Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis. / Hooper, Sean D; Boué, Stephanie; Krause, Roland; Jensen, Lars J; Mason, Christopher E; Ghanim, Murad; White, Kevin P; Furlong, Eileen E M; Bork, Peer.
In: Molecular Systems Biology, Vol. 3, 2007, p. 72.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
AU - Hooper, Sean D
AU - Boué, Stephanie
AU - Krause, Roland
AU - Jensen, Lars J
AU - Mason, Christopher E
AU - Ghanim, Murad
AU - White, Kevin P
AU - Furlong, Eileen E M
AU - Bork, Peer
PY - 2007
Y1 - 2007
N2 - Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. By applying conservative filtering criteria and requiring 'sharp' transcript changes, we identified 1534 maternal genes, 792 transient zygotic genes, and 1053 genes whose transcript levels increase during embryogenesis. Each of these three categories is dominated by groups of genes where all transcript levels increase and/or decrease at similar times, suggesting a common mode of regulation. For example, 34% of the transiently expressed genes fall into three groups, with increased transcript levels between 2.5-12, 11-20, and 15-20 h of development, respectively. We highlight common and distinctive functional features of these expression groups and identify a coupling between downregulation of transcript levels and targeted protein degradation. By mapping the groups to the protein network, we also predict and experimentally confirm new functional associations.
AB - Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. By applying conservative filtering criteria and requiring 'sharp' transcript changes, we identified 1534 maternal genes, 792 transient zygotic genes, and 1053 genes whose transcript levels increase during embryogenesis. Each of these three categories is dominated by groups of genes where all transcript levels increase and/or decrease at similar times, suggesting a common mode of regulation. For example, 34% of the transiently expressed genes fall into three groups, with increased transcript levels between 2.5-12, 11-20, and 15-20 h of development, respectively. We highlight common and distinctive functional features of these expression groups and identify a coupling between downregulation of transcript levels and targeted protein degradation. By mapping the groups to the protein network, we also predict and experimentally confirm new functional associations.
U2 - 10.1038/msb4100112
DO - 10.1038/msb4100112
M3 - Journal article
C2 - 17224916
VL - 3
SP - 72
JO - Molecular Systems Biology
JF - Molecular Systems Biology
SN - 1744-4292
ER -
ID: 40749121