Lack of tolerance of headache and radial artery diameter during a 7 hour intravenous infusion of nitroglycerin
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Lack of tolerance of headache and radial artery diameter during a 7 hour intravenous infusion of nitroglycerin. / Iversen, Helle Klingenberg; Nielsen, T H; Tfelt-Hansen, P; Olesen, J.
In: European Journal of Clinical Pharmacology, Vol. 44, No. 1, 1993, p. 47-50.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lack of tolerance of headache and radial artery diameter during a 7 hour intravenous infusion of nitroglycerin
AU - Iversen, Helle Klingenberg
AU - Nielsen, T H
AU - Tfelt-Hansen, P
AU - Olesen, J
PY - 1993
Y1 - 1993
N2 - Nitroglycerin-(NTG)-induced headache and dilatation of the radial artery were followed in a double blind, randomized, placebo-controlled, cross-over study in 6 healthy volunteers. NTG 0.5 microgram.kg-1 x min-1 or saline were infused i.v. for 7 h, and subsequently the infusion rate was doubled for 10 min. The radial artery diameter was measured repeatedly with high frequency ultrasound and pain was scored using a 10 point verbal scale. After 5 min of NTG infusion both headache and the arterial diameter differed significantly from baseline, and no further significant change occurred. The intensity of the headache was mild to medium (median headache score 3, range 1-7). The mean dilatation of the radial artery was 36%. The dilatation in each individual, was stable over time, both during NTG and placebo, and it did not change with the double infusion rate. The headache score in each individual was more fluctuant. No tolerance either to the NTG-induced headache or arterial dilatation was observed.
AB - Nitroglycerin-(NTG)-induced headache and dilatation of the radial artery were followed in a double blind, randomized, placebo-controlled, cross-over study in 6 healthy volunteers. NTG 0.5 microgram.kg-1 x min-1 or saline were infused i.v. for 7 h, and subsequently the infusion rate was doubled for 10 min. The radial artery diameter was measured repeatedly with high frequency ultrasound and pain was scored using a 10 point verbal scale. After 5 min of NTG infusion both headache and the arterial diameter differed significantly from baseline, and no further significant change occurred. The intensity of the headache was mild to medium (median headache score 3, range 1-7). The mean dilatation of the radial artery was 36%. The dilatation in each individual, was stable over time, both during NTG and placebo, and it did not change with the double infusion rate. The headache score in each individual was more fluctuant. No tolerance either to the NTG-induced headache or arterial dilatation was observed.
KW - Adult
KW - Double-Blind Method
KW - Female
KW - Headache
KW - Heart Rate
KW - Humans
KW - Infusions, Intravenous
KW - Male
KW - Nitroglycerin
KW - Radial Artery
KW - Vasodilation
M3 - Journal article
C2 - 8436154
VL - 44
SP - 47
EP - 50
JO - European Journal of Clinical Pharmacology
JF - European Journal of Clinical Pharmacology
SN - 0031-6970
IS - 1
ER -
ID: 128984532