Mammalian RNA polymerase II core promoters: insights from genome-wide studies.

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Mammalian RNA polymerase II core promoters: insights from genome-wide studies. / Sandelin, Albin; Carninci, Piero; Lenhard, Boris; Ponjavic, Jasmina; Hayashizaki, Yoshihide; Hume, David A.

In: Nature Reviews. Genetics, Vol. 8, No. 6, 2007, p. 424-36.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sandelin, A, Carninci, P, Lenhard, B, Ponjavic, J, Hayashizaki, Y & Hume, DA 2007, 'Mammalian RNA polymerase II core promoters: insights from genome-wide studies.', Nature Reviews. Genetics, vol. 8, no. 6, pp. 424-36. https://doi.org/10.1038/nrg2026

APA

Sandelin, A., Carninci, P., Lenhard, B., Ponjavic, J., Hayashizaki, Y., & Hume, D. A. (2007). Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nature Reviews. Genetics, 8(6), 424-36. https://doi.org/10.1038/nrg2026

Vancouver

Sandelin A, Carninci P, Lenhard B, Ponjavic J, Hayashizaki Y, Hume DA. Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nature Reviews. Genetics. 2007;8(6):424-36. https://doi.org/10.1038/nrg2026

Author

Sandelin, Albin ; Carninci, Piero ; Lenhard, Boris ; Ponjavic, Jasmina ; Hayashizaki, Yoshihide ; Hume, David A. / Mammalian RNA polymerase II core promoters: insights from genome-wide studies. In: Nature Reviews. Genetics. 2007 ; Vol. 8, No. 6. pp. 424-36.

Bibtex

@article{f5bc3c60991511dd86a6000ea68e967b,

title = "Mammalian RNA polymerase II core promoters: insights from genome-wide studies.",

abstract = "The identification and characterization of mammalian core promoters and transcription start sites is a prerequisite to understanding how RNA polymerase II transcription is controlled. New experimental technologies have enabled genome-wide discovery and characterization of core promoters, revealing that most mammalian genes do not conform to the simple model in which a TATA box directs transcription from a single defined nucleotide position. In fact, most genes have multiple promoters, within which there are multiple start sites, and alternative promoter usage generates diversity and complexity in the mammalian transcriptome and proteome. Promoters can be described by their start site usage distribution, which is coupled to the occurrence of cis-regulatory elements, gene function and evolutionary constraints. A comprehensive survey of mammalian promoters is a major step towards describing and understanding transcriptional control networks.",

author = "Albin Sandelin and Piero Carninci and Boris Lenhard and Jasmina Ponjavic and Yoshihide Hayashizaki and Hume, {David A}",

note = "Keywords: 3' Untranslated Regions; Animals; Chromatin Immunoprecipitation; CpG Islands; Evolution, Molecular; Genome; Genome, Human; Humans; Mice; Promoter Regions (Genetics); RNA Polymerase II; TATA Box; Transcription Initiation Site",

year = "2007",

doi = "10.1038/nrg2026",

language = "English",

volume = "8",

pages = "424--36",

journal = "Nature Reviews. Genetics",

issn = "1471-0056",

publisher = "nature publishing group",

number = "6",

}

RIS

TY - JOUR

T1 - Mammalian RNA polymerase II core promoters: insights from genome-wide studies.

AU - Sandelin, Albin

AU - Carninci, Piero

AU - Lenhard, Boris

AU - Ponjavic, Jasmina

AU - Hayashizaki, Yoshihide

AU - Hume, David A

N1 - Keywords: 3' Untranslated Regions; Animals; Chromatin Immunoprecipitation; CpG Islands; Evolution, Molecular; Genome; Genome, Human; Humans; Mice; Promoter Regions (Genetics); RNA Polymerase II; TATA Box; Transcription Initiation Site

PY - 2007

Y1 - 2007

N2 - The identification and characterization of mammalian core promoters and transcription start sites is a prerequisite to understanding how RNA polymerase II transcription is controlled. New experimental technologies have enabled genome-wide discovery and characterization of core promoters, revealing that most mammalian genes do not conform to the simple model in which a TATA box directs transcription from a single defined nucleotide position. In fact, most genes have multiple promoters, within which there are multiple start sites, and alternative promoter usage generates diversity and complexity in the mammalian transcriptome and proteome. Promoters can be described by their start site usage distribution, which is coupled to the occurrence of cis-regulatory elements, gene function and evolutionary constraints. A comprehensive survey of mammalian promoters is a major step towards describing and understanding transcriptional control networks.

AB - The identification and characterization of mammalian core promoters and transcription start sites is a prerequisite to understanding how RNA polymerase II transcription is controlled. New experimental technologies have enabled genome-wide discovery and characterization of core promoters, revealing that most mammalian genes do not conform to the simple model in which a TATA box directs transcription from a single defined nucleotide position. In fact, most genes have multiple promoters, within which there are multiple start sites, and alternative promoter usage generates diversity and complexity in the mammalian transcriptome and proteome. Promoters can be described by their start site usage distribution, which is coupled to the occurrence of cis-regulatory elements, gene function and evolutionary constraints. A comprehensive survey of mammalian promoters is a major step towards describing and understanding transcriptional control networks.

U2 - 10.1038/nrg2026

DO - 10.1038/nrg2026

M3 - Journal article

C2 - 17486122

VL - 8

SP - 424

EP - 436

JO - Nature Reviews. Genetics

JF - Nature Reviews. Genetics

SN - 1471-0056

IS - 6

ER -

ID: 6566511