Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model
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Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model. / Lee Hong, S.; Longo, Kenneth A.; Gosney, Elahu; Kopchick, John J.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 69 A, No. 3, 17.03.2014, p. 274-281.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased metabolic flexibility and complexity in a long-lived growth hormone insensitive mouse model
AU - Lee Hong, S.
AU - Longo, Kenneth A.
AU - Gosney, Elahu
AU - Kopchick, John J.
PY - 2014/3/17
Y1 - 2014/3/17
N2 - The goal of this study was to test whether the "loss of the complexity" hypothesis can be applied to compare the metabolic patterns of mouse models with known differences in metabolic and endocrine function as well as life span. Here, we compare the complexity of locomotor activity and metabolic patterns (energy expenditure, VO2, and respiratory quotient) of the long-lived growth hormone receptor gene deleted mice (GHR -/-) and their wild-type littermates. Using approximate entropy as a measure of complexity, we observed greater metabolic complexity, as indicated by greater irregularity in the physiological fluctuations of the GHR-/- mice. Further analysis of the data also revealed lower energy costs of locomotor activity and a stronger relationship between locomotor activity and respiratory quotient in the GHR-/- mice relative to controls. These findings suggest underlying differences in metabolic modulation in the GHR -/- mice revealed especially through measures of complexity of their time-dependent fluctuations.
AB - The goal of this study was to test whether the "loss of the complexity" hypothesis can be applied to compare the metabolic patterns of mouse models with known differences in metabolic and endocrine function as well as life span. Here, we compare the complexity of locomotor activity and metabolic patterns (energy expenditure, VO2, and respiratory quotient) of the long-lived growth hormone receptor gene deleted mice (GHR -/-) and their wild-type littermates. Using approximate entropy as a measure of complexity, we observed greater metabolic complexity, as indicated by greater irregularity in the physiological fluctuations of the GHR-/- mice. Further analysis of the data also revealed lower energy costs of locomotor activity and a stronger relationship between locomotor activity and respiratory quotient in the GHR-/- mice relative to controls. These findings suggest underlying differences in metabolic modulation in the GHR -/- mice revealed especially through measures of complexity of their time-dependent fluctuations.
KW - Animal model
KW - Growth hormone
KW - Longevity
KW - Metabolism
UR - http://www.scopus.com/inward/record.url?scp=84896747719&partnerID=8YFLogxK
U2 - 10.1093/gerona/glt090
DO - 10.1093/gerona/glt090
M3 - Journal article
C2 - 23788654
AN - SCOPUS:84896747719
VL - 69 A
SP - 274
EP - 281
JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
SN - 1079-5006
IS - 3
ER -
ID: 202371314