Lymphoproliferative responses to Plasmodium falciparum antigens in children with and without the sickle cell trait
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Lymphoproliferative responses to Plasmodium falciparum antigens in children with and without the sickle cell trait. / Abu-Zeid, Y A; Abdulhadi, N H; Hviid, L; Theander, T G; Saeed, B O; Jepsen, S; Jensen, J B; Bayoumi, R A.
In: Scandinavian Journal of Immunology, Vol. 34, No. 2, 1991, p. 237-42.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lymphoproliferative responses to Plasmodium falciparum antigens in children with and without the sickle cell trait
AU - Abu-Zeid, Y A
AU - Abdulhadi, N H
AU - Hviid, L
AU - Theander, T G
AU - Saeed, B O
AU - Jepsen, S
AU - Jensen, J B
AU - Bayoumi, R A
N1 - Keywords: Animals; Antigens, Protozoan; Child; Humans; Immunologic Memory; Lymphocyte Activation; Malaria; Phytohemagglutinins; Plasmodium falciparum; Sickle Cell Trait; Tuberculin
PY - 1991
Y1 - 1991
N2 - Blood mononuclear cells (BMNC) were isolated from sickle cell trait (HbAS) healthy donors and normal haemoglobin (HbAA) healthy donors resident in a P. falciparum endemic area of eastern Sudan. Blood samples were collected during the malaria season. BMNC were tested for their proliferative responses to phytohaemagglutinin (PHA), purified protein derivative of tuberculin (PPD) and to soluble P. falciparum antigens (SPAg). Higher responses to SPAg and PPD were observed in the HbAS children compared with the HbAA children, whereas no differences were observed among adults of the two phenotypes. Proliferative responses to PHA were comparable in all individuals tested. The significance of these findings in relation to haemoglobin phenotype, age and the possible immunoregulatory mechanisms operating in HbAS and HbAA children during the malaria season is discussed.
AB - Blood mononuclear cells (BMNC) were isolated from sickle cell trait (HbAS) healthy donors and normal haemoglobin (HbAA) healthy donors resident in a P. falciparum endemic area of eastern Sudan. Blood samples were collected during the malaria season. BMNC were tested for their proliferative responses to phytohaemagglutinin (PHA), purified protein derivative of tuberculin (PPD) and to soluble P. falciparum antigens (SPAg). Higher responses to SPAg and PPD were observed in the HbAS children compared with the HbAA children, whereas no differences were observed among adults of the two phenotypes. Proliferative responses to PHA were comparable in all individuals tested. The significance of these findings in relation to haemoglobin phenotype, age and the possible immunoregulatory mechanisms operating in HbAS and HbAA children during the malaria season is discussed.
M3 - Journal article
C2 - 1866602
VL - 34
SP - 237
EP - 242
JO - Scandinavian Journal of Immunology, Supplement
JF - Scandinavian Journal of Immunology, Supplement
SN - 0301-6323
IS - 2
ER -
ID: 6748508