Increased all-cause mortality in concomitant atopic dermatitis and asthma: A nationwide registry-based study

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Increased all-cause mortality in concomitant atopic dermatitis and asthma : A nationwide registry-based study. / Ali, Zarqa; Ulrik, Charlotte Suppli; Egeberg, Alexander; Thyssen, Jacob Pontoppidan; Francis Thomsen, Simon.

In: Clinical and Experimental Allergy, Vol. 51, No. 9, 2021, p. 1207-1217.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ali, Z, Ulrik, CS, Egeberg, A, Thyssen, JP & Francis Thomsen, S 2021, 'Increased all-cause mortality in concomitant atopic dermatitis and asthma: A nationwide registry-based study', Clinical and Experimental Allergy, vol. 51, no. 9, pp. 1207-1217. https://doi.org/10.1111/cea.13978

APA

Ali, Z., Ulrik, C. S., Egeberg, A., Thyssen, J. P., & Francis Thomsen, S. (2021). Increased all-cause mortality in concomitant atopic dermatitis and asthma: A nationwide registry-based study. Clinical and Experimental Allergy, 51(9), 1207-1217. https://doi.org/10.1111/cea.13978

Vancouver

Ali Z, Ulrik CS, Egeberg A, Thyssen JP, Francis Thomsen S. Increased all-cause mortality in concomitant atopic dermatitis and asthma: A nationwide registry-based study. Clinical and Experimental Allergy. 2021;51(9):1207-1217. https://doi.org/10.1111/cea.13978

Author

Ali, Zarqa ; Ulrik, Charlotte Suppli ; Egeberg, Alexander ; Thyssen, Jacob Pontoppidan ; Francis Thomsen, Simon. / Increased all-cause mortality in concomitant atopic dermatitis and asthma : A nationwide registry-based study. In: Clinical and Experimental Allergy. 2021 ; Vol. 51, No. 9. pp. 1207-1217.

Bibtex

@article{3ace7540ae4a4da1b36211488b50caee,
title = "Increased all-cause mortality in concomitant atopic dermatitis and asthma: A nationwide registry-based study",
abstract = "Background Excess mortality has been reported for adults with atopic dermatitis (AD) and asthma. Objective To assess the mortality rate in adults with concomitant AD and asthma. Methods Adults with hospital-diagnosed AD were matched (1:4) with non-AD individuals from the background population. Results The study cohort comprised 8,095 adults with AD (of which 1,201 (14.8%) had concomitant asthma) and 32,380 reference individuals without AD from the background population (of which 878 (2.7%) had asthma). A total of 1,057, 330, 55 and 99 deaths were observed among subjects with neither AD nor asthma, AD only, asthma only, and subjects with concomitant AD and asthma, respectively. The mortality rate per 1,000 person-years was 4.75 (95% CI 4.47-5.05) for subjects with neither AD nor asthma, 7.17 (95% CI 5.92-10.05) for asthma only, 7.09 (95% CI 6.37-7.90) for AD only and 10.87 (95% CI 8.92-13.23) for concomitant AD and asthma. Risk for all-cause mortality was increased in subjects with concomitant AD and asthma compared to asthma only (HR 1.52, 95% CI 1.07-2.15) and neither AD nor asthma (HR 2.27, 95% CI 1.83-2.81) but not compared to subjects with AD only (HR 1.10, 95% CI 0.87-1.39). However, compared to AD only subjects with AD and asthma had increased risk of death due to pulmonary disease (HR 1.81, 95% CI 1.04-3.15). Conclusion Adults with AD, asthma or both conditions have increased risk of death, and further concomitant AD and asthma have increased risk of death compared with asthma alone.",
keywords = "asthma, atopic dermatitis, eczema, mortality, 1,075 OUTPATIENTS, SEX-DIFFERENCES, DISEASE, POPULATION, ADULTS, RISK",
author = "Zarqa Ali and Ulrik, {Charlotte Suppli} and Alexander Egeberg and Thyssen, {Jacob Pontoppidan} and {Francis Thomsen}, Simon",
year = "2021",
doi = "10.1111/cea.13978",
language = "English",
volume = "51",
pages = "1207--1217",
journal = "Clinical and Experimental Allergy",
issn = "0954-7894",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Increased all-cause mortality in concomitant atopic dermatitis and asthma

T2 - A nationwide registry-based study

AU - Ali, Zarqa

AU - Ulrik, Charlotte Suppli

AU - Egeberg, Alexander

AU - Thyssen, Jacob Pontoppidan

AU - Francis Thomsen, Simon

PY - 2021

Y1 - 2021

N2 - Background Excess mortality has been reported for adults with atopic dermatitis (AD) and asthma. Objective To assess the mortality rate in adults with concomitant AD and asthma. Methods Adults with hospital-diagnosed AD were matched (1:4) with non-AD individuals from the background population. Results The study cohort comprised 8,095 adults with AD (of which 1,201 (14.8%) had concomitant asthma) and 32,380 reference individuals without AD from the background population (of which 878 (2.7%) had asthma). A total of 1,057, 330, 55 and 99 deaths were observed among subjects with neither AD nor asthma, AD only, asthma only, and subjects with concomitant AD and asthma, respectively. The mortality rate per 1,000 person-years was 4.75 (95% CI 4.47-5.05) for subjects with neither AD nor asthma, 7.17 (95% CI 5.92-10.05) for asthma only, 7.09 (95% CI 6.37-7.90) for AD only and 10.87 (95% CI 8.92-13.23) for concomitant AD and asthma. Risk for all-cause mortality was increased in subjects with concomitant AD and asthma compared to asthma only (HR 1.52, 95% CI 1.07-2.15) and neither AD nor asthma (HR 2.27, 95% CI 1.83-2.81) but not compared to subjects with AD only (HR 1.10, 95% CI 0.87-1.39). However, compared to AD only subjects with AD and asthma had increased risk of death due to pulmonary disease (HR 1.81, 95% CI 1.04-3.15). Conclusion Adults with AD, asthma or both conditions have increased risk of death, and further concomitant AD and asthma have increased risk of death compared with asthma alone.

AB - Background Excess mortality has been reported for adults with atopic dermatitis (AD) and asthma. Objective To assess the mortality rate in adults with concomitant AD and asthma. Methods Adults with hospital-diagnosed AD were matched (1:4) with non-AD individuals from the background population. Results The study cohort comprised 8,095 adults with AD (of which 1,201 (14.8%) had concomitant asthma) and 32,380 reference individuals without AD from the background population (of which 878 (2.7%) had asthma). A total of 1,057, 330, 55 and 99 deaths were observed among subjects with neither AD nor asthma, AD only, asthma only, and subjects with concomitant AD and asthma, respectively. The mortality rate per 1,000 person-years was 4.75 (95% CI 4.47-5.05) for subjects with neither AD nor asthma, 7.17 (95% CI 5.92-10.05) for asthma only, 7.09 (95% CI 6.37-7.90) for AD only and 10.87 (95% CI 8.92-13.23) for concomitant AD and asthma. Risk for all-cause mortality was increased in subjects with concomitant AD and asthma compared to asthma only (HR 1.52, 95% CI 1.07-2.15) and neither AD nor asthma (HR 2.27, 95% CI 1.83-2.81) but not compared to subjects with AD only (HR 1.10, 95% CI 0.87-1.39). However, compared to AD only subjects with AD and asthma had increased risk of death due to pulmonary disease (HR 1.81, 95% CI 1.04-3.15). Conclusion Adults with AD, asthma or both conditions have increased risk of death, and further concomitant AD and asthma have increased risk of death compared with asthma alone.

KW - asthma

KW - atopic dermatitis

KW - eczema

KW - mortality

KW - 1,075 OUTPATIENTS

KW - SEX-DIFFERENCES

KW - DISEASE

KW - POPULATION

KW - ADULTS

KW - RISK

U2 - 10.1111/cea.13978

DO - 10.1111/cea.13978

M3 - Journal article

C2 - 34191378

VL - 51

SP - 1207

EP - 1217

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

IS - 9

ER -

ID: 274429103