Limited protective effect of the CCR5Delta32/CCR5Delta32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus
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Limited protective effect of the CCR5Delta32/CCR5Delta32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus. / Iversen, Astrid K N; Christiansen, Claus Bohn; Attermann, Jørn; Eugen-Olsen, Jesper; Schulman, Sam; Berntorp, Erik; Ingerslev, Jørgen; Fugger, Lars Henrik; Scheibel, Elma; Tengborn, Lillian; Gerstoft, Jan; Dickmeiss, Ebbe; Svejgaard, Arne; Skinhøj, Peter.
In: Journal of Infectious Diseases, Vol. 187, No. 2, 2003, p. 215-25.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Limited protective effect of the CCR5Delta32/CCR5Delta32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus
AU - Iversen, Astrid K N
AU - Christiansen, Claus Bohn
AU - Attermann, Jørn
AU - Eugen-Olsen, Jesper
AU - Schulman, Sam
AU - Berntorp, Erik
AU - Ingerslev, Jørgen
AU - Fugger, Lars Henrik
AU - Scheibel, Elma
AU - Tengborn, Lillian
AU - Gerstoft, Jan
AU - Dickmeiss, Ebbe
AU - Svejgaard, Arne
AU - Skinhøj, Peter
PY - 2003
Y1 - 2003
N2 - The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in approximately 2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.
AB - The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in approximately 2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.
U2 - http://dx.doi.org/10.1086/345881
DO - http://dx.doi.org/10.1086/345881
M3 - Journal article
VL - 187
SP - 215
EP - 225
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -
ID: 34171463