TY - JOUR

T1 - Leptin and bone mineral density

T2 - a cross-sectional study in obese and nonobese men

AU - Morberg, Cathrine M.

AU - Tetens, Inge

AU - Black, Eva

AU - Toubro, Søren

AU - Sørensen, Thorkild I.A.

AU - Pedersen, Oluf Borbye

AU - Astrup, Arne

PY - 2003

Y1 - 2003

N2 - Leptin has been suggested to decrease bone mineral density (BMD). This observational analysis explored the relationship between serum leptin and BMD in 327 nonobese men (controls) (body mass index 26.1 +/- 3.7 kg/m(2), age 49.9 +/- 6.0 yr) and 285 juvenile obese men (body mass index 35.9 +/- 5.9 kg/m(2), age 47.5 +/- 5.1 yr). Whole-body dual-energy x-ray absorptiometry scan measured BMD, fat mass, and lean mass. Fasting serum leptin (nanograms per milliliter) was strongly associated with fat mass (kilograms) in both controls (r = 0.876; P <0.01) and juvenile obese (r = 0.838; P <0.001). An inverse relation between BMD adjusted for body weight and serum leptin emerged in both the control group (r = -0.186; P <0.01) and the juvenile obese group (r = -0.135; P <0.05). In a multiple linear regression, fat mass, lean body mass, and occupational physical activity were positively associated with BMD in the control group, whereas in the juvenile obese, only lean body mass was positively associated with BMD and smoking negatively associated with BMD. Our study supports that leptin is inversely associated with BMD and may play a direct role in the bone metabolism in nonobese and obese Danish males, but it also stresses the fact that the strong covariation between the examined variables is a shortcoming of the cross-sectional design.

AB - Leptin has been suggested to decrease bone mineral density (BMD). This observational analysis explored the relationship between serum leptin and BMD in 327 nonobese men (controls) (body mass index 26.1 +/- 3.7 kg/m(2), age 49.9 +/- 6.0 yr) and 285 juvenile obese men (body mass index 35.9 +/- 5.9 kg/m(2), age 47.5 +/- 5.1 yr). Whole-body dual-energy x-ray absorptiometry scan measured BMD, fat mass, and lean mass. Fasting serum leptin (nanograms per milliliter) was strongly associated with fat mass (kilograms) in both controls (r = 0.876; P <0.01) and juvenile obese (r = 0.838; P <0.001). An inverse relation between BMD adjusted for body weight and serum leptin emerged in both the control group (r = -0.186; P <0.01) and the juvenile obese group (r = -0.135; P <0.05). In a multiple linear regression, fat mass, lean body mass, and occupational physical activity were positively associated with BMD in the control group, whereas in the juvenile obese, only lean body mass was positively associated with BMD and smoking negatively associated with BMD. Our study supports that leptin is inversely associated with BMD and may play a direct role in the bone metabolism in nonobese and obese Danish males, but it also stresses the fact that the strong covariation between the examined variables is a shortcoming of the cross-sectional design.

KW - Adult

KW - Age of Onset

KW - Body Composition

KW - Bone Density

KW - Case-Control Studies

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Humans

KW - Leptin

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Obesity

KW - Physical Exertion

KW - Smoking

U2 - 10.1210/jc.2003-030496

DO - 10.1210/jc.2003-030496

M3 - Journal article

C2 - 14671171

VL - 88

SP - 5795

EP - 5800

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 12

ER -