Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model
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Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model. / Chakera, A H; Nielsen, B S; Madsen, J; Romer, J; Kristjansen, P E G; Buch, I; Binderup, Tina; Ingvar, C; Nalla, A; Kjaer, A; Hesse, B; Chakera, A H; Nielsen, Boye S.; Madsen, J; Rømer, John; Kristjansen, Paul Ejnar Gremaud; Buch, I; Binderup, T; Ingvar, C; Nalla, Amarnadh; Kjær, Andreas; Hesse, B.
In: International Journal of Molecular Imaging, Vol. 2011, 2011, p. 828151.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Immunolymphoscintigraphy for metastatic sentinel nodes: test of a model
AU - Chakera, A H
AU - Nielsen, B S
AU - Madsen, J
AU - Romer, J
AU - Kristjansen, P E G
AU - Buch, I
AU - Binderup, Tina
AU - Ingvar, C
AU - Nalla, A
AU - Kjaer, A
AU - Hesse, B
AU - Chakera, A H
AU - Nielsen, Boye S.
AU - Madsen, J
AU - Rømer, John
AU - Kristjansen, Paul Ejnar Gremaud
AU - Buch, I
AU - Binderup, T
AU - Ingvar, C
AU - Nalla, Amarnadh
AU - Kjær, Andreas
AU - Hesse, B
PY - 2011
Y1 - 2011
N2 - Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.
AB - Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune-deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.
U2 - 10.1155/2011/828151
DO - 10.1155/2011/828151
M3 - Journal article
VL - 2011
SP - 828151
JO - International Journal of Molecular Imaging
JF - International Journal of Molecular Imaging
SN - 2090-1712
ER -
ID: 33790867