Kinetic modeling in PET imaging of hypoxia
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Kinetic modeling in PET imaging of hypoxia. / Li, Fan; Jørgensen, Jesper Tranekjær; Hansen, Anders E; Kjaer, Andreas.
In: American Journal of Nuclear Medicine and Molecular Imaging, Vol. 4, No. 6, 2014, p. 490-506.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Kinetic modeling in PET imaging of hypoxia
AU - Li, Fan
AU - Jørgensen, Jesper Tranekjær
AU - Hansen, Anders E
AU - Kjaer, Andreas
PY - 2014
Y1 - 2014
N2 - Tumor hypoxia is associated with increased therapeutic resistance leading to poor treatment outcome. Therefore the ability to detect and quantify intratumoral oxygenation could play an important role in future individual personalized treatment strategies. Positron Emission Tomography (PET) can be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET contains additional valuable information on the temporal changes in tracer distribution. Kinetic modeling can be used to extract relevant pharmacokinetic parameters of tracer behavior in vivo that reflects relevant physiological processes. In this paper, we review the potential contribution of kinetic analysis for PET imaging of hypoxia.
AB - Tumor hypoxia is associated with increased therapeutic resistance leading to poor treatment outcome. Therefore the ability to detect and quantify intratumoral oxygenation could play an important role in future individual personalized treatment strategies. Positron Emission Tomography (PET) can be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET contains additional valuable information on the temporal changes in tracer distribution. Kinetic modeling can be used to extract relevant pharmacokinetic parameters of tracer behavior in vivo that reflects relevant physiological processes. In this paper, we review the potential contribution of kinetic analysis for PET imaging of hypoxia.
M3 - Journal article
C2 - 25250200
VL - 4
SP - 490
EP - 506
JO - American Journal of Nuclear Medicine and Molecular Imaging
JF - American Journal of Nuclear Medicine and Molecular Imaging
SN - 2160-8407
IS - 6
ER -
ID: 130806162