Length of life gained with surgical treatment of prostate cancer: A population-based analysis
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Length of life gained with surgical treatment of prostate cancer : A population-based analysis. / Røder, Martin Andreas; Brasso, Klaus; Rusch, Ea; Johansen, Jørgen; Langkilde, Niels Christian; Nielsen, Helle Hvarness; Carlsson, Steen; Jakobsen, Henrik; Borre, Michael; Iversen, Peter.
In: Scandinavian Journal of Urology and Nephrology, Vol. 49, No. 4, 2015, p. 275-281.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Length of life gained with surgical treatment of prostate cancer
T2 - A population-based analysis
AU - Røder, Martin Andreas
AU - Brasso, Klaus
AU - Rusch, Ea
AU - Johansen, Jørgen
AU - Langkilde, Niels Christian
AU - Nielsen, Helle Hvarness
AU - Carlsson, Steen
AU - Jakobsen, Henrik
AU - Borre, Michael
AU - Iversen, Peter
PY - 2015
Y1 - 2015
N2 - OBJECTIVE: The aim of this study was to analyse relative survival, excess mortality and gain in life expectancy in men who underwent radical prostatectomy (RP) for localized prostate cancer (PCa) between 1995 and 2011 in Denmark.MATERIAL AND METHODS: The study population comprised the complete cohort of 6489 men who underwent RP between 1995 and 2011. Risk of mortality was calculated using a competing risk model. Relative survival, excess mortality rate (EMR) and gain in life expectancy in men undergoing RP were calculated using a matched cohort Danish population based on date of birth and date of surgery.RESULTS: During follow-up 328 patients died, 109 (33.2%) of PCa and 219 (66.8%) of other causes. The cumulative incidence of PCa mortality was 5.8% [95% confidence interval (CI) 4.4, 7.2] after 10 years. Relative survival was significantly above 1.0 for RP patients, except for high-risk patients. EMR was -9.34 (95% CI -10.56, -8.13) after 10 years, i.e. nine men would die in excess of the general population. Overall, the gain in life expectancy in men undergoing RP compared with the general population was 0.41 years.CONCLUSION: This population-based study demonstrated that the gain in life expectancy with RP compared with the general population in Denmark is minimal.
AB - OBJECTIVE: The aim of this study was to analyse relative survival, excess mortality and gain in life expectancy in men who underwent radical prostatectomy (RP) for localized prostate cancer (PCa) between 1995 and 2011 in Denmark.MATERIAL AND METHODS: The study population comprised the complete cohort of 6489 men who underwent RP between 1995 and 2011. Risk of mortality was calculated using a competing risk model. Relative survival, excess mortality rate (EMR) and gain in life expectancy in men undergoing RP were calculated using a matched cohort Danish population based on date of birth and date of surgery.RESULTS: During follow-up 328 patients died, 109 (33.2%) of PCa and 219 (66.8%) of other causes. The cumulative incidence of PCa mortality was 5.8% [95% confidence interval (CI) 4.4, 7.2] after 10 years. Relative survival was significantly above 1.0 for RP patients, except for high-risk patients. EMR was -9.34 (95% CI -10.56, -8.13) after 10 years, i.e. nine men would die in excess of the general population. Overall, the gain in life expectancy in men undergoing RP compared with the general population was 0.41 years.CONCLUSION: This population-based study demonstrated that the gain in life expectancy with RP compared with the general population in Denmark is minimal.
U2 - 10.3109/21681805.2014.984324
DO - 10.3109/21681805.2014.984324
M3 - Journal article
C2 - 25438988
VL - 49
SP - 275
EP - 281
JO - Scandinavian Journal of Urology
JF - Scandinavian Journal of Urology
SN - 2168-1805
IS - 4
ER -
ID: 156458724