Major depressive symptoms increase 3-year mortality rate in patients with mild dementia
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Major depressive symptoms increase 3-year mortality rate in patients with mild dementia. / Petersen, Jindong Ding; Waldorff, Frans Boch; Siersma, Volkert Dirk; Phung, Thien Kieu Thi; Bebe, Anna Carina Klara Magdalena; Waldemar, Gunhild.
In: International Journal of Alzheimer's Disease, Vol. 2017, 7482094, 06.04.2017, p. 1-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Major depressive symptoms increase 3-year mortality rate in patients with mild dementia
AU - Petersen, Jindong Ding
AU - Waldorff, Frans Boch
AU - Siersma, Volkert Dirk
AU - Phung, Thien Kieu Thi
AU - Bebe, Anna Carina Klara Magdalena
AU - Waldemar, Gunhild
PY - 2017/4/6
Y1 - 2017/4/6
N2 - Depression and dementia are commonly concurrent and are both associated with increased mortality among older people. However, little is known about whether home-dwelling patients newly diagnosed with mild dementia coexisting with depressive symptoms have excess mortality. We conducted a post hoc analysis based on data from the Danish Alzheimer's Intervention Study of 330 individuals who were diagnosed with mild dementia within the past 12 months. Thirty-four patients were identified with major depressive symptoms (MD-S) at baseline. During the 3-year follow-up period, 56 patients died, and, among them, 12 were with MD-S at baseline. Multivariable analysis adjusting for the potential confounders (age, sex, smoking status, alcohol consumption, education, BMI, household status, MMSE, CCI, QoL-AD, NPIQ, ADSC-ADL, medication, and RCT allocation) showed that patients with MD-S had a 2.5-fold higher mortality as compared to the patients without or with only few depressive symptoms. Our result revealed that depression is possibly associated with increased mortality in patients with mild dementia. Given that depression is treatable, screening for depression and treatment of depression can be important already in the earliest stage of dementia to reduce mortality.
AB - Depression and dementia are commonly concurrent and are both associated with increased mortality among older people. However, little is known about whether home-dwelling patients newly diagnosed with mild dementia coexisting with depressive symptoms have excess mortality. We conducted a post hoc analysis based on data from the Danish Alzheimer's Intervention Study of 330 individuals who were diagnosed with mild dementia within the past 12 months. Thirty-four patients were identified with major depressive symptoms (MD-S) at baseline. During the 3-year follow-up period, 56 patients died, and, among them, 12 were with MD-S at baseline. Multivariable analysis adjusting for the potential confounders (age, sex, smoking status, alcohol consumption, education, BMI, household status, MMSE, CCI, QoL-AD, NPIQ, ADSC-ADL, medication, and RCT allocation) showed that patients with MD-S had a 2.5-fold higher mortality as compared to the patients without or with only few depressive symptoms. Our result revealed that depression is possibly associated with increased mortality in patients with mild dementia. Given that depression is treatable, screening for depression and treatment of depression can be important already in the earliest stage of dementia to reduce mortality.
UR - http://www.scopus.com/inward/record.url?scp=85018801455&partnerID=8YFLogxK
U2 - 10.1155/2017/7482094
DO - 10.1155/2017/7482094
M3 - Journal article
C2 - 28484660
AN - SCOPUS:85018801455
VL - 2017
SP - 1
EP - 9
JO - International Journal of Alzheimer's Disease
JF - International Journal of Alzheimer's Disease
SN - 2090-8024
M1 - 7482094
ER -
ID: 189624688