Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures. / Skougaard, M.; Stisen, Z. R.; Jørgensen, T S; Egeberg, A.; Hansen, R. L.; Perez-Chada, L. M.; Mogensen, M.; Merola, J. F.; Gerwien, J. G.; Kristensen, L. E.

In: Scandinavian Journal of Rheumatology, Vol. 52, No. 3, 2023, p. 259-267.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skougaard, M, Stisen, ZR, Jørgensen, TS, Egeberg, A, Hansen, RL, Perez-Chada, LM, Mogensen, M, Merola, JF, Gerwien, JG & Kristensen, LE 2023, 'Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures', Scandinavian Journal of Rheumatology, vol. 52, no. 3, pp. 259-267. https://doi.org/10.1080/03009742.2022.2044116

APA

Skougaard, M., Stisen, Z. R., Jørgensen, T. S., Egeberg, A., Hansen, R. L., Perez-Chada, L. M., Mogensen, M., Merola, J. F., Gerwien, J. G., & Kristensen, L. E. (2023). Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures. Scandinavian Journal of Rheumatology, 52(3), 259-267. https://doi.org/10.1080/03009742.2022.2044116

Vancouver

Skougaard M, Stisen ZR, Jørgensen TS, Egeberg A, Hansen RL, Perez-Chada LM et al. Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures. Scandinavian Journal of Rheumatology. 2023;52(3):259-267. https://doi.org/10.1080/03009742.2022.2044116

Author

Skougaard, M. ; Stisen, Z. R. ; Jørgensen, T S ; Egeberg, A. ; Hansen, R. L. ; Perez-Chada, L. M. ; Mogensen, M. ; Merola, J. F. ; Gerwien, J. G. ; Kristensen, L. E. / Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures. In: Scandinavian Journal of Rheumatology. 2023 ; Vol. 52, No. 3. pp. 259-267.

Bibtex

@article{76b9c4d91328414fa505bc6f676d0325,

title = "Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures",

abstract = "Objectives: To examine the prevalence of sleep disturbances, quantified by the Pittsburgh Sleep Quality Index (PSQI), in patients with psoriatic arthritis (PsA), psoriasis (PsO) and healthy controls (HCs), explore associations between PSQI and clinical and patient-reported outcomes, and evaluate the effect of treatment on PSQI. Method: Patients were included from the Parker Institute{\textquoteright}s PsA patient cohort to evaluate the prevalence of sleep disturbances. Univariate and multivariate regression analyses were used to explore associations between sleep disturbance and outcome measures. Treatment effect in PsA patients was assessed with a mixed-effect model for repeated measures. Results: In total, 109 PsA patients, 20 PsO patients, and 20 HCs were included. Sleep disturbances were reported by 66.1% of PsA patients, 45.0% of PsO patients, and 15.0% of HCs. Univariate regression analyses revealed statistically significant associations (p < 0.001) between PSQI and Disease Activity Score (DAS28CRP), tender points, visual analogue scale (VAS) patient global and pain, Psoriatic Arthritis Impact of Disease fatigue, Health Assessment Questionnaire (HAQ), and painDETECT score. Multivariate regression analysis demonstrated VAS patient global, VAS pain, and tender points as being independently associated with PSQI. The mixed-effect model revealed no effect of treatment. Conclusion: More PsA patients than PsO patients and HCs reported sleep disturbances. Sleep disturbances were associated with inflammatory and non-inflammatory measures possibly explaining the limited effect of treatment. This demonstrates the need for interdisciplinary approaches to improve the management of sleep disturbance in PsA. Trial registration: ClinicalTrials.gov (NCT02572700).",

author = "M. Skougaard and Stisen, {Z. R.} and J{\o}rgensen, {T S} and A. Egeberg and Hansen, {R. L.} and Perez-Chada, {L. M.} and M. Mogensen and Merola, {J. F.} and Gerwien, {J. G.} and Kristensen, {L. E.}",

note = "Publisher Copyright: {\textcopyright} 2022 Scandinavian Journal of Rheumatology Foundation.",

year = "2023",

doi = "10.1080/03009742.2022.2044116",

language = "English",

volume = "52",

pages = "259--267",

journal = "Acta rheumatologica Scandinavica",

issn = "0301-3847",

publisher = "Taylor & Francis",

number = "3",

}

RIS

TY - JOUR

T1 - Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures

AU - Skougaard, M.

AU - Stisen, Z. R.

AU - Jørgensen, T S

AU - Egeberg, A.

AU - Hansen, R. L.

AU - Perez-Chada, L. M.

AU - Mogensen, M.

AU - Merola, J. F.

AU - Gerwien, J. G.

AU - Kristensen, L. E.

PY - 2023

Y1 - 2023

N2 - Objectives: To examine the prevalence of sleep disturbances, quantified by the Pittsburgh Sleep Quality Index (PSQI), in patients with psoriatic arthritis (PsA), psoriasis (PsO) and healthy controls (HCs), explore associations between PSQI and clinical and patient-reported outcomes, and evaluate the effect of treatment on PSQI. Method: Patients were included from the Parker Institute’s PsA patient cohort to evaluate the prevalence of sleep disturbances. Univariate and multivariate regression analyses were used to explore associations between sleep disturbance and outcome measures. Treatment effect in PsA patients was assessed with a mixed-effect model for repeated measures. Results: In total, 109 PsA patients, 20 PsO patients, and 20 HCs were included. Sleep disturbances were reported by 66.1% of PsA patients, 45.0% of PsO patients, and 15.0% of HCs. Univariate regression analyses revealed statistically significant associations (p < 0.001) between PSQI and Disease Activity Score (DAS28CRP), tender points, visual analogue scale (VAS) patient global and pain, Psoriatic Arthritis Impact of Disease fatigue, Health Assessment Questionnaire (HAQ), and painDETECT score. Multivariate regression analysis demonstrated VAS patient global, VAS pain, and tender points as being independently associated with PSQI. The mixed-effect model revealed no effect of treatment. Conclusion: More PsA patients than PsO patients and HCs reported sleep disturbances. Sleep disturbances were associated with inflammatory and non-inflammatory measures possibly explaining the limited effect of treatment. This demonstrates the need for interdisciplinary approaches to improve the management of sleep disturbance in PsA. Trial registration: ClinicalTrials.gov (NCT02572700).

AB - Objectives: To examine the prevalence of sleep disturbances, quantified by the Pittsburgh Sleep Quality Index (PSQI), in patients with psoriatic arthritis (PsA), psoriasis (PsO) and healthy controls (HCs), explore associations between PSQI and clinical and patient-reported outcomes, and evaluate the effect of treatment on PSQI. Method: Patients were included from the Parker Institute’s PsA patient cohort to evaluate the prevalence of sleep disturbances. Univariate and multivariate regression analyses were used to explore associations between sleep disturbance and outcome measures. Treatment effect in PsA patients was assessed with a mixed-effect model for repeated measures. Results: In total, 109 PsA patients, 20 PsO patients, and 20 HCs were included. Sleep disturbances were reported by 66.1% of PsA patients, 45.0% of PsO patients, and 15.0% of HCs. Univariate regression analyses revealed statistically significant associations (p < 0.001) between PSQI and Disease Activity Score (DAS28CRP), tender points, visual analogue scale (VAS) patient global and pain, Psoriatic Arthritis Impact of Disease fatigue, Health Assessment Questionnaire (HAQ), and painDETECT score. Multivariate regression analysis demonstrated VAS patient global, VAS pain, and tender points as being independently associated with PSQI. The mixed-effect model revealed no effect of treatment. Conclusion: More PsA patients than PsO patients and HCs reported sleep disturbances. Sleep disturbances were associated with inflammatory and non-inflammatory measures possibly explaining the limited effect of treatment. This demonstrates the need for interdisciplinary approaches to improve the management of sleep disturbance in PsA. Trial registration: ClinicalTrials.gov (NCT02572700).

U2 - 10.1080/03009742.2022.2044116

DO - 10.1080/03009742.2022.2044116

M3 - Journal article

C2 - 35302402

AN - SCOPUS:85126821244

VL - 52

SP - 259

EP - 267

JO - Acta rheumatologica Scandinavica

JF - Acta rheumatologica Scandinavica

SN - 0301-3847

IS - 3

ER -

ID: 313433029