 3% (OR 1.03, 95% CI 0.99–1.08) for each additional drink per week, respectively, but not to a statistically significant degree. One article regarding binge drinking and the risk of miscarriage was found, which revealed no association between the variables in either the first or second trimester (OR 0.84 [95% CI 0.62–1.14] and OR 1.04 [95% CI 0.78–1.38]). Conclusions: This meta-analysis revealed no dose-dependent association between miscarriage risk and alcohol consumption, but further focused research is recommended. The research gap regarding miscarriage and binge drinking needs further investigation.
AB - Introduction: According to a precautionary principle, it is recommended that pregnant women and women trying to conceive abstain from alcohol consumption. In this dose–response meta-analysis, we aimed to examine the association between alcohol consumption and binge drinking and the risk of miscarriage in the first and second trimesters. Material and methods: The literature search was conducted in MEDLINE, Embase and the Cochrane Library in May 2022, without any language, geographic or time limitations. Cohort or case–control studies reporting dose-specific effects adjusting for maternal age and using separate risk assessments for first- and second-trimester miscarriages were included. Study quality was assessed using the Newcastle–Ottawa Scale. This study is registered with PROSPERO, registration number CRD42020221070. Results: A total of 2124 articles were identified. Five articles met the inclusion criteria. Adjusted data from 153 619 women were included in the first-trimester analysis and data from 458 154 women in the second-trimester analysis. In the first and second trimesters, the risk of miscarriage increased by 7% (odds ratio [OR] 1.07, 95% confidence interval [CI] 0.96–1.20) and 3% (OR 1.03, 95% CI 0.99–1.08) for each additional drink per week, respectively, but not to a statistically significant degree. One article regarding binge drinking and the risk of miscarriage was found, which revealed no association between the variables in either the first or second trimester (OR 0.84 [95% CI 0.62–1.14] and OR 1.04 [95% CI 0.78–1.38]). Conclusions: This meta-analysis revealed no dose-dependent association between miscarriage risk and alcohol consumption, but further focused research is recommended. The research gap regarding miscarriage and binge drinking needs further investigation.
KW - alcohol consumption
KW - binge drinking
KW - miscarriage
KW - pregnancy
KW - spontaneous abortion
U2 - 10.1111/aogs.14566
DO - 10.1111/aogs.14566
M3 - Review
C2 - 37221907
AN - SCOPUS:85160070496
VL - 102
SP - 821
EP - 832
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 7
ER -
ID: 351941167