In situ formed suspensions for local sustained action of celecoxib following intra-articular administration
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In situ formed suspensions for local sustained action of celecoxib following intra-articular administration. / Larsen, Susan Weng; Frost, Anna Buus; Østergaard, Jesper; Jacobsen, Stine; Thomsen, Maj Halling; Lindegaard, Casper; Andersen, Pia Haubro; Larsen, Claus Selch.
2009. Poster session presented at 36th Annual Meeting & Exposition of the Controlled Release Society, Copenhagen, Denmark.Research output: Contribution to conference › Poster › Research
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T1 - In situ formed suspensions for local sustained action of celecoxib following intra-articular administration
AU - Larsen, Susan Weng
AU - Frost, Anna Buus
AU - Østergaard, Jesper
AU - Jacobsen, Stine
AU - Thomsen, Maj Halling
AU - Lindegaard, Casper
AU - Andersen, Pia Haubro
AU - Larsen, Claus Selch
N1 - Conference code: 36
PY - 2009
Y1 - 2009
N2 - In vitro release of celecoxib from in situ formed suspensions intended for intra-articular (IA) delivery has been investigated using a rotating dialysis cell model. The appearance of celecoxib in the acceptor phase after instillation of a concentrated drug solution in PEG 400 into the small aqueous donor compartment was followed by reverse phase HPLC. After an initial fast release a constant flux was observed. Likewise, a similar constant flux was found for a preformed aqueous suspension of the drug. The highly comparable fluxes observed indicate that the solid celecoxib precipitated from the in situ formed suspension exhibited an aqueous solubility similar to that of parent celecoxib used for the preformed aqueous suspension. Results from the in vivo experiments in horses revealed that solid materials as observed within the synovium of the radiocarpal joint 10 days after IA administration of an in situ formed suspension of celecoxib. In the field of IA drug administration the in situ suspension forming drug delivery principle appears promising for the provision of local prolonged drug action. However, for clinical use the reproducibility of the precipitation step in the biological matrix may still need improvement.
AB - In vitro release of celecoxib from in situ formed suspensions intended for intra-articular (IA) delivery has been investigated using a rotating dialysis cell model. The appearance of celecoxib in the acceptor phase after instillation of a concentrated drug solution in PEG 400 into the small aqueous donor compartment was followed by reverse phase HPLC. After an initial fast release a constant flux was observed. Likewise, a similar constant flux was found for a preformed aqueous suspension of the drug. The highly comparable fluxes observed indicate that the solid celecoxib precipitated from the in situ formed suspension exhibited an aqueous solubility similar to that of parent celecoxib used for the preformed aqueous suspension. Results from the in vivo experiments in horses revealed that solid materials as observed within the synovium of the radiocarpal joint 10 days after IA administration of an in situ formed suspension of celecoxib. In the field of IA drug administration the in situ suspension forming drug delivery principle appears promising for the provision of local prolonged drug action. However, for clinical use the reproducibility of the precipitation step in the biological matrix may still need improvement.
M3 - Poster
Y2 - 18 July 2009 through 22 July 2009
ER -
ID: 13999462