Long non-coding RNAs as novel players in β cell function and type 1 diabetes

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Long non-coding RNAs as novel players in β cell function and type 1 diabetes. / Mirza, Aashiq H; Kaur, Simranjeet; Pociot, Flemming.

In: Human Genomics (Online), Vol. 11, 17, 24.07.2017.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Mirza, AH, Kaur, S & Pociot, F 2017, 'Long non-coding RNAs as novel players in β cell function and type 1 diabetes', Human Genomics (Online), vol. 11, 17. https://doi.org/10.1186/s40246-017-0113-7

APA

Mirza, A. H., Kaur, S., & Pociot, F. (2017). Long non-coding RNAs as novel players in β cell function and type 1 diabetes. Human Genomics (Online), 11, [17]. https://doi.org/10.1186/s40246-017-0113-7

Vancouver

Mirza AH, Kaur S, Pociot F. Long non-coding RNAs as novel players in β cell function and type 1 diabetes. Human Genomics (Online). 2017 Jul 24;11. 17. https://doi.org/10.1186/s40246-017-0113-7

Author

Mirza, Aashiq H ; Kaur, Simranjeet ; Pociot, Flemming. / Long non-coding RNAs as novel players in β cell function and type 1 diabetes. In: Human Genomics (Online). 2017 ; Vol. 11.

Bibtex

@article{14f607689ea74e64b116f460afe9aee0,
title = "Long non-coding RNAs as novel players in β cell function and type 1 diabetes",
abstract = "BackgroundLong non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D).Main body of abstractThis review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.ConclusionWe accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.",
author = "Mirza, {Aashiq H} and Simranjeet Kaur and Flemming Pociot",
year = "2017",
month = jul,
day = "24",
doi = "10.1186/s40246-017-0113-7",
language = "English",
volume = "11",
journal = "Human Genomics",
issn = "1479-7364",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Long non-coding RNAs as novel players in β cell function and type 1 diabetes

AU - Mirza, Aashiq H

AU - Kaur, Simranjeet

AU - Pociot, Flemming

PY - 2017/7/24

Y1 - 2017/7/24

N2 - BackgroundLong non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D).Main body of abstractThis review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.ConclusionWe accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.

AB - BackgroundLong non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulating body of evidence based on multitude studies has highlighted the role of lncRNAs in many autoimmune and inflammatory diseases, including type 1 diabetes (T1D).Main body of abstractThis review highlights emerging roles of lncRNAs in immune and islet β cell function as well as some of the challenges and opportunities in understanding the pathogenesis of T1D and its complications.ConclusionWe accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.

U2 - 10.1186/s40246-017-0113-7

DO - 10.1186/s40246-017-0113-7

M3 - Review

C2 - 28738846

VL - 11

JO - Human Genomics

JF - Human Genomics

SN - 1479-7364

M1 - 17

ER -

ID: 185066940