Increased dopaminergic activity in socially isolated rats: an electrophysiological study

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Increased dopaminergic activity in socially isolated rats: an electrophysiological study. / Fabricius, Katrine; Helboe, Lone; Fink-Jensen, Anders; Wörtwein, Gitta; Steiniger-Brach, Björn; Sotty, Florence; Fabricius, Katrine; Helboe, Lone; Fink-Jensen, Anders; Wörtwein, Gitta; Steiniger-Brach, Björn; Sotty, Florence.

In: Neuroscience Letters, Vol. 482, No. 2, 27.09.2010, p. 117-22.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fabricius, K, Helboe, L, Fink-Jensen, A, Wörtwein, G, Steiniger-Brach, B, Sotty, F, Fabricius, K, Helboe, L, Fink-Jensen, A, Wörtwein, G, Steiniger-Brach, B & Sotty, F 2010, 'Increased dopaminergic activity in socially isolated rats: an electrophysiological study', Neuroscience Letters, vol. 482, no. 2, pp. 117-22. https://doi.org/10.1016/j.neulet.2010.07.014, https://doi.org/10.1016/j.neulet.2010.07.014

APA

Fabricius, K., Helboe, L., Fink-Jensen, A., Wörtwein, G., Steiniger-Brach, B., Sotty, F., Fabricius, K., Helboe, L., Fink-Jensen, A., Wörtwein, G., Steiniger-Brach, B., & Sotty, F. (2010). Increased dopaminergic activity in socially isolated rats: an electrophysiological study. Neuroscience Letters, 482(2), 117-22. https://doi.org/10.1016/j.neulet.2010.07.014, https://doi.org/10.1016/j.neulet.2010.07.014

Vancouver

Fabricius K, Helboe L, Fink-Jensen A, Wörtwein G, Steiniger-Brach B, Sotty F et al. Increased dopaminergic activity in socially isolated rats: an electrophysiological study. Neuroscience Letters. 2010 Sep 27;482(2):117-22. https://doi.org/10.1016/j.neulet.2010.07.014, https://doi.org/10.1016/j.neulet.2010.07.014

Author

Fabricius, Katrine ; Helboe, Lone ; Fink-Jensen, Anders ; Wörtwein, Gitta ; Steiniger-Brach, Björn ; Sotty, Florence ; Fabricius, Katrine ; Helboe, Lone ; Fink-Jensen, Anders ; Wörtwein, Gitta ; Steiniger-Brach, Björn ; Sotty, Florence. / Increased dopaminergic activity in socially isolated rats: an electrophysiological study. In: Neuroscience Letters. 2010 ; Vol. 482, No. 2. pp. 117-22.

Bibtex

@article{c968d930b66811df825b000ea68e967b,

title = "Increased dopaminergic activity in socially isolated rats: an electrophysiological study",

abstract = "The development of animal models mimicking symptoms associated with schizophrenia has been a critical step in understanding the neurobiological mechanisms underlying the disease. Long-term social isolation from weaning in rodents, a model based on the neurodevelopmental hypothesis of schizophrenia, has been suggested to mimic some of the deficits seen in schizophrenic patients. We confirm in the present study that socially isolated rats display an increase in both spontaneous and d-amphetamine-induced locomotor activity, as well as deficits in sensorimotor gating as assessed in a pre-pulse inhibition paradigm. In addition, in vivo electrophysiological studies revealed changes in dopaminergic cell firing activity in the ventral tegmental area of isolated rats when compared to group-housed controls. These alterations include an increase in the number of spontaneously active dopaminergic neurons, and a change of firing activity towards a more irregular and bursting firing pattern. Taken together, our findings suggest that the behavioral phenotype induced by social isolation may be driven by an overactive dopamine system.",

author = "Katrine Fabricius and Lone Helboe and Anders Fink-Jensen and Gitta W{\"o}rtwein and Bj{\"o}rn Steiniger-Brach and Florence Sotty and Katrine Fabricius and Lone Helboe and Anders Fink-Jensen and Gitta W{\"o}rtwein and Bj{\"o}rn Steiniger-Brach and Florence Sotty",

year = "2010",

month = sep,

day = "27",

doi = "10.1016/j.neulet.2010.07.014",

language = "English",

volume = "482",

pages = "117--22",

journal = "Neuroscience letters. Supplement",

issn = "0167-6253",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

RIS

TY - JOUR

T1 - Increased dopaminergic activity in socially isolated rats: an electrophysiological study

AU - Fabricius, Katrine

AU - Helboe, Lone

AU - Fink-Jensen, Anders

AU - Wörtwein, Gitta

AU - Steiniger-Brach, Björn

AU - Sotty, Florence

AU - Fabricius, Katrine

AU - Helboe, Lone

AU - Fink-Jensen, Anders

AU - Wörtwein, Gitta

AU - Steiniger-Brach, Björn

AU - Sotty, Florence

PY - 2010/9/27

Y1 - 2010/9/27

N2 - The development of animal models mimicking symptoms associated with schizophrenia has been a critical step in understanding the neurobiological mechanisms underlying the disease. Long-term social isolation from weaning in rodents, a model based on the neurodevelopmental hypothesis of schizophrenia, has been suggested to mimic some of the deficits seen in schizophrenic patients. We confirm in the present study that socially isolated rats display an increase in both spontaneous and d-amphetamine-induced locomotor activity, as well as deficits in sensorimotor gating as assessed in a pre-pulse inhibition paradigm. In addition, in vivo electrophysiological studies revealed changes in dopaminergic cell firing activity in the ventral tegmental area of isolated rats when compared to group-housed controls. These alterations include an increase in the number of spontaneously active dopaminergic neurons, and a change of firing activity towards a more irregular and bursting firing pattern. Taken together, our findings suggest that the behavioral phenotype induced by social isolation may be driven by an overactive dopamine system.

AB - The development of animal models mimicking symptoms associated with schizophrenia has been a critical step in understanding the neurobiological mechanisms underlying the disease. Long-term social isolation from weaning in rodents, a model based on the neurodevelopmental hypothesis of schizophrenia, has been suggested to mimic some of the deficits seen in schizophrenic patients. We confirm in the present study that socially isolated rats display an increase in both spontaneous and d-amphetamine-induced locomotor activity, as well as deficits in sensorimotor gating as assessed in a pre-pulse inhibition paradigm. In addition, in vivo electrophysiological studies revealed changes in dopaminergic cell firing activity in the ventral tegmental area of isolated rats when compared to group-housed controls. These alterations include an increase in the number of spontaneously active dopaminergic neurons, and a change of firing activity towards a more irregular and bursting firing pattern. Taken together, our findings suggest that the behavioral phenotype induced by social isolation may be driven by an overactive dopamine system.

U2 - 10.1016/j.neulet.2010.07.014

DO - 10.1016/j.neulet.2010.07.014

M3 - Journal article

C2 - 20637831

VL - 482

SP - 117

EP - 122

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

IS - 2

ER -

ID: 21748432