Impact of non-pharmacological interventions targeting sleep disturbances or disorders in patients with inflammatory arthritis: A systematic review and meta-analysis of randomized trials
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Impact of non-pharmacological interventions targeting sleep disturbances or disorders in patients with inflammatory arthritis : A systematic review and meta-analysis of randomized trials. / Latocha, Kristine M.; Løppenthin, Katrine B.; Al-Bazy, Safa; Albrechtsen, Tannie L.; Jensen, Helle E.; Østergaard, Mikkel; Jennum, Poul J.; Esbensen, Bente A.; Christensen, Robin.
In: Arthritis Care & Research, Vol. 74, No. 12, 2022, p. 2108-2118.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of non-pharmacological interventions targeting sleep disturbances or disorders in patients with inflammatory arthritis
T2 - A systematic review and meta-analysis of randomized trials
AU - Latocha, Kristine M.
AU - Løppenthin, Katrine B.
AU - Al-Bazy, Safa
AU - Albrechtsen, Tannie L.
AU - Jensen, Helle E.
AU - Østergaard, Mikkel
AU - Jennum, Poul J.
AU - Esbensen, Bente A.
AU - Christensen, Robin
PY - 2022
Y1 - 2022
N2 - ObjectivesPatients with inflammatory arthritis (IA) have a high risk of sleep disturbances and disorders. The objective was to evaluate the evidence of non-pharmacological interventions targeting sleep disturbances or disorders in patients with IA.MethodsA systematic search was undertaken from inception to September 8th, 2020. We included randomized trials concerning non-pharmacological interventions applied in adults with IA and concomitant sleep disturbances or disorders. Primary outcome was the sleep domain while secondary outcomes were core outcome domains for IA trials and harms. The Cochrane Risk of Bias tool was applied, and the overall quality of the evidence was assessed using GRADE. Effect sizes for continuous outcomes were based on the standardized mean difference, combined using random-effects meta-analysis.ResultsSix trials (308 patients) were included in the quantitative synthesis; three of these reported improvement in sleep in favor of the non-pharmacological intervention(s). The meta-analysis of the sleep domains indicated a large clinical effect of -0.80 (95% CI, -1.33 to -0.28) in favor of non-pharmacological interventions targeting sleep disturbances or disorders. The estimate was rated down twice for risk of bias, and unexplained inconsistency; this was assessed as corresponding to low quality evidence. None of the secondary core outcomes used in contemporary IA trials indicated clinical benefit in favor of non-pharmacological interventions targeting sleep.ConclusionNon-pharmacological interventions targeting sleep disturbances/disorders in patients with IA indicated a promising effect on sleep outcomes, but not yet with convincing evidence.
AB - ObjectivesPatients with inflammatory arthritis (IA) have a high risk of sleep disturbances and disorders. The objective was to evaluate the evidence of non-pharmacological interventions targeting sleep disturbances or disorders in patients with IA.MethodsA systematic search was undertaken from inception to September 8th, 2020. We included randomized trials concerning non-pharmacological interventions applied in adults with IA and concomitant sleep disturbances or disorders. Primary outcome was the sleep domain while secondary outcomes were core outcome domains for IA trials and harms. The Cochrane Risk of Bias tool was applied, and the overall quality of the evidence was assessed using GRADE. Effect sizes for continuous outcomes were based on the standardized mean difference, combined using random-effects meta-analysis.ResultsSix trials (308 patients) were included in the quantitative synthesis; three of these reported improvement in sleep in favor of the non-pharmacological intervention(s). The meta-analysis of the sleep domains indicated a large clinical effect of -0.80 (95% CI, -1.33 to -0.28) in favor of non-pharmacological interventions targeting sleep disturbances or disorders. The estimate was rated down twice for risk of bias, and unexplained inconsistency; this was assessed as corresponding to low quality evidence. None of the secondary core outcomes used in contemporary IA trials indicated clinical benefit in favor of non-pharmacological interventions targeting sleep.ConclusionNon-pharmacological interventions targeting sleep disturbances/disorders in patients with IA indicated a promising effect on sleep outcomes, but not yet with convincing evidence.
U2 - 10.1002/acr.24731
DO - 10.1002/acr.24731
M3 - Journal article
C2 - 34121362
VL - 74
SP - 2108
EP - 2118
JO - Arthritis Care & Research
JF - Arthritis Care & Research
SN - 2151-464X
IS - 12
ER -
ID: 276647662