Induction of nitrate tolerance is not a useful treatment in cluster headache

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Standard

Induction of nitrate tolerance is not a useful treatment in cluster headache. / Christiansen, I; Iversen, Helle Klingenberg; Olesen, J.

In: Cephalalgia : an international journal of headache, Vol. 20, No. 5, 06.2000, p. 445-54.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christiansen, I, Iversen, HK & Olesen, J 2000, 'Induction of nitrate tolerance is not a useful treatment in cluster headache', Cephalalgia : an international journal of headache, vol. 20, no. 5, pp. 445-54.

APA

Christiansen, I., Iversen, H. K., & Olesen, J. (2000). Induction of nitrate tolerance is not a useful treatment in cluster headache. Cephalalgia : an international journal of headache, 20(5), 445-54.

Vancouver

Christiansen I, Iversen HK, Olesen J. Induction of nitrate tolerance is not a useful treatment in cluster headache. Cephalalgia : an international journal of headache. 2000 Jun;20(5):445-54.

Author

Christiansen, I ; Iversen, Helle Klingenberg ; Olesen, J. / Induction of nitrate tolerance is not a useful treatment in cluster headache. In: Cephalalgia : an international journal of headache. 2000 ; Vol. 20, No. 5. pp. 445-54.

Bibtex

@article{3c17cc9b676e4363879ce13de2e950b6,
title = "Induction of nitrate tolerance is not a useful treatment in cluster headache",
abstract = "UNLABELLED: The aims of the present study were to investigate whether induction of nitrate tolerance is a useful treatment in cluster headache and to correlate any changes in attack frequency of cluster headache and nitrate-induced headache to the vascular adaptation during continuous nitrate administration. The results were compared to results obtained from studies of nitrate tolerance in healthy subjects.MATERIALS AND METHODS: 5-isosorbide-mononitrate (5-ISMN) 30 mg was administered orally three times daily for 4 weeks in nine sufferers of chronic cluster headache in a double-blind, randomized placebo-controlled cross-over design. Blood velocity in the middle cerebral artery was measured with transcranial Doppler and the diameters of the temporal and radial arteries were measured with high frequency ultrasound. The haemodynamic data were compared to changes in the frequency of cluster headache attacks and interval headaches over time.RESULTS: Tolerance was complete within 24 h in the middle cerebral arteries and after 7 days in the symptomatic temporal artery, while tolerance of the radial artery was not observed within this period. The time profiles of tolerance were almost identical to the time profiles observed in healthy subjects. A close temporal association between the disappearance of nitrate-induced headache and tolerance of the temporal artery was observed but tolerance had no effect on cluster headache attack frequency.CONCLUSIONS: Induction of tolerance to nitrates cannot be used to treat cluster headache. If pain is related to arterial dilatation the results point to extracerebral rather than cerebral arteries as the site of nociception. However, other peripheral and central pain-modulating effects of nitric oxide, the time courses of which are unknown, should also be taken into consideration.",
keywords = "Adult, Aged, Blood Flow Velocity, Blood Pressure, Cerebral Arteries, Cluster Headache, Cross-Over Studies, Double-Blind Method, Drug Tolerance, Female, Heart Rate, Humans, Isosorbide Dinitrate, Male, Middle Aged, Radial Artery, Temporal Arteries, Treatment Failure, Vasodilation, Vasodilator Agents",
author = "I Christiansen and Iversen, {Helle Klingenberg} and J Olesen",
year = "2000",
month = jun,
language = "English",
volume = "20",
pages = "445--54",
journal = "Cephalalgia",
issn = "0800-1952",
publisher = "SAGE Publications",
number = "5",

}

RIS

TY - JOUR

T1 - Induction of nitrate tolerance is not a useful treatment in cluster headache

AU - Christiansen, I

AU - Iversen, Helle Klingenberg

AU - Olesen, J

PY - 2000/6

Y1 - 2000/6

N2 - UNLABELLED: The aims of the present study were to investigate whether induction of nitrate tolerance is a useful treatment in cluster headache and to correlate any changes in attack frequency of cluster headache and nitrate-induced headache to the vascular adaptation during continuous nitrate administration. The results were compared to results obtained from studies of nitrate tolerance in healthy subjects.MATERIALS AND METHODS: 5-isosorbide-mononitrate (5-ISMN) 30 mg was administered orally three times daily for 4 weeks in nine sufferers of chronic cluster headache in a double-blind, randomized placebo-controlled cross-over design. Blood velocity in the middle cerebral artery was measured with transcranial Doppler and the diameters of the temporal and radial arteries were measured with high frequency ultrasound. The haemodynamic data were compared to changes in the frequency of cluster headache attacks and interval headaches over time.RESULTS: Tolerance was complete within 24 h in the middle cerebral arteries and after 7 days in the symptomatic temporal artery, while tolerance of the radial artery was not observed within this period. The time profiles of tolerance were almost identical to the time profiles observed in healthy subjects. A close temporal association between the disappearance of nitrate-induced headache and tolerance of the temporal artery was observed but tolerance had no effect on cluster headache attack frequency.CONCLUSIONS: Induction of tolerance to nitrates cannot be used to treat cluster headache. If pain is related to arterial dilatation the results point to extracerebral rather than cerebral arteries as the site of nociception. However, other peripheral and central pain-modulating effects of nitric oxide, the time courses of which are unknown, should also be taken into consideration.

AB - UNLABELLED: The aims of the present study were to investigate whether induction of nitrate tolerance is a useful treatment in cluster headache and to correlate any changes in attack frequency of cluster headache and nitrate-induced headache to the vascular adaptation during continuous nitrate administration. The results were compared to results obtained from studies of nitrate tolerance in healthy subjects.MATERIALS AND METHODS: 5-isosorbide-mononitrate (5-ISMN) 30 mg was administered orally three times daily for 4 weeks in nine sufferers of chronic cluster headache in a double-blind, randomized placebo-controlled cross-over design. Blood velocity in the middle cerebral artery was measured with transcranial Doppler and the diameters of the temporal and radial arteries were measured with high frequency ultrasound. The haemodynamic data were compared to changes in the frequency of cluster headache attacks and interval headaches over time.RESULTS: Tolerance was complete within 24 h in the middle cerebral arteries and after 7 days in the symptomatic temporal artery, while tolerance of the radial artery was not observed within this period. The time profiles of tolerance were almost identical to the time profiles observed in healthy subjects. A close temporal association between the disappearance of nitrate-induced headache and tolerance of the temporal artery was observed but tolerance had no effect on cluster headache attack frequency.CONCLUSIONS: Induction of tolerance to nitrates cannot be used to treat cluster headache. If pain is related to arterial dilatation the results point to extracerebral rather than cerebral arteries as the site of nociception. However, other peripheral and central pain-modulating effects of nitric oxide, the time courses of which are unknown, should also be taken into consideration.

KW - Adult

KW - Aged

KW - Blood Flow Velocity

KW - Blood Pressure

KW - Cerebral Arteries

KW - Cluster Headache

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Drug Tolerance

KW - Female

KW - Heart Rate

KW - Humans

KW - Isosorbide Dinitrate

KW - Male

KW - Middle Aged

KW - Radial Artery

KW - Temporal Arteries

KW - Treatment Failure

KW - Vasodilation

KW - Vasodilator Agents

M3 - Journal article

C2 - 11037740

VL - 20

SP - 445

EP - 454

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 5

ER -

ID: 128983682