Identification and analysis of evolutionarily cohesive functional modules in protein networks

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Identification and analysis of evolutionarily cohesive functional modules in protein networks. / Campillos, Mónica; von Mering, Christian; Jensen, Lars Juhl; Bork, Peer.

In: Genome Research, Vol. 16, No. 3, 2006, p. 374-82.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Campillos, M, von Mering, C, Jensen, LJ & Bork, P 2006, 'Identification and analysis of evolutionarily cohesive functional modules in protein networks', Genome Research, vol. 16, no. 3, pp. 374-82. https://doi.org/10.1101/gr.4336406

APA

Campillos, M., von Mering, C., Jensen, L. J., & Bork, P. (2006). Identification and analysis of evolutionarily cohesive functional modules in protein networks. Genome Research, 16(3), 374-82. https://doi.org/10.1101/gr.4336406

Vancouver

Campillos M, von Mering C, Jensen LJ, Bork P. Identification and analysis of evolutionarily cohesive functional modules in protein networks. Genome Research. 2006;16(3):374-82. https://doi.org/10.1101/gr.4336406

Author

Campillos, Mónica ; von Mering, Christian ; Jensen, Lars Juhl ; Bork, Peer. / Identification and analysis of evolutionarily cohesive functional modules in protein networks. In: Genome Research. 2006 ; Vol. 16, No. 3. pp. 374-82.

Bibtex

@article{8219eea40c8446fe912dbc8e0ad1627d,
title = "Identification and analysis of evolutionarily cohesive functional modules in protein networks",
abstract = "The increasing number of sequenced genomes makes it possible to infer the evolutionary history of functional modules, i.e., groups of proteins that contribute jointly to the same cellular function in a given species. Here we identify and analyze those prokaryotic functional modules, whose composition remains largely unchanged during evolution, and study their properties. Such {"}cohesive{"} modules have a large number of internal functional connections, encode genes that tend to be in close proximity in prokaryotic genomes, and correspond to physical complexes or complex functional systems like the flagellar apparatus. Cohesive modules are enriched in processes such as energy and amino acid metabolism, cell motility, and intracellular trafficking, or secretion. By grouping genes into modules we achieve a more precise estimate of their age and find that the young modules are often horizontally transferred between species and are enriched in functions involved in interactions with the environment, implying that they play an important role in the adaptation of species to new environments.",
author = "M{\'o}nica Campillos and {von Mering}, Christian and Jensen, {Lars Juhl} and Peer Bork",
year = "2006",
doi = "10.1101/gr.4336406",
language = "English",
volume = "16",
pages = "374--82",
journal = "Genome Research",
issn = "1088-9051",
publisher = "Cold Spring Harbor Laboratory Press",
number = "3",

}

RIS

TY - JOUR

T1 - Identification and analysis of evolutionarily cohesive functional modules in protein networks

AU - Campillos, Mónica

AU - von Mering, Christian

AU - Jensen, Lars Juhl

AU - Bork, Peer

PY - 2006

Y1 - 2006

N2 - The increasing number of sequenced genomes makes it possible to infer the evolutionary history of functional modules, i.e., groups of proteins that contribute jointly to the same cellular function in a given species. Here we identify and analyze those prokaryotic functional modules, whose composition remains largely unchanged during evolution, and study their properties. Such "cohesive" modules have a large number of internal functional connections, encode genes that tend to be in close proximity in prokaryotic genomes, and correspond to physical complexes or complex functional systems like the flagellar apparatus. Cohesive modules are enriched in processes such as energy and amino acid metabolism, cell motility, and intracellular trafficking, or secretion. By grouping genes into modules we achieve a more precise estimate of their age and find that the young modules are often horizontally transferred between species and are enriched in functions involved in interactions with the environment, implying that they play an important role in the adaptation of species to new environments.

AB - The increasing number of sequenced genomes makes it possible to infer the evolutionary history of functional modules, i.e., groups of proteins that contribute jointly to the same cellular function in a given species. Here we identify and analyze those prokaryotic functional modules, whose composition remains largely unchanged during evolution, and study their properties. Such "cohesive" modules have a large number of internal functional connections, encode genes that tend to be in close proximity in prokaryotic genomes, and correspond to physical complexes or complex functional systems like the flagellar apparatus. Cohesive modules are enriched in processes such as energy and amino acid metabolism, cell motility, and intracellular trafficking, or secretion. By grouping genes into modules we achieve a more precise estimate of their age and find that the young modules are often horizontally transferred between species and are enriched in functions involved in interactions with the environment, implying that they play an important role in the adaptation of species to new environments.

U2 - 10.1101/gr.4336406

DO - 10.1101/gr.4336406

M3 - Journal article

C2 - 16449501

VL - 16

SP - 374

EP - 382

JO - Genome Research

JF - Genome Research

SN - 1088-9051

IS - 3

ER -

ID: 40740433