Long-term influences of body-weight changes, independent of the attained weight, on risk of impaired glucose tolerance and Type 2 diabetes
Research output: Contribution to journal › Journal article › Research › peer-review
AIM: To investigate if weight gain during adulthood has effects on the risk of developing impaired glucose tolerance (IGT) or Type 2 diabetes beyond effect of attained weight. RESEARCH DESIGN AND METHODS: Data were obtained from a longitudinal study of two cohorts: one of juvenile-onset obese (n = 248) and one of randomly selected control (n = 320) men, weighed at average ages of 20, 33, 44 and 51 years, respectively. RESULTS: For any given BMI, the risk of IGT was higher the greater the weight gain since age 20 (odds ratio of 1.10 per unit kg/m2 of BMI gain, confidence interval 1.03-1.17, P = 0.004), and weight gain during both the early and later ages contributed to the increased risk. Obese men, maintaining weight since age 20, had lower risk of IGT than non-obese men who became similarly obese by age 51. The risk of Type 2 diabetes increased by weight gain in early adult life, but not by more recent weight gain in the later periods, probably because of the development of Type 2 diabetes leading to weight loss. CONCLUSIONS: Independent of attained level of body weight in middle-aged men, weight gain is associated with increased risk of IGT, and is greater in those not overweight in childhood.
Original language | English |
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Journal | Diabetic Medicine |
Volume | 22 |
Issue number | 9 |
Pages (from-to) | 1199-1205 |
Number of pages | 6 |
ISSN | 0742-3071 |
DOIs | |
Publication status | Published - 2005 |
Bibliographical note
Keywords: Adult; Aging; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Glucose Intolerance; Glucose Tolerance Test; Humans; Longitudinal Studies; Male; Middle Aged; Obesity; Prevalence; Risk Factors; Weight Gain
ID: 12389304