Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project
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Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project. / Andersen, Zorana J.; Stafoggia, Massimo; Weinmayr, Gudrun; Pedersen, Marie; Galassi, Claudia; Jørgensen, Jeanette T.; Oudin, Anna; Forsberg, Bertil; Olsson, David; Oftedal, Bente; Marit Aasvang, Gunn; Aamodt, Geir; Pyko, Andrei; Pershagen, Göran; Korek, Michal; De Faire, Ulf; Pedersen, Nancy L; Östenson, Claes-Göran; Fratiglioni, Laura; Eriksen, Kirsten T.; Tjønneland, Anne; Peeters, Petra H; Bueno-de-Mesquita, Bas; Plusquin, Michelle; Key, Timothy J; Jaensch, Andrea; Nagel, Gabriele; Lang, Alois; Wang, Meng; Tsai, Ming-Yi; Fournier, Agnes; Boutron-Ruault, Marie-Christine; Baglietto, Laura; Grioni, Sara; Marcon, Alessandro; Krogh, Vittorio; Ricceri, Fulvio; Sacerdote, Carlotta; Migliore, Enrica; Tamayo-Uria, Ibon; Amiano, Pilar; Dorronsoro, Miren; Vermeulen, Roel; Sokhi, Ranjeet; Keuken, Menno; de Hoogh, Kees; Beelen, Rob; Vineis, Paolo; Cesaroni, Giulia; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.
In: Environmental Health Perspectives, Vol. 125, No. 10, 107005, 13.10.2017, p. 1-14.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project
AU - Andersen, Zorana J.
AU - Stafoggia, Massimo
AU - Weinmayr, Gudrun
AU - Pedersen, Marie
AU - Galassi, Claudia
AU - Jørgensen, Jeanette T.
AU - Oudin, Anna
AU - Forsberg, Bertil
AU - Olsson, David
AU - Oftedal, Bente
AU - Marit Aasvang, Gunn
AU - Aamodt, Geir
AU - Pyko, Andrei
AU - Pershagen, Göran
AU - Korek, Michal
AU - De Faire, Ulf
AU - Pedersen, Nancy L
AU - Östenson, Claes-Göran
AU - Fratiglioni, Laura
AU - Eriksen, Kirsten T.
AU - Tjønneland, Anne
AU - Peeters, Petra H
AU - Bueno-de-Mesquita, Bas
AU - Plusquin, Michelle
AU - Key, Timothy J
AU - Jaensch, Andrea
AU - Nagel, Gabriele
AU - Lang, Alois
AU - Wang, Meng
AU - Tsai, Ming-Yi
AU - Fournier, Agnes
AU - Boutron-Ruault, Marie-Christine
AU - Baglietto, Laura
AU - Grioni, Sara
AU - Marcon, Alessandro
AU - Krogh, Vittorio
AU - Ricceri, Fulvio
AU - Sacerdote, Carlotta
AU - Migliore, Enrica
AU - Tamayo-Uria, Ibon
AU - Amiano, Pilar
AU - Dorronsoro, Miren
AU - Vermeulen, Roel
AU - Sokhi, Ranjeet
AU - Keuken, Menno
AU - de Hoogh, Kees
AU - Beelen, Rob
AU - Vineis, Paolo
AU - Cesaroni, Giulia
AU - Brunekreef, Bert
AU - Hoek, Gerard
AU - Raaschou-Nielsen, Ole
PY - 2017/10/13
Y1 - 2017/10/13
N2 - BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.
AB - BACKGROUND: Epidemiological evidence on the association between ambient air pollution and breast cancer risk is inconsistent.OBJECTIVE: We examined the association between long-term exposure to ambient air pollution and incidence of postmenopausal breast cancer in European women.METHODS: In 15 cohorts from nine European countries, individual estimates of air pollution levels at the residence were estimated by standardized land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE) and Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter (TRANSPHORM) projects: particulate matter (PM) ≤2.5μm, ≤10μm, and 2.5–10μm in diameter (PM2.5, PM10, and PMcoarse, respectively); PM2.5 absorbance; nitrogen oxides (NO2 and NOx); traffic intensity; and elemental composition of PM. We estimated cohort-specific associations between breast cancer and air pollutants using Cox regression models, adjusting for major lifestyle risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.RESULTS: Of 74,750 postmenopausal women included in the study, 3,612 developed breast cancer during 991,353 person-years of follow-up. We found positive and statistically insignificant associations between breast cancer and PM2.5 {hazard ratio (HR)=1.08 [95% confidence interval (CI): 0.77, 1.51] per 5 μg/m(3)}, PM10 [1.07 (95% CI: 0.89, 1.30) per 10 μg/m(3)], PMcoarse[1.20 (95% CI: 0.96, 1.49 per 5 μg/m(3)], and NO(2) [1.02 (95% CI: 0.98, 1.07 per 10 μg/m(3)], and a statistically significant association with NOx [1.04 (95% CI: 1.00, 1.08) per 20 μg/m(3), p=0.04].CONCLUSIONS: We found suggestive evidence of an association between ambient air pollution and incidence of postmenopausal breast cancer in European women.
KW - Journal Article
U2 - 10.1289/EHP1742
DO - 10.1289/EHP1742
M3 - Journal article
C2 - 29033383
VL - 125
SP - 1
EP - 14
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 10
M1 - 107005
ER -
ID: 184770308