Insulin resistance as a predictor of incident asthma-like symptoms in adults
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Insulin resistance as a predictor of incident asthma-like symptoms in adults. / Thuesen, B H; Husemoen, L L N; Hersoug, L-G; Pisinger, C; Linneberg, A.
In: Clinical and Experimental Allergy, Vol. 39, No. 5, 2009, p. 700-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Insulin resistance as a predictor of incident asthma-like symptoms in adults
AU - Thuesen, B H
AU - Husemoen, L L N
AU - Hersoug, L-G
AU - Pisinger, C
AU - Linneberg, A
N1 - Keywords: Asthma; Body Mass Index; Denmark; Female; Follow-Up Studies; Humans; Incidence; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Questionnaires; Respiratory Sounds; Risk Factors; Sex Factors; Waist Circumference
PY - 2009
Y1 - 2009
N2 - BACKGROUND: There is accumulating evidence that obesity is associated with an increased risk of asthma. It has been hypothesized that insulin resistance may be involved in obesity-induced asthma, but till date there is no prospective data on this issue. OBJECTIVE: To investigate the association of obesity and insulin resistance with the incidence of asthma-like symptoms in adults. METHODS: Out of a random sample of 12 934 persons from a general population, 6784 (52.5%) were included and participated in a health examination in 1999-2001. After 5 years they were re-invited and 4516 (66.6%) participated at follow-up. At baseline three obesity measures were considered: body mass index, waist circumference, and waist-to-hip ratio. In addition, fasting glucose and insulin were measured for determination of insulin resistance. Information on asthma-like symptoms at baseline and follow-up were obtained by questionnaires. A total of 3441 participants defined as non-asthmatic at baseline and with complete information on all the considered variables were included in the analyses. Data were controlled for confounding by sex, age, social status, and smoking. RESULTS: All obesity measures were associated with incident wheezing and asthma-like symptoms. In addition, insulin resistance was associated with incident wheezing [odds ratio (OR) 1.87, 95% confidence interval (CI) 1.38-2.54] and asthma-like symptoms (OR 1.61, 95% CI 1.23-2.10). The effect of insulin resistance was stronger than that of obesity and was independent of sex. CONCLUSION: We found that insulin resistance was associated with an increased risk of developing asthma-like symptoms. This finding supports the hypothesis that obesity and asthma may be linked through inflammatory pathways also involved in insulin resistance.
AB - BACKGROUND: There is accumulating evidence that obesity is associated with an increased risk of asthma. It has been hypothesized that insulin resistance may be involved in obesity-induced asthma, but till date there is no prospective data on this issue. OBJECTIVE: To investigate the association of obesity and insulin resistance with the incidence of asthma-like symptoms in adults. METHODS: Out of a random sample of 12 934 persons from a general population, 6784 (52.5%) were included and participated in a health examination in 1999-2001. After 5 years they were re-invited and 4516 (66.6%) participated at follow-up. At baseline three obesity measures were considered: body mass index, waist circumference, and waist-to-hip ratio. In addition, fasting glucose and insulin were measured for determination of insulin resistance. Information on asthma-like symptoms at baseline and follow-up were obtained by questionnaires. A total of 3441 participants defined as non-asthmatic at baseline and with complete information on all the considered variables were included in the analyses. Data were controlled for confounding by sex, age, social status, and smoking. RESULTS: All obesity measures were associated with incident wheezing and asthma-like symptoms. In addition, insulin resistance was associated with incident wheezing [odds ratio (OR) 1.87, 95% confidence interval (CI) 1.38-2.54] and asthma-like symptoms (OR 1.61, 95% CI 1.23-2.10). The effect of insulin resistance was stronger than that of obesity and was independent of sex. CONCLUSION: We found that insulin resistance was associated with an increased risk of developing asthma-like symptoms. This finding supports the hypothesis that obesity and asthma may be linked through inflammatory pathways also involved in insulin resistance.
U2 - 10.1111/j.1365-2222.2008.03197.x
DO - 10.1111/j.1365-2222.2008.03197.x
M3 - Journal article
C2 - 19260867
VL - 39
SP - 700
EP - 707
JO - Clinical Allergy
JF - Clinical Allergy
SN - 0954-7894
IS - 5
ER -
ID: 21183684