Ligand binding by PDZ domains
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Ligand binding by PDZ domains. / Chi, Celestine N.; Bach, Anders; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.
In: BioFactors, Vol. 38, No. 5, 2012, p. 338-348 (Review).Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Ligand binding by PDZ domains
AU - Chi, Celestine N.
AU - Bach, Anders
AU - Strømgaard, Kristian
AU - Gianni, Stefano
AU - Jemth, Per
N1 - Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.
PY - 2012
Y1 - 2012
N2 - The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common protein-protein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found in most cell types, but neuronal proteins, for example, are particularly rich in these domains. The general function of PDZ domains is to bring proteins together within the appropriate cellular compartment, thereby facilitating scaffolding, signaling, and trafficking events. The many functions of PDZ domains under normal physiological as well as pathological conditions have been reviewed recently. In this review, we focus on the molecular details of how PDZ domains bind their protein ligands and their potential as drug targets in this context.
AB - The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common protein-protein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found in most cell types, but neuronal proteins, for example, are particularly rich in these domains. The general function of PDZ domains is to bring proteins together within the appropriate cellular compartment, thereby facilitating scaffolding, signaling, and trafficking events. The many functions of PDZ domains under normal physiological as well as pathological conditions have been reviewed recently. In this review, we focus on the molecular details of how PDZ domains bind their protein ligands and their potential as drug targets in this context.
KW - Animals
KW - Binding Sites
KW - Humans
KW - Ligands
KW - Models, Molecular
KW - Nerve Tissue Proteins
KW - Nervous System Diseases
KW - PDZ Domains
KW - Peptidomimetics
KW - Protein Binding
KW - Protein Structure, Secondary
KW - Protein Transport
KW - Signal Transduction
U2 - 10.1002/biof.1031
DO - 10.1002/biof.1031
M3 - Journal article
C2 - 22674855
VL - 38
SP - 338-348 (Review)
JO - BioFactors
JF - BioFactors
SN - 0951-6433
IS - 5
ER -
ID: 45807203