Incidence, treatment, and survival trends in older versus younger women with epithelial ovarian cancer from 2005 to 2018: A nationwide Danish study

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Incidence, treatment, and survival trends in older versus younger women with epithelial ovarian cancer from 2005 to 2018 : A nationwide Danish study. / Ekmann-Gade, Anne Weng; Høgdall, Claus Kim; Seibæk, Lene; Noer, Mette Calundann; Fagö-Olsen, Carsten Lindberg; Schnack, Tine Henrichsen.

In: Gynecologic Oncology, Vol. 164, No. 1, 2022, p. 120-128.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ekmann-Gade, AW, Høgdall, CK, Seibæk, L, Noer, MC, Fagö-Olsen, CL & Schnack, TH 2022, 'Incidence, treatment, and survival trends in older versus younger women with epithelial ovarian cancer from 2005 to 2018: A nationwide Danish study', Gynecologic Oncology, vol. 164, no. 1, pp. 120-128. https://doi.org/10.1016/j.ygyno.2021.10.081

APA

Ekmann-Gade, A. W., Høgdall, C. K., Seibæk, L., Noer, M. C., Fagö-Olsen, C. L., & Schnack, T. H. (2022). Incidence, treatment, and survival trends in older versus younger women with epithelial ovarian cancer from 2005 to 2018: A nationwide Danish study. Gynecologic Oncology, 164(1), 120-128. https://doi.org/10.1016/j.ygyno.2021.10.081

Vancouver

Ekmann-Gade AW, Høgdall CK, Seibæk L, Noer MC, Fagö-Olsen CL, Schnack TH. Incidence, treatment, and survival trends in older versus younger women with epithelial ovarian cancer from 2005 to 2018: A nationwide Danish study. Gynecologic Oncology. 2022;164(1):120-128. https://doi.org/10.1016/j.ygyno.2021.10.081

Author

Ekmann-Gade, Anne Weng ; Høgdall, Claus Kim ; Seibæk, Lene ; Noer, Mette Calundann ; Fagö-Olsen, Carsten Lindberg ; Schnack, Tine Henrichsen. / Incidence, treatment, and survival trends in older versus younger women with epithelial ovarian cancer from 2005 to 2018 : A nationwide Danish study. In: Gynecologic Oncology. 2022 ; Vol. 164, No. 1. pp. 120-128.

Bibtex

@article{e94f9df3af29471d91368b67f6df2b7f,
title = "Incidence, treatment, and survival trends in older versus younger women with epithelial ovarian cancer from 2005 to 2018: A nationwide Danish study",
abstract = "Objective: To examine clinical trends in Denmark for younger and older epithelial ovarian cancer (EOC) patients, focusing on incidence, treatment, and survival changes. Methods: We included a nationwide cohort diagnosed with EOC from 2005 to 2018. We described age-standardized incidence, surgical patterns, residual disease trends, and cancer-specific survival stratified by age (<70 and ≥ 70 years), stage, and period (2005–09, 2010–13, 2014–18). Results: We included 7522 patients. The incidence decreased from 16.3 (2005) to 11.4 (2018) per 100,000 woman-years, driven by the younger cohort. While the proportion of patients with stage IIIC-IV disease undergoing primary debulking surgery (PDS) decreased, the proportion of patients having interval debulking surgery (IDS) and no debulking surgery increased significantly. In 2014–18, 36% and 24% had PDS for younger and older patients, respectively, compared to 72% and 62% in 2005–09. In both age cohorts, the proportion of patients debulked to no residual disease increased significantly among patients with stage IIIC-IV and in the total cohort. Two-year cancer-specific survival increased from 75% (2005–09) to 84% (2014–18) for younger patients and from 53% to 66% for older patients. After adjusting for potential confounders, age ≥ 70 was associated with a 1.4-fold increased risk of cancer-specific death (95% confidence interval: 1.2,1.5). Conclusions: The proportion of patients with advanced EOC not undergoing PDS or IDS increased significantly. During the same period, patients debulked to no residual disease, and cancer-specific survival increased. However, a survival gap in favor of the younger patients remains after adjusting for potential confounders.",
keywords = "Epithelial ovarian cancer, Frailty, Geriatric oncology, Incidence, Interval debulking surgery, Older adults, Primary debulking surgery, Survival",
author = "Ekmann-Gade, {Anne Weng} and H{\o}gdall, {Claus Kim} and Lene Seib{\ae}k and Noer, {Mette Calundann} and Fag{\"o}-Olsen, {Carsten Lindberg} and Schnack, {Tine Henrichsen}",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2022",
doi = "10.1016/j.ygyno.2021.10.081",
language = "English",
volume = "164",
pages = "120--128",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press",
number = "1",

}

RIS

TY - JOUR

T1 - Incidence, treatment, and survival trends in older versus younger women with epithelial ovarian cancer from 2005 to 2018

T2 - A nationwide Danish study

AU - Ekmann-Gade, Anne Weng

AU - Høgdall, Claus Kim

AU - Seibæk, Lene

AU - Noer, Mette Calundann

AU - Fagö-Olsen, Carsten Lindberg

AU - Schnack, Tine Henrichsen

N1 - Publisher Copyright: © 2021 The Authors

PY - 2022

Y1 - 2022

N2 - Objective: To examine clinical trends in Denmark for younger and older epithelial ovarian cancer (EOC) patients, focusing on incidence, treatment, and survival changes. Methods: We included a nationwide cohort diagnosed with EOC from 2005 to 2018. We described age-standardized incidence, surgical patterns, residual disease trends, and cancer-specific survival stratified by age (<70 and ≥ 70 years), stage, and period (2005–09, 2010–13, 2014–18). Results: We included 7522 patients. The incidence decreased from 16.3 (2005) to 11.4 (2018) per 100,000 woman-years, driven by the younger cohort. While the proportion of patients with stage IIIC-IV disease undergoing primary debulking surgery (PDS) decreased, the proportion of patients having interval debulking surgery (IDS) and no debulking surgery increased significantly. In 2014–18, 36% and 24% had PDS for younger and older patients, respectively, compared to 72% and 62% in 2005–09. In both age cohorts, the proportion of patients debulked to no residual disease increased significantly among patients with stage IIIC-IV and in the total cohort. Two-year cancer-specific survival increased from 75% (2005–09) to 84% (2014–18) for younger patients and from 53% to 66% for older patients. After adjusting for potential confounders, age ≥ 70 was associated with a 1.4-fold increased risk of cancer-specific death (95% confidence interval: 1.2,1.5). Conclusions: The proportion of patients with advanced EOC not undergoing PDS or IDS increased significantly. During the same period, patients debulked to no residual disease, and cancer-specific survival increased. However, a survival gap in favor of the younger patients remains after adjusting for potential confounders.

AB - Objective: To examine clinical trends in Denmark for younger and older epithelial ovarian cancer (EOC) patients, focusing on incidence, treatment, and survival changes. Methods: We included a nationwide cohort diagnosed with EOC from 2005 to 2018. We described age-standardized incidence, surgical patterns, residual disease trends, and cancer-specific survival stratified by age (<70 and ≥ 70 years), stage, and period (2005–09, 2010–13, 2014–18). Results: We included 7522 patients. The incidence decreased from 16.3 (2005) to 11.4 (2018) per 100,000 woman-years, driven by the younger cohort. While the proportion of patients with stage IIIC-IV disease undergoing primary debulking surgery (PDS) decreased, the proportion of patients having interval debulking surgery (IDS) and no debulking surgery increased significantly. In 2014–18, 36% and 24% had PDS for younger and older patients, respectively, compared to 72% and 62% in 2005–09. In both age cohorts, the proportion of patients debulked to no residual disease increased significantly among patients with stage IIIC-IV and in the total cohort. Two-year cancer-specific survival increased from 75% (2005–09) to 84% (2014–18) for younger patients and from 53% to 66% for older patients. After adjusting for potential confounders, age ≥ 70 was associated with a 1.4-fold increased risk of cancer-specific death (95% confidence interval: 1.2,1.5). Conclusions: The proportion of patients with advanced EOC not undergoing PDS or IDS increased significantly. During the same period, patients debulked to no residual disease, and cancer-specific survival increased. However, a survival gap in favor of the younger patients remains after adjusting for potential confounders.

KW - Epithelial ovarian cancer

KW - Frailty

KW - Geriatric oncology

KW - Incidence

KW - Interval debulking surgery

KW - Older adults

KW - Primary debulking surgery

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85117951317&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2021.10.081

DO - 10.1016/j.ygyno.2021.10.081

M3 - Journal article

C2 - 34716025

AN - SCOPUS:85117951317

VL - 164

SP - 120

EP - 128

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 1

ER -

ID: 319115663