Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Locked nucleic acid : a potent nucleic acid analog in therapeutics and biotechnology. / Stenvang, Jan; Sørensen, Mads D; Wengel, Jesper.

In: Oligonucleotides, Vol. 14, No. 2, 2004, p. 130-46.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stenvang, J, Sørensen, MD & Wengel, J 2004, 'Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology', Oligonucleotides, vol. 14, no. 2, pp. 130-46. https://doi.org/10.1089/1545457041526317

APA

Stenvang, J., Sørensen, M. D., & Wengel, J. (2004). Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology. Oligonucleotides, 14(2), 130-46. https://doi.org/10.1089/1545457041526317

Vancouver

Stenvang J, Sørensen MD, Wengel J. Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology. Oligonucleotides. 2004;14(2):130-46. https://doi.org/10.1089/1545457041526317

Author

Stenvang, Jan ; Sørensen, Mads D ; Wengel, Jesper. / Locked nucleic acid : a potent nucleic acid analog in therapeutics and biotechnology. In: Oligonucleotides. 2004 ; Vol. 14, No. 2. pp. 130-46.

Bibtex

@article{9c731a97e2d6494587858fceab361f7e,
title = "Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology",
abstract = "Locked nucleic acid (LNA) is a class of nucleic acid analogs possessing very high affinity and excellent specificity toward complementary DNA and RNA, and LNA oligonucleotides have been applied as antisense molecules both in vitro and in vivo. In this review, we briefly describe the basic physiochemical properties of LNA and some of the difficulties that may be encountered when applying LNA technology. The central part of the review focuses on the use of LNA molecules in regulation of gene expression, including delivery to cells, stability, unspecific effects, toxicity, pharmacokinetics, and design of LNA oligonucleotides. The last part evaluates LNA as a diagnostic tool in genotyping.",
keywords = "Animals, Biotechnology, Drug Design, Humans, Oligonucleotides, Oligonucleotides, Antisense, Ribonuclease H",
author = "Jan Stenvang and S{\o}rensen, {Mads D} and Jesper Wengel",
year = "2004",
doi = "10.1089/1545457041526317",
language = "English",
volume = "14",
pages = "130--46",
journal = "Nucleic Acid Therapeutics",
issn = "2159-3337",
publisher = "Mary AnnLiebert, Inc. Publishers",
number = "2",

}

RIS

TY - JOUR

T1 - Locked nucleic acid

T2 - a potent nucleic acid analog in therapeutics and biotechnology

AU - Stenvang, Jan

AU - Sørensen, Mads D

AU - Wengel, Jesper

PY - 2004

Y1 - 2004

N2 - Locked nucleic acid (LNA) is a class of nucleic acid analogs possessing very high affinity and excellent specificity toward complementary DNA and RNA, and LNA oligonucleotides have been applied as antisense molecules both in vitro and in vivo. In this review, we briefly describe the basic physiochemical properties of LNA and some of the difficulties that may be encountered when applying LNA technology. The central part of the review focuses on the use of LNA molecules in regulation of gene expression, including delivery to cells, stability, unspecific effects, toxicity, pharmacokinetics, and design of LNA oligonucleotides. The last part evaluates LNA as a diagnostic tool in genotyping.

AB - Locked nucleic acid (LNA) is a class of nucleic acid analogs possessing very high affinity and excellent specificity toward complementary DNA and RNA, and LNA oligonucleotides have been applied as antisense molecules both in vitro and in vivo. In this review, we briefly describe the basic physiochemical properties of LNA and some of the difficulties that may be encountered when applying LNA technology. The central part of the review focuses on the use of LNA molecules in regulation of gene expression, including delivery to cells, stability, unspecific effects, toxicity, pharmacokinetics, and design of LNA oligonucleotides. The last part evaluates LNA as a diagnostic tool in genotyping.

KW - Animals

KW - Biotechnology

KW - Drug Design

KW - Humans

KW - Oligonucleotides

KW - Oligonucleotides, Antisense

KW - Ribonuclease H

U2 - 10.1089/1545457041526317

DO - 10.1089/1545457041526317

M3 - Journal article

C2 - 15294076

VL - 14

SP - 130

EP - 146

JO - Nucleic Acid Therapeutics

JF - Nucleic Acid Therapeutics

SN - 2159-3337

IS - 2

ER -

ID: 59324800