Left atrial volume and function assessed by cardiac magnetic resonance imaging are markers of subclinical atrial fibrillation as detected by continuous monitoring

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Left atrial volume and function assessed by cardiac magnetic resonance imaging are markers of subclinical atrial fibrillation as detected by continuous monitoring. / Bertelsen, Litten; Diederichsen, Søren Zöga; Haugan, Ketil Jørgen; Brandes, Axel; Graff, Claus; Krieger, Derk; Kronborg, Christian; Køber, Lars; Højberg, Søren; Vejlstrup, Niels; Svendsen, Jesper Hastrup.

In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Vol. 22, No. 5, 05.2020, p. 724-731.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bertelsen, L, Diederichsen, SZ, Haugan, KJ, Brandes, A, Graff, C, Krieger, D, Kronborg, C, Køber, L, Højberg, S, Vejlstrup, N & Svendsen, JH 2020, 'Left atrial volume and function assessed by cardiac magnetic resonance imaging are markers of subclinical atrial fibrillation as detected by continuous monitoring', Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 22, no. 5, pp. 724-731. https://doi.org/10.1093/europace/euaa035

APA

Bertelsen, L., Diederichsen, S. Z., Haugan, K. J., Brandes, A., Graff, C., Krieger, D., Kronborg, C., Køber, L., Højberg, S., Vejlstrup, N., & Svendsen, J. H. (2020). Left atrial volume and function assessed by cardiac magnetic resonance imaging are markers of subclinical atrial fibrillation as detected by continuous monitoring. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 22(5), 724-731. https://doi.org/10.1093/europace/euaa035

Vancouver

Bertelsen L, Diederichsen SZ, Haugan KJ, Brandes A, Graff C, Krieger D et al. Left atrial volume and function assessed by cardiac magnetic resonance imaging are markers of subclinical atrial fibrillation as detected by continuous monitoring. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2020 May;22(5):724-731. https://doi.org/10.1093/europace/euaa035

Author

Bertelsen, Litten ; Diederichsen, Søren Zöga ; Haugan, Ketil Jørgen ; Brandes, Axel ; Graff, Claus ; Krieger, Derk ; Kronborg, Christian ; Køber, Lars ; Højberg, Søren ; Vejlstrup, Niels ; Svendsen, Jesper Hastrup. / Left atrial volume and function assessed by cardiac magnetic resonance imaging are markers of subclinical atrial fibrillation as detected by continuous monitoring. In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2020 ; Vol. 22, No. 5. pp. 724-731.

Bibtex

@article{fdfb14e7972e4d4386a9bb8af797239f,

title = "Left atrial volume and function assessed by cardiac magnetic resonance imaging are markers of subclinical atrial fibrillation as detected by continuous monitoring",

abstract = "AIMS: We aimed to investigate whether left atrial (LA) markers from cardiovascular magnetic resonance (CMR) were able to predict atrial fibrillation (AF) in elderly patients with risk factors for stroke. METHODS AND RESULTS: At baseline, 203 participants with stroke risk factors but without history of AF underwent advanced CMR and received an implantable loop recorder. During a median of 40 (37-42) months of continuous monitoring, incident AF was detected in 79 patients (39%). With regards to CMR markers, a steep increase in incidence rate of AF was seen with LA maximum volume (LAmax) above 55 mL/m2, LA minimum volume (LAmin) above 30 mL/m2, LA total emptying fraction (LA TEF) below 45%, LA active emptying fraction (LA AEF) below 37%, LA strain S below 25%, LA strain A below 17%, and LA strain rate A above -1.7 s-1. After multivariate adjustment, the above-mentioned CMR markers remained associated with AF incidence: hazard ratio (95% confidence interval) 1.25 (1.06-1.48) and 1.51 (1.22-1.87) per 10 mL/m2 increase of LAmax and LAmin, respectively, 1.49 (1.26-1.76) and 1.46 CI (1.25-1.71) per 5% decrease in LA TEF and LA AEF, respectively, 1.23 (1.05-1.44) and 1.56 (1.18-2.06) per 5% decrease in LA strain S and A, respectively, and 2.06 (1.31-3.23) per s-1 increase in LA strain rate A. In prediction analyses, LA functional indices increased area under the receiver operating characteristic curve significantly. CONCLUSION: The risk of AF, including asymptomatic AF, increases significantly with increasing LA volumes and worsening LA function.",

keywords = "Atrial fibrillation, Cardiovascular magnetic resonance imaging, Continuous monitoring, Left atrium, Screening, Strain",

author = "Litten Bertelsen and Diederichsen, {S{\o}ren Z{\"o}ga} and Haugan, {Ketil J{\o}rgen} and Axel Brandes and Claus Graff and Derk Krieger and Christian Kronborg and Lars K{\o}ber and S{\o}ren H{\o}jberg and Niels Vejlstrup and Svendsen, {Jesper Hastrup}",

year = "2020",

month = may,

doi = "10.1093/europace/euaa035",

language = "English",

volume = "22",

pages = "724--731",

journal = "Europace",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "5",

}

RIS

TY - JOUR

T1 - Left atrial volume and function assessed by cardiac magnetic resonance imaging are markers of subclinical atrial fibrillation as detected by continuous monitoring

AU - Bertelsen, Litten

AU - Diederichsen, Søren Zöga

AU - Haugan, Ketil Jørgen

AU - Brandes, Axel

AU - Graff, Claus

AU - Krieger, Derk

AU - Kronborg, Christian

AU - Køber, Lars

AU - Højberg, Søren

AU - Vejlstrup, Niels

AU - Svendsen, Jesper Hastrup

PY - 2020/5

Y1 - 2020/5

N2 - AIMS: We aimed to investigate whether left atrial (LA) markers from cardiovascular magnetic resonance (CMR) were able to predict atrial fibrillation (AF) in elderly patients with risk factors for stroke. METHODS AND RESULTS: At baseline, 203 participants with stroke risk factors but without history of AF underwent advanced CMR and received an implantable loop recorder. During a median of 40 (37-42) months of continuous monitoring, incident AF was detected in 79 patients (39%). With regards to CMR markers, a steep increase in incidence rate of AF was seen with LA maximum volume (LAmax) above 55 mL/m2, LA minimum volume (LAmin) above 30 mL/m2, LA total emptying fraction (LA TEF) below 45%, LA active emptying fraction (LA AEF) below 37%, LA strain S below 25%, LA strain A below 17%, and LA strain rate A above -1.7 s-1. After multivariate adjustment, the above-mentioned CMR markers remained associated with AF incidence: hazard ratio (95% confidence interval) 1.25 (1.06-1.48) and 1.51 (1.22-1.87) per 10 mL/m2 increase of LAmax and LAmin, respectively, 1.49 (1.26-1.76) and 1.46 CI (1.25-1.71) per 5% decrease in LA TEF and LA AEF, respectively, 1.23 (1.05-1.44) and 1.56 (1.18-2.06) per 5% decrease in LA strain S and A, respectively, and 2.06 (1.31-3.23) per s-1 increase in LA strain rate A. In prediction analyses, LA functional indices increased area under the receiver operating characteristic curve significantly. CONCLUSION: The risk of AF, including asymptomatic AF, increases significantly with increasing LA volumes and worsening LA function.

AB - AIMS: We aimed to investigate whether left atrial (LA) markers from cardiovascular magnetic resonance (CMR) were able to predict atrial fibrillation (AF) in elderly patients with risk factors for stroke. METHODS AND RESULTS: At baseline, 203 participants with stroke risk factors but without history of AF underwent advanced CMR and received an implantable loop recorder. During a median of 40 (37-42) months of continuous monitoring, incident AF was detected in 79 patients (39%). With regards to CMR markers, a steep increase in incidence rate of AF was seen with LA maximum volume (LAmax) above 55 mL/m2, LA minimum volume (LAmin) above 30 mL/m2, LA total emptying fraction (LA TEF) below 45%, LA active emptying fraction (LA AEF) below 37%, LA strain S below 25%, LA strain A below 17%, and LA strain rate A above -1.7 s-1. After multivariate adjustment, the above-mentioned CMR markers remained associated with AF incidence: hazard ratio (95% confidence interval) 1.25 (1.06-1.48) and 1.51 (1.22-1.87) per 10 mL/m2 increase of LAmax and LAmin, respectively, 1.49 (1.26-1.76) and 1.46 CI (1.25-1.71) per 5% decrease in LA TEF and LA AEF, respectively, 1.23 (1.05-1.44) and 1.56 (1.18-2.06) per 5% decrease in LA strain S and A, respectively, and 2.06 (1.31-3.23) per s-1 increase in LA strain rate A. In prediction analyses, LA functional indices increased area under the receiver operating characteristic curve significantly. CONCLUSION: The risk of AF, including asymptomatic AF, increases significantly with increasing LA volumes and worsening LA function.

KW - Atrial fibrillation

KW - Cardiovascular magnetic resonance imaging

KW - Continuous monitoring

KW - Left atrium

KW - Screening

KW - Strain

U2 - 10.1093/europace/euaa035

DO - 10.1093/europace/euaa035

M3 - Journal article

C2 - 32125356

AN - SCOPUS:85084326971

VL - 22

SP - 724

EP - 731

JO - Europace

JF - Europace

SN - 1099-5129

IS - 5

ER -

ID: 242607346