Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings
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Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings. / Viste, Rannveig; Follin, Louise F.; Kornum, Birgitte R.; Lie, Benedicte A.; Viken, Marte K.; Thorsby, Per M.; Rootwelt, Terje; Christensen, Julie A. E.; Knudsen-Heier, Stine.
In: Sleep, Vol. 46, No. 3, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings
AU - Viste, Rannveig
AU - Follin, Louise F.
AU - Kornum, Birgitte R.
AU - Lie, Benedicte A.
AU - Viken, Marte K.
AU - Thorsby, Per M.
AU - Rootwelt, Terje
AU - Christensen, Julie A. E.
AU - Knudsen-Heier, Stine
PY - 2023
Y1 - 2023
N2 - Study Objectives Narcolepsy type 1 (NT1) is characterized by unstable sleep-wake and muscle tonus regulation during sleep. We characterized dream enactment and muscle activity during sleep in a cohort of post-H1N1 NT1 patients and their siblings, and analyzed whether clinical phenotypic characteristics and major risk factors are associated with increased muscle activity. Methods RBD symptoms and polysomnography m. tibialis anterior electromyographical signals [long (0.5-15 s); short (0.1-0.49 s)] were compared between 114 post-H1N1 NT1 patients and 89 non-narcoleptic siblings. Association sub-analyses with RBD symptoms, narcoleptic symptoms, CSF hypocretin-1 levels, and major risk factors [H1N1-(Pandemrix)-vaccination, HLA-DQB1*06:02-positivity] were performed. Results RBD symptoms, REM and NREM long muscle activity indices and REM short muscle activity index were significantly higher in NT1 patients than siblings (all p < 0.001). Patients with undetectable CSF hypocretin-1 levels (
AB - Study Objectives Narcolepsy type 1 (NT1) is characterized by unstable sleep-wake and muscle tonus regulation during sleep. We characterized dream enactment and muscle activity during sleep in a cohort of post-H1N1 NT1 patients and their siblings, and analyzed whether clinical phenotypic characteristics and major risk factors are associated with increased muscle activity. Methods RBD symptoms and polysomnography m. tibialis anterior electromyographical signals [long (0.5-15 s); short (0.1-0.49 s)] were compared between 114 post-H1N1 NT1 patients and 89 non-narcoleptic siblings. Association sub-analyses with RBD symptoms, narcoleptic symptoms, CSF hypocretin-1 levels, and major risk factors [H1N1-(Pandemrix)-vaccination, HLA-DQB1*06:02-positivity] were performed. Results RBD symptoms, REM and NREM long muscle activity indices and REM short muscle activity index were significantly higher in NT1 patients than siblings (all p < 0.001). Patients with undetectable CSF hypocretin-1 levels (
KW - Narcolepsy type 1
KW - NT1
KW - post Pandemrix NT1
KW - muscle activity in sleep
KW - leg movements in sleep
KW - periodic leg movements
KW - dream enactment
KW - REM sleep behavior disorder
KW - CSF hypocretin-1 deficiency
KW - disease continuum in first-degree relatives
KW - RESTLESS LEGS SYNDROME
KW - CSF HYPOCRETIN-1 LEVELS
KW - REM-SLEEP
KW - POST-H1N1 VACCINATION
KW - CHILDHOOD NARCOLEPSY
KW - NORWEGIAN CHILDREN
KW - H1N1 INFLUENZA
KW - T-CELLS
KW - MOVEMENTS
KW - DIAGNOSIS
U2 - 10.1093/sleep/zsac316
DO - 10.1093/sleep/zsac316
M3 - Journal article
C2 - 36562330
VL - 46
JO - Sleep (Online)
JF - Sleep (Online)
SN - 0161-8105
IS - 3
ER -
ID: 335955894