Implementation of a vaccination clinic for adult solid organ transplant candidates: A single-center experience
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Implementation of a vaccination clinic for adult solid organ transplant candidates : A single-center experience. / Harboe, Zitta Barrella; Hald, Annemette; Ekenberg, Christina; Ete Wareham, Neval; Fogt Lundbo, Lene; Holler, Jon Gitz; Qvist, Tavs; Rask Hamm, Sebastian; Bjerrum, Stephanie; Rezahosseini, Omid; Suno Krohn, Paul; Gustafsson, Finn; Perch, Michael; Rasmussen, Allan; Dam Nielsen, Susanne.
In: Vaccine, Vol. 41, No. 45, 2023, p. 6637-6644.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Implementation of a vaccination clinic for adult solid organ transplant candidates
T2 - A single-center experience
AU - Harboe, Zitta Barrella
AU - Hald, Annemette
AU - Ekenberg, Christina
AU - Ete Wareham, Neval
AU - Fogt Lundbo, Lene
AU - Holler, Jon Gitz
AU - Qvist, Tavs
AU - Rask Hamm, Sebastian
AU - Bjerrum, Stephanie
AU - Rezahosseini, Omid
AU - Suno Krohn, Paul
AU - Gustafsson, Finn
AU - Perch, Michael
AU - Rasmussen, Allan
AU - Dam Nielsen, Susanne
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Vaccination is an evidence-based strategy to prevent or reduce the severity of infectious diseases (ID). Here, we aimed to describe the experience of implementing a vaccination clinic specifically targeting liver, heart, lung, and combined dual organ transplantation at a single transplantation center in Denmark. In this cohort of 242 solid organ transplant (SOT) candidates, we investigated seroprotection and the proportion of recommended vaccinations documented before transplantation. Furthermore, we registered completed vaccinations after ID consultations. The median age in our cohort was 53 years (IQR, 42–60), 60% were males (n = 135), and liver transplants (n = 138; 57%) were the most frequently planned organ transplants. Before the consultation to the vaccination clinic, influenza and pneumococcal vaccines had the highest proportion of documented vaccination (58% and 37%, respectively). Serological protection was more frequently observed for measles, mumps, or rubella (MMR, approximately 90% for each), while only 30% (n = 72) of SOT candidates showed seroprotection against pneumococcal disease. All SOT candidates required at least one of the recommended vaccines, and over 90% required three or more. At least 10% of patients in our cohort needed a live attenuated vaccine for either MMR or yellow fever. The most frequently administered vaccine was the tetanus–diphtheria-acelullar pertussis (Tdap) booster (n = 217; 90%), influenza vaccination was either administered (n = 16; 7%) or recommended (n = 226; 93%), PCV13 was administered (n = 155; 64%) or recommended (n = 27; 11%), and PPSV23 was either administered (n = 18; 7.4%) or recommended (n = 140; 58%). All SOT candidates adhered completely to their vaccination schedules. Based on our findings, we recommend prioritizing vaccination before transplantation by providing ID consultations for SOT candidates.
AB - Vaccination is an evidence-based strategy to prevent or reduce the severity of infectious diseases (ID). Here, we aimed to describe the experience of implementing a vaccination clinic specifically targeting liver, heart, lung, and combined dual organ transplantation at a single transplantation center in Denmark. In this cohort of 242 solid organ transplant (SOT) candidates, we investigated seroprotection and the proportion of recommended vaccinations documented before transplantation. Furthermore, we registered completed vaccinations after ID consultations. The median age in our cohort was 53 years (IQR, 42–60), 60% were males (n = 135), and liver transplants (n = 138; 57%) were the most frequently planned organ transplants. Before the consultation to the vaccination clinic, influenza and pneumococcal vaccines had the highest proportion of documented vaccination (58% and 37%, respectively). Serological protection was more frequently observed for measles, mumps, or rubella (MMR, approximately 90% for each), while only 30% (n = 72) of SOT candidates showed seroprotection against pneumococcal disease. All SOT candidates required at least one of the recommended vaccines, and over 90% required three or more. At least 10% of patients in our cohort needed a live attenuated vaccine for either MMR or yellow fever. The most frequently administered vaccine was the tetanus–diphtheria-acelullar pertussis (Tdap) booster (n = 217; 90%), influenza vaccination was either administered (n = 16; 7%) or recommended (n = 226; 93%), PCV13 was administered (n = 155; 64%) or recommended (n = 27; 11%), and PPSV23 was either administered (n = 18; 7.4%) or recommended (n = 140; 58%). All SOT candidates adhered completely to their vaccination schedules. Based on our findings, we recommend prioritizing vaccination before transplantation by providing ID consultations for SOT candidates.
U2 - 10.1016/j.vaccine.2023.09.036
DO - 10.1016/j.vaccine.2023.09.036
M3 - Journal article
C2 - 37775467
AN - SCOPUS:85173835742
VL - 41
SP - 6637
EP - 6644
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 45
ER -
ID: 379045326