Inflammatory markers in umbilical cord blood from small-for-gestational-age newborns
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Inflammatory markers in umbilical cord blood from small-for-gestational-age newborns. / Lausten-Thomsen, Ulrik; Olsen, Marianne; Greisen, Gorm; Schmiegelow, Kjeld.
In: Fetal and Pediatric Pathology (Print Edition), Vol. 33, No. 2, 04.2014, p. 114-118.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Inflammatory markers in umbilical cord blood from small-for-gestational-age newborns
AU - Lausten-Thomsen, Ulrik
AU - Olsen, Marianne
AU - Greisen, Gorm
AU - Schmiegelow, Kjeld
PY - 2014/4
Y1 - 2014/4
N2 - This study investigates the role of inflammation in intrauterine growth retardation by exploring the levels of inflammatory markers in umbilical cord blood from neonates who were born small-for-gestational-age (SGA) and comparing them to neonates who were born appropriate-for-gestational-age (AGA). Interleukin 6 (IL-6), Tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by standard methods in term or near-term (gestational age >36 weeks) neonates born SGA (n = 45) and a matched group of neonates born AGA (n = 45). Infants exposed to maternal chronic diseases, diabetes or pre-eclampsia were excluded. SGA was defined as two standard derivations below the expected for term and gender. In multivariate regression analyses significant elevation in cord blood concentration of IL-6 was demonstrated in the SGA group (mean 4.56 vs. 2.38, p = 0.002). The results indicate the presence of elevated inflammatory markers in the cord blood from SGA infants compared to AGA infants, and consequently the results suggest an inflammatory component in intrauterine growth restriction (IUGR).
AB - This study investigates the role of inflammation in intrauterine growth retardation by exploring the levels of inflammatory markers in umbilical cord blood from neonates who were born small-for-gestational-age (SGA) and comparing them to neonates who were born appropriate-for-gestational-age (AGA). Interleukin 6 (IL-6), Tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by standard methods in term or near-term (gestational age >36 weeks) neonates born SGA (n = 45) and a matched group of neonates born AGA (n = 45). Infants exposed to maternal chronic diseases, diabetes or pre-eclampsia were excluded. SGA was defined as two standard derivations below the expected for term and gender. In multivariate regression analyses significant elevation in cord blood concentration of IL-6 was demonstrated in the SGA group (mean 4.56 vs. 2.38, p = 0.002). The results indicate the presence of elevated inflammatory markers in the cord blood from SGA infants compared to AGA infants, and consequently the results suggest an inflammatory component in intrauterine growth restriction (IUGR).
KW - Adult
KW - Biological Markers
KW - C-Reactive Protein
KW - Case-Control Studies
KW - Female
KW - Fetal Blood
KW - Fetal Growth Retardation
KW - Humans
KW - Infant, Newborn
KW - Infant, Small for Gestational Age
KW - Inflammation
KW - Inflammation Mediators
KW - Interleukin-6
KW - Male
KW - Pregnancy
KW - Reference Values
KW - Tumor Necrosis Factor-alpha
KW - Young Adult
U2 - 10.3109/15513815.2013.879239
DO - 10.3109/15513815.2013.879239
M3 - Journal article
C2 - 24476425
VL - 33
SP - 114
EP - 118
JO - Fetal and Pediatric Pathology
JF - Fetal and Pediatric Pathology
SN - 1551-3815
IS - 2
ER -
ID: 135495358