Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Impact of high-intensity interval training on cardiac structure and function after COVID-19 : an investigator-blinded randomized controlled trial. / Rasmussen, Iben Elmerdahl; Løk, Mathilde; Durrer, Cody Garett; Foged, Frederik; Schelde, Vera Graungaard; Budde, Josephine Bjørn; Rasmussen, Rasmus Syberg; Høvighoff, Emma Fredskild; Rasmussen, Villads; Lyngbæk, Mark; Jønck, Simon; Krogh-Madsen, Rikke; Lindegaard, Birgitte; Jørgensen, Peter Godsk; Køber, Lars; Vejlstrup, Niels; Klarlund Pedersen, Bente; Ried-Larsen, Mathias; Lund, Morten Asp Vonsild; Christensen, Regitse Højgaard; Berg, Ronan M G.

In: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 135, No. 2, 2023, p. s239-488.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rasmussen, IE, Løk, M, Durrer, CG, Foged, F, Schelde, VG, Budde, JB, Rasmussen, RS, Høvighoff, EF, Rasmussen, V, Lyngbæk, M, Jønck, S, Krogh-Madsen, R, Lindegaard, B, Jørgensen, PG, Køber, L, Vejlstrup, N, Klarlund Pedersen, B, Ried-Larsen, M, Lund, MAV, Christensen, RH & Berg, RMG 2023, 'Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial', Journal of applied physiology (Bethesda, Md. : 1985), vol. 135, no. 2, pp. s239-488. https://doi.org/10.1152/japplphysiol.00078.2023

APA

Rasmussen, I. E., Løk, M., Durrer, C. G., Foged, F., Schelde, V. G., Budde, J. B., Rasmussen, R. S., Høvighoff, E. F., Rasmussen, V., Lyngbæk, M., Jønck, S., Krogh-Madsen, R., Lindegaard, B., Jørgensen, P. G., Køber, L., Vejlstrup, N., Klarlund Pedersen, B., Ried-Larsen, M., Lund, M. A. V., ... Berg, R. M. G. (2023). Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial. Journal of applied physiology (Bethesda, Md. : 1985), 135(2), s239-488. https://doi.org/10.1152/japplphysiol.00078.2023

Vancouver

Rasmussen IE, Løk M, Durrer CG, Foged F, Schelde VG, Budde JB et al. Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial. Journal of applied physiology (Bethesda, Md. : 1985). 2023;135(2):s239-488. https://doi.org/10.1152/japplphysiol.00078.2023

Author

Rasmussen, Iben Elmerdahl ; Løk, Mathilde ; Durrer, Cody Garett ; Foged, Frederik ; Schelde, Vera Graungaard ; Budde, Josephine Bjørn ; Rasmussen, Rasmus Syberg ; Høvighoff, Emma Fredskild ; Rasmussen, Villads ; Lyngbæk, Mark ; Jønck, Simon ; Krogh-Madsen, Rikke ; Lindegaard, Birgitte ; Jørgensen, Peter Godsk ; Køber, Lars ; Vejlstrup, Niels ; Klarlund Pedersen, Bente ; Ried-Larsen, Mathias ; Lund, Morten Asp Vonsild ; Christensen, Regitse Højgaard ; Berg, Ronan M G. / Impact of high-intensity interval training on cardiac structure and function after COVID-19 : an investigator-blinded randomized controlled trial. In: Journal of applied physiology (Bethesda, Md. : 1985). 2023 ; Vol. 135, No. 2. pp. s239-488.

Bibtex

@article{7a6107e8c63f4047a0b9d7db15e05746,
title = "Impact of high-intensity interval training on cardiac structure and function after COVID-19: an investigator-blinded randomized controlled trial",
abstract = "A large proportion of patients suffer from a persistent reduction in cardiorespiratory fitness after recovery from COVID-19, of which the effects on the heart may potentially be reversed through the effect of high-intensity interval training (HIIT). In the present study, we hypothesized that HIIT would increase left ventricular mass (LVM) and improve functional status and health-related quality of life (HRQoL) in individuals previously hospitalized for COVID-19. In this investigator-blinded, randomized controlled trial, 12 weeks of supervised HIIT (4x4 minutes, three times a week) was compared to standard care (control) in individuals recently discharged from hospital due to COVID-19. LVM was assessed by cardiac magnetic resonance imaging (cMRI, primary outcome), while the pulmonary diffusing capacity (DLCOc, secondary outcome) was examined by the single-breath method. Functional status and HRQoL was assessed by Post-COVID-19 Functional Scale (PCFS) and King's brief interstitial lung disease (KBILD) questionnaire, respectively. A total of 28 participants were included (age 57±10, 9 females; HIIT: 58±11, 4 females; standard care: 57±9, 5 females), LVM increased in the HIIT vs. standard care group with a between-group difference of 6.8 [mean, 95%CI: 0.8; 12.8] g; p=0.029. There were no between-group differences in DLCOc or any other lung function metric, which gradually resolved in both groups. Desriptively, PCFS suggested fewer functional limitations in the HIIT group. KBILD improved similarly in the two groups. HIIT is an efficacious exercise intervention for increasing LVM in individuals previously hospitalized for COVID-19.",
author = "Rasmussen, {Iben Elmerdahl} and Mathilde L{\o}k and Durrer, {Cody Garett} and Frederik Foged and Schelde, {Vera Graungaard} and Budde, {Josephine Bj{\o}rn} and Rasmussen, {Rasmus Syberg} and H{\o}vighoff, {Emma Fredskild} and Villads Rasmussen and Mark Lyngb{\ae}k and Simon J{\o}nck and Rikke Krogh-Madsen and Birgitte Lindegaard and J{\o}rgensen, {Peter Godsk} and Lars K{\o}ber and Niels Vejlstrup and {Klarlund Pedersen}, Bente and Mathias Ried-Larsen and Lund, {Morten Asp Vonsild} and Christensen, {Regitse H{\o}jgaard} and Berg, {Ronan M G}",
year = "2023",
doi = "10.1152/japplphysiol.00078.2023",
language = "English",
volume = "135",
pages = "s239--488",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Impact of high-intensity interval training on cardiac structure and function after COVID-19

T2 - an investigator-blinded randomized controlled trial

AU - Rasmussen, Iben Elmerdahl

AU - Løk, Mathilde

AU - Durrer, Cody Garett

AU - Foged, Frederik

AU - Schelde, Vera Graungaard

AU - Budde, Josephine Bjørn

AU - Rasmussen, Rasmus Syberg

AU - Høvighoff, Emma Fredskild

AU - Rasmussen, Villads

AU - Lyngbæk, Mark

AU - Jønck, Simon

AU - Krogh-Madsen, Rikke

AU - Lindegaard, Birgitte

AU - Jørgensen, Peter Godsk

AU - Køber, Lars

AU - Vejlstrup, Niels

AU - Klarlund Pedersen, Bente

AU - Ried-Larsen, Mathias

AU - Lund, Morten Asp Vonsild

AU - Christensen, Regitse Højgaard

AU - Berg, Ronan M G

PY - 2023

Y1 - 2023

N2 - A large proportion of patients suffer from a persistent reduction in cardiorespiratory fitness after recovery from COVID-19, of which the effects on the heart may potentially be reversed through the effect of high-intensity interval training (HIIT). In the present study, we hypothesized that HIIT would increase left ventricular mass (LVM) and improve functional status and health-related quality of life (HRQoL) in individuals previously hospitalized for COVID-19. In this investigator-blinded, randomized controlled trial, 12 weeks of supervised HIIT (4x4 minutes, three times a week) was compared to standard care (control) in individuals recently discharged from hospital due to COVID-19. LVM was assessed by cardiac magnetic resonance imaging (cMRI, primary outcome), while the pulmonary diffusing capacity (DLCOc, secondary outcome) was examined by the single-breath method. Functional status and HRQoL was assessed by Post-COVID-19 Functional Scale (PCFS) and King's brief interstitial lung disease (KBILD) questionnaire, respectively. A total of 28 participants were included (age 57±10, 9 females; HIIT: 58±11, 4 females; standard care: 57±9, 5 females), LVM increased in the HIIT vs. standard care group with a between-group difference of 6.8 [mean, 95%CI: 0.8; 12.8] g; p=0.029. There were no between-group differences in DLCOc or any other lung function metric, which gradually resolved in both groups. Desriptively, PCFS suggested fewer functional limitations in the HIIT group. KBILD improved similarly in the two groups. HIIT is an efficacious exercise intervention for increasing LVM in individuals previously hospitalized for COVID-19.

AB - A large proportion of patients suffer from a persistent reduction in cardiorespiratory fitness after recovery from COVID-19, of which the effects on the heart may potentially be reversed through the effect of high-intensity interval training (HIIT). In the present study, we hypothesized that HIIT would increase left ventricular mass (LVM) and improve functional status and health-related quality of life (HRQoL) in individuals previously hospitalized for COVID-19. In this investigator-blinded, randomized controlled trial, 12 weeks of supervised HIIT (4x4 minutes, three times a week) was compared to standard care (control) in individuals recently discharged from hospital due to COVID-19. LVM was assessed by cardiac magnetic resonance imaging (cMRI, primary outcome), while the pulmonary diffusing capacity (DLCOc, secondary outcome) was examined by the single-breath method. Functional status and HRQoL was assessed by Post-COVID-19 Functional Scale (PCFS) and King's brief interstitial lung disease (KBILD) questionnaire, respectively. A total of 28 participants were included (age 57±10, 9 females; HIIT: 58±11, 4 females; standard care: 57±9, 5 females), LVM increased in the HIIT vs. standard care group with a between-group difference of 6.8 [mean, 95%CI: 0.8; 12.8] g; p=0.029. There were no between-group differences in DLCOc or any other lung function metric, which gradually resolved in both groups. Desriptively, PCFS suggested fewer functional limitations in the HIIT group. KBILD improved similarly in the two groups. HIIT is an efficacious exercise intervention for increasing LVM in individuals previously hospitalized for COVID-19.

U2 - 10.1152/japplphysiol.00078.2023

DO - 10.1152/japplphysiol.00078.2023

M3 - Journal article

C2 - 37391888

VL - 135

SP - s239-488

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -

ID: 360609375