Iodine fortification may influence the age-related change in thyroid volume: a longitudinal population-based study (DanThyr)
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Iodine fortification may influence the age-related change in thyroid volume : a longitudinal population-based study (DanThyr). / Krejbjerg, Anne; Bjergved, Lena; Pedersen, Inge Bülow; Carlé, Allan; Jørgensen, Torben; Perrild, Hans; Ovesen, Lars; Rasmussen, Lone Banke; Knudsen, Nils; Laurberg, Peter.
In: European Journal of Endocrinology, Vol. 170, No. 4, 04.2014, p. 507-17.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Iodine fortification may influence the age-related change in thyroid volume
T2 - a longitudinal population-based study (DanThyr)
AU - Krejbjerg, Anne
AU - Bjergved, Lena
AU - Pedersen, Inge Bülow
AU - Carlé, Allan
AU - Jørgensen, Torben
AU - Perrild, Hans
AU - Ovesen, Lars
AU - Rasmussen, Lone Banke
AU - Knudsen, Nils
AU - Laurberg, Peter
PY - 2014/4
Y1 - 2014/4
N2 - OBJECTIVE: To assess the individuals' thyroid volume changes after the mandatory nationwide iodine fortification (IF) program in two Danish areas with different iodine intake at baseline (Copenhagen, mild iodine deficiency (ID) and Aalborg, moderate ID).DESIGN: A longitudinal population-based study (DanThyr).METHODS: We examined 2465 adults before (1997) and after (2008) the Danish IF of salt (2000). Ultrasonography was carried out by the same sonographers using the same equipment, after controlling performances. Participants treated for thyroid disease were excluded from analyses.RESULTS: Overall, median thyroid volume had increased in Copenhagen (11.8-12.2 ml, P=0.001) and decreased in Aalborg, although not significantly (13.3-13.1 ml, P=0.07) during the 11 years of follow-up. In both regions, there was an age-related trend in individual changes in thyroid volume from baseline to follow-up; thyroid volume increased in women <40 years of age and decreased in women >40 years of age. IN A MULTIVARIATE REGRESSION MODEL, HIGHER AGE AT ENTRY WAS A PREDICTOR (P0.05) FOR THYROID VOLUME DECREASE 20% DURING THE FOLLOW-UP PERIOD (WOMEN AGED 4045 YEARS: odds ratio (OR) 4.3 (95% CI, 2.2-8.2); women aged 60-65 years: 5.8 (2.9-11.6)) and individuals of higher age were also less likely to have an increase in thyroid volume (women aged 40-45 years: OR 0.2 (0.1-0.3); women aged 60-65: OR 0.3 (0.2-0.4)).CONCLUSIONS: Age-dependent differences in thyroid volume and enlargement had leveled out after the Danish iodization program. Thus, the previously observed increase in thyroid volume with age may have been caused by ID.
AB - OBJECTIVE: To assess the individuals' thyroid volume changes after the mandatory nationwide iodine fortification (IF) program in two Danish areas with different iodine intake at baseline (Copenhagen, mild iodine deficiency (ID) and Aalborg, moderate ID).DESIGN: A longitudinal population-based study (DanThyr).METHODS: We examined 2465 adults before (1997) and after (2008) the Danish IF of salt (2000). Ultrasonography was carried out by the same sonographers using the same equipment, after controlling performances. Participants treated for thyroid disease were excluded from analyses.RESULTS: Overall, median thyroid volume had increased in Copenhagen (11.8-12.2 ml, P=0.001) and decreased in Aalborg, although not significantly (13.3-13.1 ml, P=0.07) during the 11 years of follow-up. In both regions, there was an age-related trend in individual changes in thyroid volume from baseline to follow-up; thyroid volume increased in women <40 years of age and decreased in women >40 years of age. IN A MULTIVARIATE REGRESSION MODEL, HIGHER AGE AT ENTRY WAS A PREDICTOR (P0.05) FOR THYROID VOLUME DECREASE 20% DURING THE FOLLOW-UP PERIOD (WOMEN AGED 4045 YEARS: odds ratio (OR) 4.3 (95% CI, 2.2-8.2); women aged 60-65 years: 5.8 (2.9-11.6)) and individuals of higher age were also less likely to have an increase in thyroid volume (women aged 40-45 years: OR 0.2 (0.1-0.3); women aged 60-65: OR 0.3 (0.2-0.4)).CONCLUSIONS: Age-dependent differences in thyroid volume and enlargement had leveled out after the Danish iodization program. Thus, the previously observed increase in thyroid volume with age may have been caused by ID.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Aged
KW - Cross-Sectional Studies
KW - Denmark
KW - Female
KW - Food, Fortified
KW - Goiter
KW - Humans
KW - Iodine
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Organ Size
KW - Sodium Chloride, Dietary
KW - Thyroid Gland
KW - Young Adult
U2 - 10.1530/EJE-13-0918
DO - 10.1530/EJE-13-0918
M3 - Journal article
C2 - 24399250
VL - 170
SP - 507
EP - 517
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 4
ER -
ID: 138215185