Locomotor circuits in the mammalian spinal cord
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Intrinsic spinal networks, known as central pattern generators (CPGs), control the timing and pattern of the muscle activity underlying locomotion in mammals. This review discusses new advances in understanding the mammalian CPGs with a focus on experiments that address the overall network structure as well as the identification of CPG neurons. I address the identification of excitatory CPG neurons and their role in rhythm generation, the organization of flexor-extensor networks, and the diverse role of commissural interneurons in coordinating left-right movements. Molecular and genetic approaches that have the potential to elucidate the function of populations of CPG interneurons are also discussed.
Original language | English |
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Title of host publication | Annual Review of Neuroscience |
Number of pages | 28 |
Publication date | 5 Oct 2006 |
Pages | 279-306 |
ISBN (Print) | 0824324293, 9780824324292 |
DOIs | |
Publication status | Published - 5 Oct 2006 |
Series | Annual Review of Neuroscience |
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Volume | 29 |
ISSN | 0147-006X |
- Interneurons, Molecular genetic, Motor control, Transcription factors, Transgenic mice
Research areas
ID: 194978433