Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: a systematic review and dose–response meta-analysis

Research output: Contribution to journalReviewpeer-review

Standard

Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters : a systematic review and dose–response meta-analysis. / Saxov, Kristina Rantzau; Strandberg-Larsen, Katrine; Pristed, Sofie G.; Bruun, Niels Henrik; Kesmodel, Ulrik Schiøler.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 102, No. 7, 2023, p. 821-832.

Research output: Contribution to journalReviewpeer-review

Harvard

Saxov, KR, Strandberg-Larsen, K, Pristed, SG, Bruun, NH & Kesmodel, US 2023, 'Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: a systematic review and dose–response meta-analysis', Acta Obstetricia et Gynecologica Scandinavica, vol. 102, no. 7, pp. 821-832. https://doi.org/10.1111/aogs.14566

APA

Saxov, K. R., Strandberg-Larsen, K., Pristed, S. G., Bruun, NH., & Kesmodel, U. S. (2023). Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: a systematic review and dose–response meta-analysis. Acta Obstetricia et Gynecologica Scandinavica, 102(7), 821-832. https://doi.org/10.1111/aogs.14566

Vancouver

Saxov KR, Strandberg-Larsen K, Pristed SG, Bruun NH, Kesmodel US. Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: a systematic review and dose–response meta-analysis. Acta Obstetricia et Gynecologica Scandinavica. 2023;102(7): 821-832. https://doi.org/10.1111/aogs.14566

Author

Saxov, Kristina Rantzau ; Strandberg-Larsen, Katrine ; Pristed, Sofie G. ; Bruun, Niels Henrik ; Kesmodel, Ulrik Schiøler. / Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters : a systematic review and dose–response meta-analysis. In: Acta Obstetricia et Gynecologica Scandinavica. 2023 ; Vol. 102, No. 7. pp. 821-832.

Bibtex

@article{5cb43520d83a44eeb60b25aafec89251,
title = "Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters: a systematic review and dose–response meta-analysis",
abstract = "Introduction: According to a precautionary principle, it is recommended that pregnant women and women trying to conceive abstain from alcohol consumption. In this dose–response meta-analysis, we aimed to examine the association between alcohol consumption and binge drinking and the risk of miscarriage in the first and second trimesters. Material and methods: The literature search was conducted in MEDLINE, Embase and the Cochrane Library in May 2022, without any language, geographic or time limitations. Cohort or case–control studies reporting dose-specific effects adjusting for maternal age and using separate risk assessments for first- and second-trimester miscarriages were included. Study quality was assessed using the Newcastle–Ottawa Scale. This study is registered with PROSPERO, registration number CRD42020221070. Results: A total of 2124 articles were identified. Five articles met the inclusion criteria. Adjusted data from 153 619 women were included in the first-trimester analysis and data from 458 154 women in the second-trimester analysis. In the first and second trimesters, the risk of miscarriage increased by 7% (odds ratio [OR] 1.07, 95% confidence interval [CI] 0.96–1.20) and 3% (OR 1.03, 95% CI 0.99–1.08) for each additional drink per week, respectively, but not to a statistically significant degree. One article regarding binge drinking and the risk of miscarriage was found, which revealed no association between the variables in either the first or second trimester (OR 0.84 [95% CI 0.62–1.14] and OR 1.04 [95% CI 0.78–1.38]). Conclusions: This meta-analysis revealed no dose-dependent association between miscarriage risk and alcohol consumption, but further focused research is recommended. The research gap regarding miscarriage and binge drinking needs further investigation.",
keywords = "alcohol consumption, binge drinking, miscarriage, pregnancy, spontaneous abortion",
author = "Saxov, {Kristina Rantzau} and Katrine Strandberg-Larsen and Pristed, {Sofie G.} and Niels Henrik Bruun and Kesmodel, {Ulrik Schi{\o}ler}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).",
year = "2023",
doi = "10.1111/aogs.14566",
language = "English",
volume = "102",
pages = " 821--832",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
publisher = "JohnWiley & Sons Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Maternal alcohol consumption and the risk of miscarriage in the first and second trimesters

T2 - a systematic review and dose–response meta-analysis

AU - Saxov, Kristina Rantzau

AU - Strandberg-Larsen, Katrine

AU - Pristed, Sofie G.

AU - Bruun, Niels Henrik

AU - Kesmodel, Ulrik Schiøler

N1 - Publisher Copyright: © 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).

PY - 2023

Y1 - 2023

N2 - Introduction: According to a precautionary principle, it is recommended that pregnant women and women trying to conceive abstain from alcohol consumption. In this dose–response meta-analysis, we aimed to examine the association between alcohol consumption and binge drinking and the risk of miscarriage in the first and second trimesters. Material and methods: The literature search was conducted in MEDLINE, Embase and the Cochrane Library in May 2022, without any language, geographic or time limitations. Cohort or case–control studies reporting dose-specific effects adjusting for maternal age and using separate risk assessments for first- and second-trimester miscarriages were included. Study quality was assessed using the Newcastle–Ottawa Scale. This study is registered with PROSPERO, registration number CRD42020221070. Results: A total of 2124 articles were identified. Five articles met the inclusion criteria. Adjusted data from 153 619 women were included in the first-trimester analysis and data from 458 154 women in the second-trimester analysis. In the first and second trimesters, the risk of miscarriage increased by 7% (odds ratio [OR] 1.07, 95% confidence interval [CI] 0.96–1.20) and 3% (OR 1.03, 95% CI 0.99–1.08) for each additional drink per week, respectively, but not to a statistically significant degree. One article regarding binge drinking and the risk of miscarriage was found, which revealed no association between the variables in either the first or second trimester (OR 0.84 [95% CI 0.62–1.14] and OR 1.04 [95% CI 0.78–1.38]). Conclusions: This meta-analysis revealed no dose-dependent association between miscarriage risk and alcohol consumption, but further focused research is recommended. The research gap regarding miscarriage and binge drinking needs further investigation.

AB - Introduction: According to a precautionary principle, it is recommended that pregnant women and women trying to conceive abstain from alcohol consumption. In this dose–response meta-analysis, we aimed to examine the association between alcohol consumption and binge drinking and the risk of miscarriage in the first and second trimesters. Material and methods: The literature search was conducted in MEDLINE, Embase and the Cochrane Library in May 2022, without any language, geographic or time limitations. Cohort or case–control studies reporting dose-specific effects adjusting for maternal age and using separate risk assessments for first- and second-trimester miscarriages were included. Study quality was assessed using the Newcastle–Ottawa Scale. This study is registered with PROSPERO, registration number CRD42020221070. Results: A total of 2124 articles were identified. Five articles met the inclusion criteria. Adjusted data from 153 619 women were included in the first-trimester analysis and data from 458 154 women in the second-trimester analysis. In the first and second trimesters, the risk of miscarriage increased by 7% (odds ratio [OR] 1.07, 95% confidence interval [CI] 0.96–1.20) and 3% (OR 1.03, 95% CI 0.99–1.08) for each additional drink per week, respectively, but not to a statistically significant degree. One article regarding binge drinking and the risk of miscarriage was found, which revealed no association between the variables in either the first or second trimester (OR 0.84 [95% CI 0.62–1.14] and OR 1.04 [95% CI 0.78–1.38]). Conclusions: This meta-analysis revealed no dose-dependent association between miscarriage risk and alcohol consumption, but further focused research is recommended. The research gap regarding miscarriage and binge drinking needs further investigation.

KW - alcohol consumption

KW - binge drinking

KW - miscarriage

KW - pregnancy

KW - spontaneous abortion

U2 - 10.1111/aogs.14566

DO - 10.1111/aogs.14566

M3 - Review

C2 - 37221907

AN - SCOPUS:85160070496

VL - 102

SP - 821

EP - 832

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 7

ER -

ID: 351941167